Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David Gennert"'
Autor:
Robert C. Jones, Surya Nagaraja, Ansuman T. Satpathy, Michelle Monje, Zinaida Good, Elena Sotillo, Howard Y. Chang, Peng Xu, Hima Anbunathan, Evan W. Weber, Crystal L. Mackall, Rachel C. Lynn, Charles F. A. de Bourcy, David Gennert, John Lattin, Jeffrey M. Granja, Robbie G. Majzner, Victor Tieu, Stephen R. Quake
Publikováno v:
Nature
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1-3, but dysfunction due to T cell exhaustion is an important barrier to progress4-6. To investigate the biology of exhaustion in human T cel
Autor:
Ansuman T. Satpathy, Tieu, Elena Sotillo, DeBourcy C, Robbie G. Majzner, Crystal L. Mackall, Rachel C. Lynn, David Gennert, Robert C. Jones, Howard Y. Chang, Peng Xu, Zinaida Good, Jeffrey M. Granja, Hima Anbunathan, Evan W. Weber
SUMMARYCAR T cells mediate antitumor effects in a small subset of cancer patients, but dysfunction due to T cell exhaustion is an important barrier to progress. To investigate the biology of exhaustion in human T cells expressing CAR receptors, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab659eb54cd5c6335ee8d4dfe8197073
https://doi.org/10.1101/653725
https://doi.org/10.1101/653725
Autor:
Paul A. Khavari, David Gennert, Caitlin M. Roake, Maninjay K. Atianand, Ryan A. Flynn, M. Ryan Corces, Jimmy K. Guo, Maxwell R. Mumbach, Bryan H. Louie, Steven E. Artandi, Adam J. Rubin, Yanyan Qi, Shadi Shams, Ansuman T. Satpathy, Howard Y. Chang, Katherine A. Fitzgerald, Jeffrey M. Granja, Zhaozhao Jiang, William J. Greenleaf
Publikováno v:
Protocol Exchange.
Autor:
Jimmy K. Guo, Ansuman T. Satpathy, Yanyan Qi, Paul A. Khavari, M. Ryan Corces, Maninjay K. Atianand, Ryan A. Flynn, Bryan H. Louie, William J. Greenleaf, Howard Y. Chang, Steven E. Artandi, Jeffrey M. Granja, Katherine A. Fitzgerald, Adam J. Rubin, Zhaozhao Jiang, Caitlin M. Roake, Maxwell R. Mumbach, David Gennert, Shadi Shams
Publikováno v:
Nature methods. 16(6)
Modular domains of long non-coding RNAs can serve as scaffolds to bring distant regions of the linear genome into spatial proximity. Here, we present HiChIRP, a method leveraging bio-orthogonal chemistry and optimized chromosome conformation capture
For the past several decades, due to technical limitations, the field of transcriptomics has focused on population‐level measurements that can mask significant differences between individual cells. With the advent of single‐cell RNA‐Seq, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b0213dc533bf566ea6d08877a47d2cd
https://doi.org/10.17504/protocols.io.pbgdijw
https://doi.org/10.17504/protocols.io.pbgdijw
For the past several decades, due to technical limitations, the field of transcriptomics has focused on population‐level measurements that can mask significant differences between individual cells. With the advent of single‐cell RNA‐Seq, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dc36f056cf2015ff9ef5029b1fb6f
https://doi.org/10.17504/protocols.io.pbhdij6
https://doi.org/10.17504/protocols.io.pbhdij6
This is aSingle-cell RNA-Seq expression analysisSupport Protocol forPreparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b338449171e1de763581bd5c6ae5bf74
https://doi.org/10.17504/protocols.io.pbidike
https://doi.org/10.17504/protocols.io.pbidike
Publikováno v:
Nature biotechnology
Spatial localization is a key determinant of cellular fate and behavior, but methods for spatially resolved, transcriptome-wide gene expression profiling across complex tissues are lacking. RNA staining methods assay only a small number of transcript
Autor:
Patrick Cahan, Aviv Regev, James J. Collins, Thomas C. Ferrante, George Q. Daley, Hu Li, Roshan M. Kumar, David Gennert, Keith Pardee, Alex K. Shalek, Rahul Satija, AJay DaleyKeyser, Jin Zhang, John J. Trombetta
Publikováno v:
Nature
SUMMARY Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct substates, but the regulatory circuits specifying these states and enabling transitions between them are not well understood. We set out to characterize tra
Autor:
Nir Yosef, Aviv Regev, Andrew May, John J. Trombetta, Ruihua Ding, Hongkun Park, Joe Shuga, Brian Fowler, Xiaohui Wang, Raktima Raychowdhury, David Gennert, Diana Lu, Jellert T. Gaublomme, Rahul Satija, Schraga Schwartz, Peilin Chen, Nir Friedman, Alex K. Shalek, Jing Wang, Rona S. Gertner, Nir Hacohen, Suzanne Weaver
Publikováno v:
Nature
High-throughput single-cell transcriptomics offers an unbiased approach for understanding the extent, basis and function of gene expression variation between seemingly identical cells. Here we sequence single-cell RNA-seq libraries prepared from over