Zobrazeno 1 - 10
of 183
pro vyhledávání: '"David Gius"'
Autor:
Yueming Zhu, Xianghui Zou, Angela E. Dean, Joseph O’ Brien, Yucheng Gao, Elizabeth L. Tran, Seong-Hoon Park, Guoxiang Liu, Matthew B. Kieffer, Haiyan Jiang, Melissa E. Stauffer, Robert Hart, Songhua Quan, Karla J. F. Satchell, Nobuo Horikoshi, Marcelo Bonini, David Gius
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as
Externí odkaz:
https://doaj.org/article/024c2a17f581441ca1d27fe75c08a597
Autor:
Meredith M. Ogle, Rolando Trevino, Joseph Schell, Mahboubeh Varmazyad, Nobuo Horikoshi, David Gius
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 635 (2022)
The loss and/or dysregulation of several cellular and mitochondrial antioxidants’ expression or enzymatic activity, which leads to the aberrant physiological function of these proteins, has been shown to result in oxidative damage to cellular macro
Externí odkaz:
https://doaj.org/article/6836ea2529e64b87bbdc915a19a4d5e8
Autor:
Hui Zhang, PamelaSara E. Head, Waaqo Daddacha, Seong-Hoon Park, Xingzhe Li, Yunfeng Pan, Matthew Z. Madden, Duc M. Duong, Maohua Xie, Bing Yu, Matthew D. Warren, Elaine A. Liu, Vishal R. Dhere, Chunyang Li, Ivan Pradilla, Mylin A. Torres, Ya Wang, William S. Dynan, Paul W. Doetsch, Xingming Deng, Nicholas T. Seyfried, David Gius, David S. Yu
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1435-1447 (2016)
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear. We found that deacetylation of ATR-interactin
Externí odkaz:
https://doaj.org/article/f2ddce6c8fc04efcab79c55c54406ab7
Autor:
Louise Lantier, Ashley S Williams, Curtis C Hughey, Deanna P Bracy, Freyja D James, Muhammad A Ansari, David Gius, David H Wasserman
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208634 (2018)
The NAD+-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the
Externí odkaz:
https://doaj.org/article/6ef0b042180f4c73a161d221e72acb4c
Autor:
Uma Shankavaram, Stephanie M.J. Fliedner, Abdel G. Elkahloun, Jenifer J. Barb, Peter J. Munson, Thanh T. Huynh, Joey C. Matro, Hana Turkova, W. Marston Linehan, Henri J. Timmers, Arthur S. Tischler, James F. Powers, Ronald de Krijger, Bora E. Baysal, Martina Takacova, Silvia Pastorekova, David Gius, Hendrik Lehnert, Kevin Camphausen, Karel Pacak
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 435-447 (2013)
Pheochromocytomas (PHEOs) and paragangliomas (PGLs) related to mutations in the mitochondrial succinate dehydrogenase (SDH) subunits A, B, C, and D, SDH complex assembly factor 2, and the von Hippel-Lindau (VHL) genes share a pseudohypoxic expression
Externí odkaz:
https://doaj.org/article/bc1f6e8c0b474f62812bf7827d1c2d85
Autor:
Nicole L Simone, Benjamin P Soule, David Ly, Anthony D Saleh, Jason E Savage, William Degraff, John Cook, Curtis C Harris, David Gius, James B Mitchell
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6377 (2009)
BACKGROUND:MicroRNAs (miRNAs) are small, highly conserved, non-coding RNA that alter protein expression and regulate multiple intracellular processes, including those involved in the response to cellular stress. Alterations in miRNA expression may oc
Externí odkaz:
https://doaj.org/article/9c1bacd4cad947c488e5e02b40d29a7f
Publikováno v:
Physiology. 38
Obesity is characterized by an increase in adipose mass and is the leading risk factor for type 2 diabetes. Recent research suggests that activation of brown or beige fat and white adipose tissue browning represent a new therapeutic strategy for meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fec2044b10a4ddb948cf8c86d1db81b2
https://doi.org/10.1152/physiol.2023.38.s1.5734213
https://doi.org/10.1152/physiol.2023.38.s1.5734213
Autor:
David Gius, Haiyan Jiang, Joseph O'Brien, Guoxiang Liu, Seong-Hoon Park, Yueming Zhu, Xianghui Zou
Figure S1. Starvation decreased mitochondrial acetylation in MCF7 cells; Figure S2. The image of all harvested tumors from immunodeficient mice injected with MCF-shIDH2-IDH2WT, MCF7-shIDH2-IDH2K413R and MCF7-shIDH2-IDH2K413Q cells were presented; Fig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e72ae27204b8078277163efde03a38
https://doi.org/10.1158/0008-5472.22414868.v1
https://doi.org/10.1158/0008-5472.22414868.v1
Autor:
David Gius, Haiyan Jiang, Joseph O'Brien, Guoxiang Liu, Seong-Hoon Park, Yueming Zhu, Xianghui Zou
The isocitrate dehydrogenase IDH2 produces α-ketoglutarate by oxidizing isocitrate, linking glucose metabolism to oxidative phosphorylation. In this study, we report that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62ca5d2f52f7394986043a4124d41595
https://doi.org/10.1158/0008-5472.c.6509099.v1
https://doi.org/10.1158/0008-5472.c.6509099.v1