Zobrazeno 1 - 2
of 2
pro vyhledávání: '"David Gerard Bourke"'
Autor:
Jonathan Coates, Eric Dale Jones, Susan Cox, Nick Vandegraaff, Paula J De Bruyn, David Rhodes, David Gerard Bourke, Alan D. Robertson, Ian Travers Crosby
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:6442-6450
The synthesis of a new series of conocurvone analogues is presented that explores the importance of the pyran rings of conocurvone, their degree of unsaturation as well as the role of alkoxy functionalities as pyran ring replacements, for the inhibit
Autor:
Laura Andrau, Margarita Kurek, R Marcel Kling, Andrew Craig Donohue, Harrison Sikanyika, David M. Shackleford, Andrew F. Wilks, John Thomas Feutrill, Tracy L. Nero, Emmanuelle Fantino, Herbert R. Treutlein, Michelle Farrugia, Ian D Phillips, Michelle Leanne Styles, David Gerard Bourke, Jun Zeng, Thao Kim Nu Nguyen, Christopher J. Burns, James T. Palmer, Max Joffe, Xianyong Bu, Stephen Su, Susan A. Charman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5887-5892
A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzam