Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David Goldschneider"'
Autor:
Crissy Dudgeon, Anthony Casabianca, Chris Harris, Charline Ogier, Mélanie Bellina, Stephany Fiore, Agnes Bernet, Benjamin Ducarouge, David Goldschneider, Xiaoyang Su, Jason Pitarresi, Aram Hezel, Subhajyoti De, Wade Narrow, Fady Soliman, Cory Shields, Debora Barbosa Vendramini-Costa, Orjola Prela, Lan Wang, Igor Astsaturov, Patrick Mehlen, Darren R. Carpizo
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113369- (2023)
Summary: The biology of metastatic pancreatic ductal adenocarcinoma (PDAC) is distinct from that of the primary tumor due to changes in cell plasticity governed by a distinct transcriptome. Therapeutic strategies that target this distinct biology are
Externí odkaz:
https://doaj.org/article/cc3744bb39be4610a537a760d1487cfc
Autor:
Hossein Rahimi, Kasra Arbabi Zaboli, Jose Thekkiniath, Seyed Hossein Mousavi, Behrooz Johari, Mohammad Reza Hashemi, Hamed Nosrati, David Goldschneider, Agnes Bernet, Hossein Danafar, Saeed Kaboli
Publikováno v:
Molecular biotechnology. 64(12)
The discovery of bacterial-derived Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system has revolutionized genome engineering and gene therapy due to its wide range of applications. One of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b447c797bbef5326dcf7393f8c08f63
https://pubmed.ncbi.nlm.nih.gov/35670994
https://pubmed.ncbi.nlm.nih.gov/35670994
Autor:
Robert Dante, Kate Poole, Fiona I. Schneiders, Joerg Stetefeld, Markus Meier, Trushar R. Patel, Dean Yann, Riad Abes, Denise Nikodemus, Mélodie Grandin, Natalie Krahn, David Neves, Manuel Koch, Jean-Guy Delcros, Agnès Bernet, Stéphane Depil, Patrick Mehlen, Amina Boussouar, Raphael Reuten, David Goldschneider, George L. Orriss
Publikováno v:
Cancer Cell
Cancer Cell, Elsevier, 2016, 29, pp.173-185. ⟨10.1016/j.ccell.2016.01.001⟩
Cancer Cell, 2016, 29, pp.173-185. ⟨10.1016/j.ccell.2016.01.001⟩
Cancer Cell, Elsevier, 2016, 29, pp.173-185. ⟨10.1016/j.ccell.2016.01.001⟩
Cancer Cell, 2016, 29, pp.173-185. ⟨10.1016/j.ccell.2016.01.001⟩
International audience; Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9eccfea11a96e85cba187241460d79e
Autor:
Gabriel Ichim, Géraldine Gouysse, Jean-Yves Scoazec, Marie-May Coissieux, Anne-Laure Genevois, Loraine Jarrosson-Wuilleme, Fabrice Lavial, David Goldschneider, Servane Tauszig-Delamasure, Florian Lepinasse, Zdenko Herceg, Marie-Pierre Lambert, Patrick Mehlen
Publikováno v:
Proceedings of the National Academy of Sciences. 110:3017-3022
The TrkC neurotrophin receptor belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Such a trait has been hypothesized to confer tumor-suppressor activity. Indee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9099c722c77573ea20c15e0c91f1302a
https://doi.org/10.1073/pnas.1212333110
https://doi.org/10.1073/pnas.1212333110
Autor:
Véronique Corset, Patrick Mehlen, Laurent Pays, David Goldschneider, Jérémy Lambert, Nicolas Rama
Publikováno v:
Journal of Biological Chemistry. 287:30014-30023
The multifunctional protein netrin-1 was initially discovered as the main attractive cue for commissural axon guidance by acting through its receptor DCC. Recently, we have shown that netrin-1 also interacts with the orphan transmembrane receptor amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772749e159abb6aa7dd01a0229001c57
https://doi.org/10.1074/jbc.m111.324780
https://doi.org/10.1074/jbc.m111.324780
Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo
Autor:
