Výsledky vyhledávání - "David G. Witte"

Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats

Autor: Uwe Müller, Teresa Ellis, Wayne R. Buck, Bradley A. Hooker, Ann Tovcimak, Nathan R. Rustay, Steven C. Cassar, Dancia Scharf, Jeffrey F. Waring, Kevin K.W. Wang, Jinhe Li, Andreas Jeromin, David G. Witte

Publikováno v: Journal of Neuroscience Methods. 192:249-253

Cerebrospinal fluid (CSF) is commonly used for assessing biomarkers of drug efficacy or disease progression in the central nervous system. Studies of CSF from pre-clinical species can characterize biomarkers for use in clinical trials. However, obtai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20be3623bbb2039516b3b170c718bbe
https://doi.org/10.1016/j.jneumeth.2010.07.042

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H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Autor: Arthur A. Hancock, Jill M. Wetter, Kennan C. Marsh, Prisca Honore, Gin C. Hsieh, Anita K. Salyers, Prasant Chandran, Timothy A. Esbenshade, Marlon D. Cowart, Joe Mikusa, Jorge D. Brioni, Erica J. Wensink, Madhavi Pai, Thomas R. Miller, Scott J. Baker, Chang Z. Zhu, David G. Witte

Publikováno v: Pharmacology Biochemistry and Behavior. 95:41-50

The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H(4)R in pain transmission, the effects of JNJ7777120, a potent and selective H(4) antagonist, were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3217e8b864839ddd3ab2c66a0d548d8d
https://doi.org/10.1016/j.pbb.2009.12.004

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In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties

Publikováno v: British Journal of Pharmacology. 157:44-54

Background and purpose: The histamine H4 receptor is widely expressed in cells of immune origin and has been shown to play a role in a variety of inflammatory processes mediated by histamine. In this report, we describe the in vitro and in vivo anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b03928338c4004241fbc453c91f11f2
https://doi.org/10.1111/j.1476-5381.2009.00236.x

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An 80-Amino Acid Deletion in the Third Intracellular Loop of a Naturally Occurring Human Histamine H3 Isoform Confers Pharmacological Differences and Constitutive Activity

Autor: Peter van Meer, Marlon D. Cowart, Marina Strakhova, David G. Witte, John L. Baranowski, Rob Leurs, Arthur A. Hancock, Brian R. Estvander, Gerold Bongers, Thomas R. Miller, Kathleen M. Krueger, Remko A. Bakker, Timothy A. Esbenshade

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics, 323(3), 888-98. American Society for Pharmacology and Experimental Therapeutics
Bongers, G M, Krueger, K M, Miller, T R, Baranowski, J L, Estvander, B R, Witte, D G, Strakhova, M I, van der Meer, P, Bakker, R A, Cowart, M D, Hancock, A A, Esbenshade, T A & Leurs, R 2007, ' An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity ', The Journal of Pharmacology and Experimental Therapeutics, vol. 323, no. 3, pp. 888-98 . https://doi.org/10.1124/jpet.107.127639

In this article, we pharmacologically characterized two naturally occurring human histamine H3 receptor (hH3R) isoforms, hH3R(445) and hH3R(365). These abundantly expressed splice variants differ by a deletion of 80 amino acids in the intracellular l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062d4248884dcb2bada0b5a82bba63e3
https://doi.org/10.1124/jpet.107.127639

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Detection of multiple H3 receptor affinity states utilizing [3 H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand

Autor: Arthur A. Hancock, Bruce W. Surber, Rahul Sharma, David G. Witte, Timothy A. Esbenshade, Tracy L. Carr, Betty B. Yao, Kathleen M. Krueger, Ramin Faghih, Thomas R. Miller, Steven Cassar

Publikováno v: British Journal of Pharmacology. 148:657-670

A-349821 is a selective histamine H3 receptor antagonist/inverse agonist. Herein, binding of the novel non-imidazole H3 receptor radioligand [3H]A-349821 to membranes expressing native or recombinant H3 receptors from rat or human sources was charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3722fc65f7795de1c444ddfd44a24b85
https://doi.org/10.1038/sj.bjp.0706752

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G Protein-Dependent Pharmacology of Histamine H3 Receptor Ligands: Evidence for Heterogeneous Active State Receptor Conformations

Autor: S A Buckner, Lynne Ireland-Denny, Thomas R. Miller, Ivan Milicic, Kathleen M. Krueger, Timothy A. Esbenshade, John L. Baranowski, Arthur A. Hancock, David G. Witte

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 314:271-281

Previously reported pharmacological studies using the imidazole-containing histamine H3 receptor ligands GT-2331 (Cipralisant) and proxyfan resulted in a range of classifications (antagonist, agonist, and protean) for these compounds. We examined the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315e59d2faa8ccd10e4f798a104a01e7
https://doi.org/10.1124/jpet.104.078865

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Structure–activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists

Autor: Betty B. Yao, Ramin Faghih, Thomas R. Miller, Henry Zhang, Youssef L. Bennani, Timothy A. Esbenshade, David G. Witte, Gregory A. Gfesser, Gerard B. Fox, Jia Bao Pan, Arthur A. Hancock, Chae-Hee Kang, Jürgen Dinges, Kathy M. Krueger

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:673-676

Further SAR studies on novel histamine H(3) receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dips

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed226c898efdb95d448246274d9c2d1
https://doi.org/10.1016/j.bmcl.2003.11.038

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Regulation of the Release of Interleukin-6 from Human Astrocytoma Cells

Autor: David G. Witte, Chi-Ming Lee, Evelyn D. Cadman

Publikováno v: Journal of Neurochemistry. 63:980-987

Recent evidence suggests that the level of interleukin-6 (IL-6) is elevated in Alzheimer's disease (AD) brains. IL-6 is produced by reactive glial cells and could potentially affect neuronal survival. Understanding the biochemical mechanism that regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a6950e5b0583187f35887755c7144c
https://doi.org/10.1046/j.1471-4159.1994.63030980.x

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Cerebrospinal fluid cytokine dynamics differ between Alzheimer disease patients and elderly controls

Autor: Robert A. Lenz, Teresa Ellis, Viswanath Devanarayan, David G. Witte, Jeffrey F. Waring, Daniel A. Llano, Jinhe Li

Publikováno v: Alzheimer disease and associated disorders. 26(4)

The time courses of levels of multiple plasma and cerebrospinal fluid (CSF) cytokines in patients with Alzheimer disease (AD) and in age-matched control subjects were compared. Interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, granulocyte-macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7c37e6c662efd5c6270a2e5d5199b0
https://pubmed.ncbi.nlm.nih.gov/22089638

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Double bond isosteres of the peptide bond: Synthesis and biological activity of cholecystokinin (CCK) C-terminal hexapeptide analogs

Autor: Sharon L. Kuyper, Alex M. Nadzan, Chun Wel Lin, Michael D. Tufano, Mike Stashko, Thomas R. Miller, Mark W. Holladay, Hana Kopecka, David G. Witte, Y.‐K. Shue, George M. Carrera

Publikováno v: Bioorganic & Medicinal Chemistry. 1:161-171

New and existing methodologies were used to prepare a series of modified CCK analogs in which each amide bond was replaced by a trans-alkene unit. The data indicate that every amide linkage at C-terminal tetrapeptide (CCK-4) region is crucial for bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed43732409febe53663b805ae77254d
https://doi.org/10.1016/s0968-0896(00)82117-3

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