Zobrazeno 1 - 10
of 37
pro vyhledávání: '"David G. Melillo"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 52:514-517
A neurokinin (NK-1) receptor antagonist, [14C]Aprepitant, was synthesized using two labeled olefination reagents: [14C]dimethyltitanocene 1 and [14C]methyl (methyltrimethylsilyl)titanocene 7. Both reagents can be readily prepared from [14C]methyllith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1312797c8aa5f27e733412b4f9c28496
https://doi.org/10.1002/jlcr.1667
https://doi.org/10.1002/jlcr.1667
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:629-633
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196bda926c1eb57ea186ad8227b8c459
https://doi.org/10.1002/jlcr.1394
https://doi.org/10.1002/jlcr.1394
Autor:
Dennis C. Dean, Dan Yao, Cheng-yi Chen, Charles S. Elmore, Michael A. Wallace, Jonathan Z. Ho, David G. Melillo, Matthew P. Braun
Publikováno v:
Helvetica Chimica Acta. 88:1040-1047
A simple, high-yielding synthesis of dibutyl[14C]formamide ([14C]DBF; 1) from 14CO2 was developed (Scheme 1): reaction of LiBEt3H and 14CO2 followed by aqueous workup gave H14CO2H in high yield. Conversion of the [14C]formic acid to 1 was effected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3ea975b3fff1fcccf9c81de730070ca
https://doi.org/10.1002/hlca.200590075
https://doi.org/10.1002/hlca.200590075
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:275-283
A new synthetic methodology that captures electrophilic 35S8 with aryl Grignard reagents or lithiates provides entry to a wide variety of [35S]aryl sulfonyl chlorides upon oxidation and chlorination. Copyright © 2005 John Wiley & Sons, Ltd.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2ce6ef1411427ff1d72ecaa3deee8b
https://doi.org/10.1002/jlcr.920
https://doi.org/10.1002/jlcr.920
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:203-208
A method for scavenging excess amines in sulfur-35-labeled radioligand preparations using fluorous scavengers has been developed in an effort to simplify the purification. This fluorous scavenging has been shown to be effective at removing excess ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026984709e869e7a9f7994d4d2a5fddc
https://doi.org/10.1002/jlcr.915
https://doi.org/10.1002/jlcr.915
Autor:
Herbert J. Jenkins, David G. Melillo, Dennis C. Dean, Anson Chang, Michael A. Wallace, Matthew P. Braun, Allen N. Jones, Xiujuan Jia, Louis S. Crocker, Rosemary Marques, David J. Schenk, Dan Yao
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 47:399-406
High-intensity ultrasonic treatment of MeOH/H2O, IPA/H2O, EtOH or H2O suspensions of C-14 labeled and unlabeled pharmaceuticals successfully reduced the average particle diameter from a range of 8–260 to 4–15 µm as determined by optical microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8af790e2d38cc7fdd64dc7d834d43b3e
https://doi.org/10.1002/jlcr.826
https://doi.org/10.1002/jlcr.826
Autor:
Matthew P. Braun, Dennis C. Dean, Jonathan Z. Ho, Ying‐Duo Gao, Raju Subramanian, David G. Melillo
Publikováno v:
Helvetica Chimica Acta. 87:674-681
In support of a research program aimed at discovering orally bioavailable thrombin inhibitors, 13C- labeled 3-aminopyrazinone acetamide thrombin inhibitors have been prepared to aid in the structural elucidation of key metabolites during preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2715a69242fa0a2e86eea53eaeacb33
https://doi.org/10.1002/hlca.200490063
https://doi.org/10.1002/hlca.200490063
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 47:115-125
Radiolabeled tracers were required for the development of a series of VLA-4 antagonists. A method to synthesize [U-14C]3,5-dichlorobenzenesulfonyl chloride was developed. From this key intermediate, various tracers were prepared in high yield. Copyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37526f6cfba60860af83fb666e7b2f23
https://doi.org/10.1002/jlcr.804
https://doi.org/10.1002/jlcr.804
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 46:993-1000
In support of a program to develop a new gonadotropin releasing hormone (GnRH) receptor antagonist, two 14C labelled candidate tracers, 14C-1 and 14C-2, were synthesized for utilization in metabolism studies. A slight modification of the Medicinal Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3ad1ab39f241e4254f0ab08342f88b
https://doi.org/10.1002/jlcr.733
https://doi.org/10.1002/jlcr.733
Autor:
Dennis C. Dean, Herb Jenkins, Yong Zhang, Carter Gibson, Allen N. Jones, David G. Melillo, Charles S. Elmore
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:29-36
Stable label analogues of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) were required for use as internal standards for LC/MS quantitation. A minimum incorporation of stable isotopes to produce a mass increase of 3 in the non-glutamate deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42fac719451577f107477f90dafd50c8
https://doi.org/10.1002/jlcr.537
https://doi.org/10.1002/jlcr.537