Benjamin Gibert, Joanna Fombonne, Chantal Diaz-Latoud, Benedicte Eckel, Blandine Deux, David Goldschneider, Philippe Clézardin, A-P Arrigo, Patrick Mehlen, V Gonin
Publikováno v:
British Journal of Cancer
Background: The small stress heat shock protein 27 (Hsp27) has recently turned as a promising target for cancer treatment. Hsp27 upregulation is associated with tumour growth and resistance to chemo- and radio-therapeutic treatments, and several ongo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ee2f3f4b3c98cdb59f5ebe3e217f9b
https://doi.org/10.1038/bjc.2012.188
https://doi.org/10.1038/bjc.2012.188
Autor:
Yan Sun, Andrea Paradisi, David Goldschneider, Patrick Mehlen, Laetitia Mazelin, Servane Tauszig-Delamasure, Amina Boussouar, Hong Wang
Publikováno v:
Molecular Cell
Molecular Cell, 2018, 72 (3), pp.413-425.e5. ⟨10.1016/j.molcel.2018.08.040⟩
Molecular Cell, Elsevier, 2018, 72 (3), pp.413-425.e5. ⟨10.1016/j.molcel.2018.08.040⟩
Molecular Cell, 2018, 72 (3), pp.413-425.e5. ⟨10.1016/j.molcel.2018.08.040⟩
Molecular Cell, Elsevier, 2018, 72 (3), pp.413-425.e5. ⟨10.1016/j.molcel.2018.08.040⟩
C-Kit has been generally considered as a receptor tyrosine kinase and a proto-oncogene, whose upregulation and mutation lead to tumor progression through its kinase activity. Clinically, drugs targeting the kinase activity of c-Kit, such as Imatinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf03086acad0619e5689e2c5d7d9991
https://doi.org/10.1016/j.molcel.2018.08.040
https://doi.org/10.1016/j.molcel.2018.08.040
Autor:
Céline Guenebeaud, Patrick Mehlen, Céline Delloye-Bourgeois, Avital Eisenberg-Lerner, David Goldschneider, Vincent Laudet, Catherine Guix, Galit Shohat, Mingjie Zhang, Agnès Bernet, Guillaume Chazot, Adi Kimchi, Marie Castets
Publikováno v:
Molecular Cell; Vol 40
Molecular Cell
Molecular Cell, 2010, 40 (6), pp.863-876. ⟨10.1016/j.molcel.2010.11.021⟩
Molecular Cell, Elsevier, 2010, 40 (6), pp.863-876. ⟨10.1016/j.molcel.2010.11.021⟩
Molecular Cell
Molecular Cell, 2010, 40 (6), pp.863-876. ⟨10.1016/j.molcel.2010.11.021⟩
Molecular Cell, Elsevier, 2010, 40 (6), pp.863-876. ⟨10.1016/j.molcel.2010.11.021⟩
International audience; The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1, and this is important for neuronal and vascular development and for limitation of cancer progression. UNC5H2 (also called UNC5B) trigge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9599e91c5f08adc0a1e7a487a99185
Autor:
Alix de La Motte, Matthieu Bauer, David Goldschneider, Emilie Horvilleur, Jean Bénard, Sétha Douc-Rasy, Xénia Mergui, David Cappellen
Publikováno v:
Nucleic Acids Research
MYCN activation, mainly by gene amplification, is one of the most frequent molecular events in neuroblastoma (NB) oncogenesis, and is associated with increased malignancy and decreased neuronal differentiation propensity. The frequency of concomitant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819866598023b0f58a8023f25a90fc61
http://europepmc.org/articles/PMC2490757
http://europepmc.org/articles/PMC2490757
Publikováno v:
Molecular and Cellular Biology. 28:4068-4079
Neogenin is a multifunctional receptor implicated in axon navigation, neuronal differentiation, morphogenesis, and cell death. Very little is known about signaling downstream of neogenin. Because we found that the neogenin intracellular domain (NeICD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e901a1a5a9d694f5460e44200f21ed3a
https://doi.org/10.1128/mcb.02114-07
https://doi.org/10.1128/mcb.02114-07