Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David G. Ramirez"'
Autor:
Nikki L. Farnsworth, Robert A. Piscopio, Wolfgang E. Schleicher, David G. Ramirez, Jose G. Miranda, Richard K. P. Benninger
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca2+ homeostasis. Connexin36 (Cx36) gap junctions electrically couple β-cells to coordinate glucose-stimulated C
Externí odkaz:
https://doaj.org/article/8f6e7598ecc54d338d5d6e9c9e2a84a0
Autor:
Arjun K. Fontaine, David G. Ramirez, Samuel F. Littich, Robert A. Piscopio, Vira Kravets, Wolfgang E. Schleicher, Naoko Mizoguchi, John H. Caldwell, Richard F. ff. Weir, Richard K. P. Benninger
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Previous studies have demonstrated stimulation of endocrine pancreas function by vagal nerve electrical stimulation. While this increases insulin secretion, expected concomitant reductions in circulating glucose do not occur. A complicating
Externí odkaz:
https://doaj.org/article/a57569d33df4487d82b410837e3941d0
Autor:
Jose G. Miranda, Wolfgang E. Schleicher, Kristen L. Wells, David G. Ramirez, Samantha P. Landgrave, Richard K.P. Benninger
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101430- (2022)
Objective: Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+
Externí odkaz:
https://doaj.org/article/d0549562ce464fd2ac0dc8e8f0befa0f
Autor:
David G. Ramirez, Eric Abenojar, Christopher Hernandez, David S. Lorberbaum, Lucine A. Papazian, Samantha Passman, Vinh Pham, Agata A. Exner, Richard K. P. Benninger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Infiltration of immune cells to the pancreatic islets precedes clinical symptoms of type 1 diabetes, and lack of methods to detect this insulitis impedes early interventions. Here the authors report a contrast enhanced ultrasound method that can dete
Externí odkaz:
https://doaj.org/article/ea834bcc10ac40038a26340fb8b2edc0
Publikováno v:
Plants, Vol 4, Iss 1, Pp 63-84 (2015)
A considerable amount of research has been conducted to determine how cell walls are loosened to produce irreversible wall deformation and expansive growth in plant and algal cells. The same cannot be said about fungal cells. Almost nothing is known
Externí odkaz:
https://doaj.org/article/8be33e3fa4c5498dbd846152ff999d98
Publikováno v:
Ultrasound Med Biol
In type1 diabetes (T1D) immune-cell infiltration into islets of Langerhans (insulitis) and β-cell decline occurs years before diabetes presents. There is a lack of validated clinical approaches for detecting insulitis and β-cell decline, to diagnos
Autor:
Ji Hye Chun, Melissa M. Henckel, Leslie A. Knaub, Sara E. Hull, Greg B. Pott, David G. Ramirez, Jane E.-B. Reusch, Amy C. Keller
Publikováno v:
Planta medica. 88(9-10)
Diabetes is a life-threatening and debilitating disease with pathological hallmarks, including glucose intolerance and insulin resistance. Plant compounds are a source of novel and effective therapeutics, and the flavonoid (−)-epicatechin, common t
Autor:
Matthew R. Lowerison, Alec N. Thomas, Mark A. Borden, Kang-Ho Song, Todd W. Murray, Awaneesh Upadhyay, Pengfei Song, David G. Ramirez, Virginie Papadopoulou, Richard K.P. Benninger
Publikováno v:
Langmuir
Nanodrops comprising a perfluorocarbon liquid core can be acoustically vaporized into echogenic microbubbles for ultrasound imaging. Packaging the microbubble in its condensed liquid state provides some advantages, including in situ activation of the
Autor:
Vinh Pham, David G. Ramirez, Awaneesh Upadhyay, M. Ciccaglione, Mark A. Borden, Richard K.P. Benninger
Publikováno v:
Proc Natl Acad Sci U S A
Type 1 diabetes (T1D) results from immune infiltration and destruction of insulin-producing β-cells within the pancreatic islets of Langerhans (insulitis), resulting in loss of glucose homeostasis. Early diagnosis during pre-symptomatic T1D would al
Autor:
Jose G, Miranda, Wolfgang E, Schleicher, Kristen L, Wells, David G, Ramirez, Samantha P, Landgrave, Richard K P, Benninger
Publikováno v:
Molecular Metabolism
Objective Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+