Zobrazeno 1 - 10
of 598
pro vyhledávání: '"David Ginsburg"'
Autor:
Vi T. Tang, David Ginsburg
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Most proteins destined for the extracellular space or various intracellular compartments must traverse the intracellular secretory pathway. The first step is the recruitment and transport of cargoes from the endoplasmic reticulum (ER) lumen to the Go
Externí odkaz:
https://doaj.org/article/ee1bd5cbd9e740bca717094050de240e
Autor:
Elizabeth J. Adams, Rami Khoriaty, Anna Kiseleva, Audrey C. A. Cleuren, Kärt Tomberg, Martijn A. van der Ent, Peter Gergics, Vi T. Tang, Guojing Zhu, Mark J. Hoenerhoff, K. Sue O’Shea, Thomas L. Saunders, David Ginsburg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The COPII component SEC24 mediates the recruitment of transmembrane cargos or cargo adaptors into newly forming COPII vesicles on the ER membrane. Mammalian genomes encode four Sec24 paralogs (Sec24a-d), with two subfamilies based on sequenc
Externí odkaz:
https://doaj.org/article/4bcbdf66d6ff48cf95ab2150fccf4a2b
Autor:
Zachary M. Huttinger, Laura M. Haynes, Andrew Yee, Colin A. Kretz, Matthew L. Holding, David R. Siemieniak, Daniel A. Lawrence, David Ginsburg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Mis
Externí odkaz:
https://doaj.org/article/f47950a71a2243e4bed673bbf54e9f40
Autor:
Vi T Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T Emmer, Xiao-Wei Chen, David Ginsburg
Publikováno v:
eLife, Vol 11 (2022)
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor t
Externí odkaz:
https://doaj.org/article/a6d70a225b594945be13e85a8f5d5bed
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100248- (2022)
The low-density lipoprotein receptor (LDLR) mediates the hepatic uptake of circulating low-density lipoproteins (LDLs), a process that modulates the development of atherosclerotic cardiovascular disease. We recently identified RAB10, encoding a small
Externí odkaz:
https://doaj.org/article/c627a1b69d3547199164452f4b476cf9
Autor:
Mayara Garcia de Mattos Barbosa, Hui Liu, Daniel Huynh, Greg Shelley, Evan T. Keller, Brian T. Emmer, Emily Sherman, David Ginsburg, Andrew A. Kennedy, Andrew W. Tai, Christiane Wobus, Carmen Mirabeli, Thomas M. Lanigan, Milagros Samaniego, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Abs that neutralize SARS-CoV-2 are thought to provide the most immediate and effective treatment for those severely afflicted by this virus. Because coronavirus potentially diversifies by mutation, broadly neutralizing Abs are especially sought. Here
Externí odkaz:
https://doaj.org/article/198aea9cddb24432ade981042f42b068
Autor:
Brian T Emmer, Paul J Lascuna, Vi T Tang, Emilee N Kotnik, Thomas L Saunders, Rami Khoriaty, David Ginsburg
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227450 (2020)
Newly synthesized proteins co-translationally inserted into the endoplasmic reticulum (ER) lumen may be recruited into anterograde transport vesicles by their association with specific cargo receptors. We recently identified a role for the cargo rece
Externí odkaz:
https://doaj.org/article/727d58a836d841bb96970c37a76b1129
Autor:
S. Julia Wu, Yashar S. Niknafs, Stephanie H. Kim, Katherine Oravecz-Wilson, Cynthia Zajac, Tomomi Toubai, Yaping Sun, Jayendra Prasad, Daniel Peltier, Hideaki Fujiwara, Israel Hedig, Nathan D. Mathewson, Rami Khoriaty, David Ginsburg, Pavan Reddy
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2645-2656 (2017)
Cross-presentation initiates immune responses against tumors and viral infections by presenting extracellular antigen on MHC I to activate CD8+ T cell-mediated cytotoxicity. In vitro studies in dendritic cells (DCs) established SNARE protein SEC22B a
Externí odkaz:
https://doaj.org/article/09cc1a6c139c4caab73f2931786aa756
Autor:
Ursula Waack, Mark Warnock, Andrew Yee, Zachary Huttinger, Sara Smith, Ayush Kumar, Alban Deroux, David Ginsburg, Harry L. T. Mobley, Daniel A. Lawrence, Maria Sandkvist
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Antibiotic-resistant Acinetobacter baumannii is increasingly recognized as a cause of difficult-to-treat nosocomial infections, including pneumonia, wound infections, and bacteremia. Previous studies have demonstrated that the metalloproteas
Externí odkaz:
https://doaj.org/article/d973548e5bd446dbbe654031c2645100
Autor:
Kärt Tomberg, Randal J Westrick, Emilee N Kotnik, Audrey C Cleuren, David R Siemieniak, Guojing Zhu, Thomas L Saunders, David Ginsburg
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007658 (2018)
Although the Factor V Leiden (FVL) gene variant is the most prevalent genetic risk factor for venous thrombosis, only 10% of FVL carriers will experience such an event in their lifetime. To identify potential FVL modifier genes contributing to this i
Externí odkaz:
https://doaj.org/article/7f6dd58dc42c40b3b11b6c154e36f9c2