Zobrazeno 1 - 10
of 150
pro vyhledávání: '"David Gani"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1623-1626
Substrate analogues based on the parent compounds paraoxon and phenyl acetate were tested on human serum paraoxonase (PON1) to explore the active site of the enzyme. Replacement of the nitro group of paraoxon with an amine or hydrogen, as well as ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce1518d3660bae186ce1601239cf4a9
https://doi.org/10.1016/s0960-894x(03)00290-7
https://doi.org/10.1016/s0960-894x(03)00290-7
Autor:
Lorraine E. Hughes, Vanessa M. Cowton, Garry A. Luke, Michelle L. L. Donnelly, Martin D. Ryan, Amit P. Mehrotra, Xuejun Li, Edwin ten Dam, David Gani
In the case of the aphtho- and cardioviruses, the primary cleavage in the region of the polyprotein was known to be different, occurring at the C terminus of 2A. Precursor forms spanning the 2A/2B junction are not observed in aphtho- or cardiovirus p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f76a41fdc37307062b4f07641a37156f
https://doi.org/10.1128/9781555817916.ch18
https://doi.org/10.1128/9781555817916.ch18
Autor:
David Gani, Trevor J. Rutherford, Chinh Q. Vu, Klaus D. Schnackerz, John Wilkie, Myron K. Jacobson
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:1485-1495
A possible pH-dependent conformational switch was investigated for cyclic ADP-ribose. NMR signals for the exchangeable protons were observed in H2O at low temperature, but there was no direct evidence for the protonation of N-3 at neutral pH that has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3673218ef5f399c1f6ecf7c6249fd533
https://doi.org/10.1081/ncn-100105243
https://doi.org/10.1081/ncn-100105243
Autor:
Jonathan Sanvoisin, David Gani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:471-474
The catalytic subunit of the Ser/Thr protein phosphatase 1 (PP1 cat ) hydrolyses N -acetyl Arg-Arg-Ala-phosphoThr-Val-Ala ( K M =3.7 mM) in a reaction that is inhibited competitively by inorganic phosphate (P i , K i =1.6 mM) but unaffected by the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320ad6570e43a6b481b0987071f5876a
https://doi.org/10.1016/s0960-894x(00)00694-6
https://doi.org/10.1016/s0960-894x(00)00694-6
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1673-1695
Nodularin and microcystins are complex natural cyclic isopeptidic hepatotoxins that serve as subnanomolar inhibitors of the eukaryotic serine–threonine protein phosphatases PP1 and PP2A, enzymes that are intimately involved in controlling cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::095c40d7bc0895eb315e8f5eb0d4e717
https://doi.org/10.1039/b100401h
https://doi.org/10.1039/b100401h
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1709-1715
A new and sensitive activity assay for the Ser-Thr protein phosphatases PP1 and PP2A based upon the hydrolysis of the synthetic radiolabelled phosphopeptide substrate N-acetyl-Arg-Arg-Ala-Thr(P)-Val-Ala, is described. The protocol is also applicable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680bfd44e12af5f8c254e117492b36e0
https://doi.org/10.1039/b100403o
https://doi.org/10.1039/b100403o
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1696-1708
In order to probe the effect upon macrocycle conformation and PP1cat enzyme inhibition of structural changes to nodularin, specific replacements for the Adda residue were introduced. Two new analogues, cyclo[-(3S,E)-3-phenylethenyl-3-aminopropanoyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5161fe1163c22ed84b36582e9c93cfdc
https://doi.org/10.1039/b100402f
https://doi.org/10.1039/b100402f
Publikováno v:
ChemBioChem. 1:262-271
Inositol monophosphatase plays a pivotal role in the biosynthesis of secondary messengers and is believed to be a target for lithium therapy. It is established how a lithium ion works in inhibiting the enzyme but details of the mechanism for the dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::292fc37ea019da975f6877c892304b00
https://doi.org/10.1002/1439-7633(20001117)1:4<262::aid-cbic262>3.0.co
https://doi.org/10.1002/1439-7633(20001117)1:4<262::aid-cbic262>3.0.co
Publikováno v:
Tetrahedron Letters. 41:4487-4491
The preparation and properties of Nafion resin sulfonamide systems derived from methyl glycinate and from 3-hydroxyethylaniline are described. Nafion derivatisation reactions were slow and maximum achievable functionalisations were 50% of the ion exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e94d6ff963374c4e08e2e35aa9c6959f
https://doi.org/10.1016/s0040-4039(00)00646-8
https://doi.org/10.1016/s0040-4039(00)00646-8
Publikováno v:
Tetrahedron Letters. 41:4493-4497
Monomers α,β,β-trifluorostyrene and 4-methyl-α,β,β-trifluorostyrene were prepared and were copolymerised under free-radical emulsion conditions to give highly stable, well defined lipophilic polymer resins. Benzylic halogenation of the polymer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726816f988cd001eee0e99e6a2306284
https://doi.org/10.1016/s0040-4039(00)00647-x
https://doi.org/10.1016/s0040-4039(00)00647-x