Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David G. Wernick"'
Autor:
Elad Herz, Niv Antonovsky, Yinon Bar-On, Dan Davidi, Shmuel Gleizer, Noam Prywes, Lianet Noda-Garcia, Keren Lyn Frisch, Yehudit Zohar, David G. Wernick, Alon Savidor, Uri Barenholz, Ron Milo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
An E. coli strain able to use CO2 fixation for sugar synthesis was previously generated by experimental evolution of an engineered strain. Here, Herz et al. show that specific mutations in five genes, encoding carbon metabolism enzymes or key regulat
Externí odkaz:
https://doaj.org/article/690248970691410cad98d1f38c3b74f9
Autor:
Kevin K. Yang, Alina Batzilla, David P Weiner, Zachary Wu, Alycia Lee, David G. Wernick, Michael Liszka, Frances H. Arnold
Publikováno v:
ACS synthetic biology. 9(8)
Short (15–30 residue) chains of amino acids at the amino termini of expressed proteins known as signal peptides (SPs) specify secretion in living cells. We trained an attention-based neural network, the Transformer model, on data from all available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1dbeebb4601670074fd808221acce07
https://pubmed.ncbi.nlm.nih.gov/32649182
https://pubmed.ncbi.nlm.nih.gov/32649182
Autor:
David G. Wernick, Michael Klutstein, Roni Rak, Shannon M. Johnson, Andreas Mershin, Daniel Schultz, Simmie L. Foster, Sibylle C. Vonesch, Yinon M. Bar-On, Daniel Schraivogel, Jeffrey E. Gerst, Olga Snitser, Yitzhak Pilpel, Katarzyna P. Adamala, Dmitry Zabezhinsky, Idan Yelin, Atray Dixit, Markus Ralser, Bianca P. Hennig, Orna Dahan, Dvir Schirman, Dikla Levi, Aditya M. Kunjapur, Roy Kishony, Sivan Kaminski Strauss, Bede P. Busby, Joseph M. Georgeson, Omri Adini, Ghil Jona, Alex N. Nguyen Ba, Ronen Hazan, Shira Nouriel, Lars M. Steinmetz, Timothy Stiles, Tal Dagan, Timothy M. Wannier, William F. Mueller, Thrasyvoulos Karydis, Csaba Pál, Ehud Sass, Noah Jakimo, Marc Rübsam, George M. Church, Alice Flint, Tanita Wein, Prashant Kumar, Nilima Walunjkar, Viridiana Olin-Sandoval, Aaron N. Brooks, Dor Russ, Andras Solt, Iftach Nachman, Einat Shaer Tamar, Michael M. Desai, Bálint Csörgő, Noa Aharon Hefetz, Rachel Soo Hoo Smith, Deepa Agashe, Razi Zeidan, Ning Yin, Emmanuel D. Levy, Elad Herz, Avihu H. Yona
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 3, p e3000182 (2019)
PLoS Biology, Vol 17, Iss 3, p e3000182 (2019)
In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c2152f7a9827795b86493d0005a3c5
Autor:
Yehudit Zohar, Shmuel Gleizer, Ghil Jona, Dan Davidi, Tasneem Bareia, Ido Shani, Niv Antonovsky, Naama Tepper, Uri Barenholz, Arren Bar-Even, Ron Milo, Sergey Malitsky, Elad Noor, Elad Herz, Yinon M. Bar-On, Lior Zelcbuch, Shira Amram, David G. Wernick, Aryeh Wides
Publikováno v:
Cell
Summary Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive grand challenge. Here, we demonstrate how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6a546f218e84f0ba36bbc2a29db4fc
Autor:
Shmuel Gleizer, Alon Savidor, Uri Barenholz, Ron Milo, Yinon M. Bar-On, Lianet Noda-García, Dan Davidi, David G. Wernick, Yehudit Zohar, Elad Herz, Keren Lyn Frisch, Noam Prywes, Niv Antonovsky
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Understanding the evolution of a new metabolic capability in full mechanistic detail is challenging, as causative mutations may be masked by non-essential "hitchhiking" mutations accumulated during the evolutionary trajectory. We have previously used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50780a45d1e5faa079321d1c0511f881
http://europepmc.org/articles/PMC5700066
http://europepmc.org/articles/PMC5700066
Publikováno v:
Metabolic Engineering. 23:53-61
The non-recyclable use of nitrogen fertilizers in microbial production of fuels and chemicals remains environmentally detrimental. Conversion of protein wastes into biofuels and ammonia by engineering nitrogen flux in Escherichia coli has been demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11114905310714f0f8f4beac3036801c
https://doi.org/10.1016/j.ymben.2014.02.007
https://doi.org/10.1016/j.ymben.2014.02.007
Publikováno v:
Scientific Reports
Contamination susceptibility, water usage and inability to utilize 5-carbon sugars and disaccharides are among the major obstacles in industrialization of sustainable biorefining. Extremophilic thermophiles and acidophiles are being researched to com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8e637fe778363e62213a2a8dbd75a6
http://europepmc.org/articles/PMC4735285
http://europepmc.org/articles/PMC4735285
Autor:
James V Petersen, Christopher D. Hein, Elizabeth M. Doherty, David G. Wernick, John W. Eschelbach, Marian C. Bryan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1141-1149 (2011)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
The performance of the ThalesNano H-Cube®, a commercial packed bed flow hydrogenator, was evaluated in the context of small scale reaction screening and optimization. A model reaction, the reduction of styrene to ethylbenzene through a 10% Pd/C cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67e62dfcb4f4a8cdce80a0b4d6c6110
https://doi.org/10.3762/bjoc.7.132
https://doi.org/10.3762/bjoc.7.132
Autor:
Kwon-Young Choi, Jimmy G. Lafontaine Rivera, James C. Liao, David G. Wernick, Christine A. Tat
Publikováno v:
Genome Announcements
Bacillus marmarensis strain DSM 21297 is an extreme obligate alkaliphile able to grow in medium up to pH 12.5. A whole-shotgun strategy and de novo assembly led to the generation of a 4-Mbp genome of this strain. The genome features alkaliphilic adap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca7aa1f39909c1cf1d87da37206dee5
http://europepmc.org/articles/PMC3869328
http://europepmc.org/articles/PMC3869328
Publikováno v:
New Biotechnology. 33:S14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f97eda9e7494c23534b73441a32db77
https://doi.org/10.1016/j.nbt.2016.06.773
https://doi.org/10.1016/j.nbt.2016.06.773