Zobrazeno 1 - 10
of 223
pro vyhledávání: '"David Givol"'
Autor:
Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15048 (2010)
BackgroundHypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the "angiogenic switch" during tumor progression. HIF-1α is often upregulated in tumors leading to more a
Externí odkaz:
https://doaj.org/article/ab2a4d89211047d4bc42ddf4cf41d1bc
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6819 (2009)
BACKGROUND:The tumor suppressor homeodomain-interacting protein kinase-2 (HIPK2) by phosphorylating serine 46 (Ser46) is a crucial regulator of p53 apoptotic function. HIPK2 is also a transcriptional co-repressor of hypoxia-inducible factor-1alpha (H
Externí odkaz:
https://doaj.org/article/6926a083ff834ae28fd738d2b7018dc1
Autor:
Gabriella D'Orazi, David Givol, Giovanni Blandino, Ada Sacchi, Carlo Leonetti, Marco Scarsella, Daniel A. Notterman, Eytan Domany, Ninette Amariglio, Gideon Rechavi, Hilah Gal, Lavinia Nardinocchi, Rosa Puca
Supplementary Table 1 from Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b653139e3669877046d8c07b799efeb
https://doi.org/10.1158/0008-5472.22370273
https://doi.org/10.1158/0008-5472.22370273
Autor:
Gabriella D'Orazi, David Givol, Giovanni Blandino, Ada Sacchi, Carlo Leonetti, Marco Scarsella, Daniel A. Notterman, Eytan Domany, Ninette Amariglio, Gideon Rechavi, Hilah Gal, Lavinia Nardinocchi, Rosa Puca
About half of cancers sustain mutations in the TP53 gene, whereas the other half maintain a wild-type p53 (wtp53) but may compromise the p53 response because of other alterations. Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305e6f48f648eada4951304a3eef8cb2
https://doi.org/10.1158/0008-5472.c.6496337.v1
https://doi.org/10.1158/0008-5472.c.6496337.v1
Autor:
Lea Schechtman, Ora Freyhan, Calanit Raanan, Letizia Schreiber, David Givol, Abraham Amsterdam
Publikováno v:
Acta Histochemica. 115:330-338
LGR5 and Nanog were recently characterized as stem cell markers in various embryonic, adult and cancer stem cells. However, there are no data on their precise localization in the normal adult ovary, which may be important for the initial steps of dev
Autor:
Ehud Melzer, Calanit Raanan, David Givol, Ora Freyhan, Letizia Schreiber, Yakov Fabrikant, Abraham Amsterdam
Publikováno v:
Acta Histochemica. 115:320-329
One paradigm of cancer development claims that cancer emerges at the niche of tissue stem cells and these cells continue to proliferate in the tumor as cancer stem cells. LGR5, a membrane receptor, was recently found to be a marker of normal colon st
Publikováno v:
Biochemical and Biophysical Research Communications. 433:157-162
Pancreas cancer, is the fourth leading cause of cancer death but its cell of origin is controversial. We compared the localization of stem cells in normal and cancerous pancreas using antibodies to the stem cell markers Nanog and LGR5. Here we show,
Autor:
Eleonora Lapi, Hilah Gal, David Givol, Eytan Domany, Silvia Di Agostino, Pier Paolo Pandolfi, Xin Lu, Giovanni Blandino, Sabrina Strano, Sara Donzelli, Gideon Rechavi
p73 has been identified as a structural and functional homolog of the tumor suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance p73-dependent apoptosis in response to DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa2b5d15b81a72db14b7eea6e565815
https://ora.ox.ac.uk/objects/uuid:6c87c0b1-03d0-4e17-a66f-22ea4ab64fb9
https://ora.ox.ac.uk/objects/uuid:6c87c0b1-03d0-4e17-a66f-22ea4ab64fb9
Autor:
David Givol, Valentina Folgiero, Cristina Nodale, Aurora Aiello, Alessia Garufi, Rita Falcioni, Gideon Rechavi, Jasmine Jacob-Hirsch, Gabriella D'Orazi, Michal Sheffer
Publikováno v:
Cancer Biology & Therapy. 13:198-205
Vimentin, a mesenchymal marker, is frequently overexpressed in epithelial carcinomas undergoing epithelial to mesenchymal transition (EMT), a condition correlated with invasiveness and poor prognosis. Therefore, vimentin is a potential molecular targ
Autor:
Michal Sheffer, Gideon Rechavi, Eytan Domany, Gabriella D'Orazi, David Givol, Amos J. Simon, Jasmine Jacob-Hirsch
Publikováno v:
Oncotarget
Michal Sheffer 1 , Amos J. Simon 2 , Jasmine Jacob-Hirsch 2 , Gideon Rechavi 2 , Eytan Domany 1 , David Givol 3 and Gabriella D’Orazi 4,5 1 Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel 2 Department