Zobrazeno 1 - 10
of 430
pro vyhledávání: '"David G. le Couteur"'
Autor:
Glen P. Lockwood, Nicholas J. Hunt, Maaike Kockx, Sun Woo Sophie Kang, David G. Le Couteur, Victoria C. Cogger
Publikováno v:
Livers, Vol 4, Iss 2, Pp 253-267 (2024)
The clearance of peripheral beta amyloid (Aβ) is a potential target for the treatment of Alzheimer’s disease (AD). The liver has been implicated in the elimination of Aβ from the peripheral circulation. Here, the single-pass uptake of Aβ40 in pe
Externí odkaz:
https://doaj.org/article/806bbeb6b8204766ad27b1ec7abc3583
Autor:
Samantha M. Solon-Biet, Ximonie Clark, Kim Bell-Anderson, Patricia M. Rusu, Ruth Perks, Therese Freire, Tamara Pulpitel, Alistair M. Senior, Andrew J. Hoy, Okka Aung, David G. Le Couteur, David Raubenheimer, Adam J. Rose, Arthur D. Conigrave, Stephen J. Simpson
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113536- (2023)
Summary: Fibroblast growth factor 21 (FGF21), an endocrine signal robustly increased by protein restriction independently of an animal’s energy status, exerts profound effects on feeding behavior and metabolism. Here, we demonstrate that considerin
Externí odkaz:
https://doaj.org/article/67b2b68aaa1d44e198ce08c2781e6b02
Autor:
Eric P. F. Chow, Benjumin Hsu, Louise M. Waite, Fiona M. Blyth, David J. Handelsman, David G. Le Couteur, Vasi Naganathan, Fiona F. Stanaway
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Routinely collected health administrative data can be used to estimate the prevalence or incidence of dementia at a population level but can be inaccurate. This study aimed to examine the accuracy of hospital and death data for di
Externí odkaz:
https://doaj.org/article/349462fb8b2f444a8304ac92965e0b95
Autor:
Alistair M. Senior, Véronique Legault, Francis B. Lavoie, Nancy Presse, Pierrette Gaudreau, Valérie Turcot, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson, Alan A. Cohen
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Little is known about how normal variation in dietary patterns in humans affects the ageing process. To date, most analyses of the problem have used a unidimensional paradigm, being concerned with the effects of a single nutrient
Externí odkaz:
https://doaj.org/article/03a2395839b541ea9cc6137260cf87e6
Autor:
Samantha M. Solon-Biet, Lucy Griffiths, Sophie Fosh, David G. Le Couteur, Stephen J. Simpson, Alistair M. Senior
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background The role of dietary branched chain amino acids (BCAAs) and their effect on metabolic health is complex. How dietary BCAA levels and their interaction with background nutrition affect health is unclear. Here, we used meta-analysis
Externí odkaz:
https://doaj.org/article/9aba48b7982f47f2a756a6c4bd886f16
Autor:
Sachiko Takehara, F. A. Clive Wright, Vasi Naganathan, Vasant Hirani, Fiona M. Blyth, David G. Le Couteur, Louise M. Waite, Markus J. Seibel, David J. Handelsman, Robert G. Cumming
Publikováno v:
International Dental Journal, Vol 71, Iss 3, Pp 224-232 (2021)
Background: Assessing perceived needs for dental treatment is important in understanding and predicting people's health behaviours. The purpose of this study is to examine older men's perceptions regarding dental treatment needs, and to investigate t
Externí odkaz:
https://doaj.org/article/c2f4c82867934106b02baf0381bff2e7
Autor:
Sachiko Takehara, Vasant Hirani, F. A. Clive Wright, Vasi Naganathan, Fiona M. Blyth, David G. Le Couteur, Louise M. Waite, Markus J. Seibel, David J. Handelsman, Robert G. Cumming
Publikováno v:
BMC Geriatrics, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Unintended weight loss and the reduction in appetite are common phenomenon among older people. Reduced appetite has been linked to medication related reductions in saliva production, reduced taste ability and poor oral health. Poo
Externí odkaz:
https://doaj.org/article/fadec005c44c4cd1b97dad7e19f4c4da
Autor:
David Raubenheimer, Alistair M. Senior, Christen Mirth, Zhenwei Cui, Rong Hou, David G. Le Couteur, Samantha M. Solon-Biet, Pierre Léopold, Stephen J. Simpson
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104315- (2022)
Summary: Animals require specific blends of nutrients that vary across the life course and with circumstances, e.g., health and activity levels. Underpinning and complicating these requirements is that individual traits may be optimized on different
Externí odkaz:
https://doaj.org/article/f5fbf4cca80842698fc139a0e17d58a3
Autor:
Saman Khalatbari-Soltani, Fiona Stanaway, Erin Cvejic, Fiona M. Blyth, Vasi Naganathan, David J. Handelsman, David G. Le Couteur, Markus J. Seibel, Louise M. Waite, Robert G. Cumming
Publikováno v:
International Journal for Equity in Health, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract Background Among older people, the extent to which psychosocial factors explain socioeconomic inequalities in mortality is debated. We aimed to investigate the potential mediating effect of psychosocial factors on socioeconomic inequalities
Externí odkaz:
https://doaj.org/article/12053ad1f47047be9b178632eee20b17
Autor:
Saman Khalatbari-Soltani, Fiona M. Blyth, Vasi Naganathan, David J. Handelsman, David G. Le Couteur, Markus J. Seibel, Louise M. Waite, Erin Cvejic, Robert G. Cumming
Publikováno v:
BMC Geriatrics, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Conflicting evidence exists regarding the association of socioeconomic status (SES) with mortality among older people and little is known about the mechanisms underlying this association. We investigated the association of SES wit
Externí odkaz:
https://doaj.org/article/68ac43ed1b3c44e1a42345d08094e4e8