Zobrazeno 1 - 10 of 60 pro vyhledávání: '"David G. Motto"'
1
ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model
Autor: X. Long Zheng, Michelle Thiboutot, Douglas B. Cines, Mortimer Poncz, Khalil Bdeir, David G. Motto, Lenka Yunk, Stephen Kacir, Eric M. Ostertag, Vincent Hayes, Don L. Siegel, Gayathri Gulendran
Publikováno v: Transfusion. 56:1775-1785
BACKGROUND Acquired thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disease in which ultralarge von Willebrand factor (UL-VWF) multimers accumulate as a result of autoantibody inhibition of the VWF protease, ADAMTS13. Current treatme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d55f00131822853ee04617b9e9e363cc
https://doi.org/10.1111/trf.13583
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2
Red blood cells mediate the onset of thrombosis in the ferric chloride murine model
Autor: Gilbert V. Schaeffer, Anil K. Chauhan, Jessica K. Hansen, David G. Motto, Justin D. Barr
Publikováno v: Blood. 121:3733-3741
Application of ferric chloride (FeCl(3)) to exposed blood vessels is widely used to initiate thrombosis in laboratory mice. Because the mechanisms by which FeCl(3) induces endothelial injury and subsequent thrombus formation are little understood, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb268f32a7684697ab865893ebc57713
https://doi.org/10.1182/blood-2012-11-468983
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3
Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursorcells
Autor: David G. Motto, Joshua M. Madsen, David K. Meyerholz, Adam J. Case, Frederick E. Domann
Publikováno v: Free Radical Biology and Medicine. 56:17-27
Heme synthesis partially occurs in the mitochondrial matrix, thus there is a high probability that enzymes and intermediates important in the production of heme will be exposed to metabolic byproducts including reactive oxygen species. In addition, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf7cc4b72a08ab0905c2d066497b2dc
https://doi.org/10.1016/j.freeradbiomed.2012.11.018
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4
ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice
Autor: Melissa Jensen, Steven R. Lentz, Chintan Gandhi, David G. Motto, Anil K. Chauhan
Publikováno v: Blood. 120:5224-5230
Abstract 264 Background and objective: ADAMTS13 (A Disintegrin And Metalloprotease with Thrombospondin type I repeats-13) cleaves von Willebrand factor (VWF), a large multimeric protein that plays an important role in thrombus formation by binding to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01508fe804ff86286f5f51e0cd23f0d2
https://doi.org/10.1182/blood-2012-06-440255
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5
Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura
Autor: A. Kopić, M. Le Besnerais, Julie Favre, Lionel Nicol, Paul Mulder, Jérémie Martinet, David G. Motto, Paul Coppo, Ygal Benhamou, Agnès Veyradier, Hervé Levesque, Cécile V. Denis, Vincent Richard
Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Wiley, 2016, 14 (10), pp.1917-1930. ⟨10.1111/jth.13439⟩
Background Thrombotic thrombocytopenic purpura (TTP) is a life-threatening illness caused by deficiency of the Von Willebrand factor (VWF) cleaving protease ADAMTS13. Endothelial injury is believed to be a key initiating event in the pathogenesis lea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7ca432c7e438f2b95e72ed58b2ee3f
https://www.hal.inserm.fr/inserm-02296620
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6
ADAMTS13 Autoantibodies Cloned from Patients with Acquired Thrombotic Thrombocytopenic Purpura: 2. Pathogenicity in an animal model
Autor: Eric M, Ostertag, Khalil, Bdeir, Stephen, Kacir, Michelle, Thiboutot, Gayathri, Gulendran, Lenka, Yunk, Vincent M, Hayes, David G, Motto, Mortimer, Poncz, X Long, Zheng, Douglas B, Cines, Don L, Siegel
Acquired thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disease in which ultralarge von Willebrand factor (UL-VWF) multimers accumulate as a result of autoantibody inhibition of the VWF protease, ADAMTS13. Current treatment is not s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ea4ef28116972866b8015b71ae6bbafb
https://europepmc.org/articles/PMC4938757/
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7
ADAMTS13 reduces VWF‐mediated acute inflammation following focal cerebral ischemia in mice
Autor: Steven R. Lentz, Mohammad Moshahid Khan, David G. Motto, Anil K. Chauhan
Publikováno v: Journal of Thrombosis and Haemostasis. 10:1665-1671
Summary. Background: ADAMTS13 cleaves hyperactive ultra-large von Willebrand factor (ULVWF) multimers into smaller and less active forms. It remains unknown whether VWF-mediated inflammatory processes play a role in the enhanced brain injury due to A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ba372f5c8c9b1558d3097d6eadba9e
https://doi.org/10.1111/j.1538-7836.2012.04822.x
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8
Alternatively-Spliced Extra Domain A of Fibronectin Promotes Acute Inflammation and Brain Injury After Cerebral Ischemia in Mice
Autor: David G. Motto, Neelam Chauhan, Mohammad Moshahid Khan, Chintan Gandhi, Jeff W. Stevens, Steven R. Lentz, Anil K. Chauhan
Publikováno v: Stroke. 43:1376-1382
Background and Purpose— The fibronectin isoform containing the alternatively spliced extra domain A (EDA + -FN) is normally absent from the circulation, but plasma levels of EDA + -FN can become markedly elevated in several human pathological condi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f2171262d23016cf3287baaa324acd
https://doi.org/10.1161/strokeaha.111.635516
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9
Blood group O and black race are independent risk factors for thrombotic thrombocytopenic purpura associated with severe ADAMTS13 deficiency
Autor: Bernhard Lämmle, Johanna A. Kremer Hovinga, Sara K. Vesely, Deirdra R. Terrell, David G. Motto, James N. George
Publikováno v: Transfusion. 51:2237-2243
BACKGROUND It has been postulated that blood group O subjects may be partially protected against thrombotic thrombocytopenic purpura (TTP) because they have lower plasma levels of von Willebrand factor (VWF).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4bd9aa8f44aa34c4899d43369eb3d27
https://doi.org/10.1111/j.1537-2995.2011.03125.x
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10
von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture
Autor: David G. Motto, Nicolas Lerolle, Cécile V. Denis, I. Badirou, Dominique Baruch, Patrick Bruneval, C. Dunois-Lardé, Gary S. Hill, JL Diehl
Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Wiley, 2009, 7 (5), pp.843-850. ⟨10.1111/j.1538-7836.2009.03313.x⟩
Journal of Thrombosis and Haemostasis, 2009, 7 (5), pp.843-850. ⟨10.1111/j.1538-7836.2009.03313.x⟩
International audience; Summary. Background: During sepsis, von Willebrand factor (VWF) is abundantly secreted; the main mechanism regulating its size involves specific proteolysis by the metalloprotease ADAMTS-13. Objectives: To determine whether AD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41f6c7473f7ba7ee941d3bb5c011c3a
https://doi.org/10.1111/j.1538-7836.2009.03313.x
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