Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David G. Loughhead"'
Autor:
Mary E. Gerritsen, Dane Karr, Ken A. Brameld, Timothy D. Owens, Vernon T. Phan, Jens Oliver Funk, Eleni Venetsanakos, David G. Loughhead, Tony Ton, Danny Tam, David Michael Goldstein, Erik Verner, Jin Shu, Kwan Leung, Jacob LaStant, J. Michael Bradshaw
Publikováno v:
Journal of Medicinal Chemistry. 60:6516-6527
Aberrant signaling of the FGF/FGFR pathway occurs frequently in cancers and is an oncogenic driver in many solid tumors. Clinical validation of FGFR as a therapeutic target has been demonstrated in bladder, liver, lung, breast, and gastric cancers. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87eb832fe7ef7eed3e087cac6857df2b
https://doi.org/10.1021/acs.jmedchem.7b00360
https://doi.org/10.1021/acs.jmedchem.7b00360
Autor:
Timothy D. Owens, Mary E. Gerritsen, Ronald J. Hill, David G Loughhead, J. Michael Bradshaw, Erik Verner, Dane Karr, David Michael Goldstein, Jesse M. McFarland, Vernon T. Phan, Angelina Bisconte, Vaishali Patel, Philip A. Nunn, Jens Oliver Funk, Jin Shu, David Finkle, Danny Tam, Tony Ton, Ken A. Brameld, Ville O. Paavilainen, Xiaoyan Li, Jack Taunton, Sergei Romanov
Publikováno v:
Nature chemical biology, vol 11, iss 7
Nature chemical biology
Nature chemical biology
Drugs with prolonged, on-target residence time often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking. Here, we demonstrate progress toward this elusive goal by targeting a noncatalytic cysteine in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83acadbd6e4eba9e99e2adc9c4909438
https://escholarship.org/uc/item/45z2k97q
https://escholarship.org/uc/item/45z2k97q
Autor:
Francisco Xavier Talamas, David J. Morgans, David Bernard Smith, Robert James Weikert, David G. Loughhead, Fidencio Franco, Alicia Cervantes, Serena T. Cutler
Publikováno v:
Tetrahedron Letters. 38:4725-4728
Florisil ® was found to be effective in promoting the [1,3]-sigmatropic shift of mycophenolic acid related allyl phenyl ethers. Several novel mycophenolic acid analogues were thus prepared. Through a crossover experiment using two deuterated analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2810c42e96c5dd10bab03e0db77e86fa
https://doi.org/10.1016/s0040-4039(97)00949-0
https://doi.org/10.1016/s0040-4039(97)00949-0
Autor:
Carlos Gonzalez, Stephen F. Carr, Elsie M. Eugui, Rebecca A. Stephenson, Fidencio Franco, Peter H. Nelson, Ann-Marie Waltos, Eric Brian Sjogren, Sussan Rouhafza, Francisco Xavier Talamas, Ronald Charles Hawley, Devens Bruce H, David G. Loughhead, Robert James Weikert, Patterson John W, Eva Papp, David J. Milan, John C. Wu, David Bernard Smith
Publikováno v:
Journal of Medicinal Chemistry. 39:4181-4196
Structure-activity relationships in the region of the phthalide ring of the inosine monophosphate dehydrogenase inhibitor mycophenolic acid have been explored. Replacement of the lactone ring with other cyclic moieties resulted in loss of potency, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff036a2797b977cf77932866612aa31
https://doi.org/10.1021/jm9603633
https://doi.org/10.1021/jm9603633
Autor:
David J. Morgans, and John O. Link, Rong-rong Zhu‡, David Bernard Smith, David G. Loughhead, Robert James Weikert, John C. Rohloff, Waltos Ann Marie
Publikováno v:
The Journal of Organic Chemistry. 61:2236-2241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a506bdaaba3f1ecef2ab5a5ad89b21
https://doi.org/10.1021/jo951883t
https://doi.org/10.1021/jo951883t
Autor:
J. C. Rohloff, D. B. Smith, Robert James Weikert, D. J. Jun. Morgans, Waltos Ann Marie, David G. Loughhead, J. O. Link, R. Zhu
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f1c62ac8e393275dec10ce815fedef7
https://doi.org/10.1002/chin.199631110
https://doi.org/10.1002/chin.199631110
Autor:
André deRosier, David G. Loughhead, David Mark Rotstein, Shelley K. Gleason, Eun Kyung Lee, Fernando Padilla, Lina Setti, Dick Cournoyer, Remy Lemoine, Cheng-I. Mau, Paul Weller, Andreas Jekle, Jutta Wanner, Pamela Berry, Chris Richard Melville, Marianna Dioszegi, Ann C. Petersen, Surya Sankuratri, Jason Manka, Changhua Ji, Lin Xiao-Fa, Lijing Chen, Gabrielle Heilek, Lubov Filonova
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757bbb465169e0977e2a95f17e17d1e6
https://pubmed.ncbi.nlm.nih.gov/20417098
https://pubmed.ncbi.nlm.nih.gov/20417098
Publikováno v:
Journal of Natural Products. 54:1509-1515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d1c65c1dd75c494555135b4b763fdbf
https://doi.org/10.1021/np50078a004
https://doi.org/10.1021/np50078a004
Publikováno v:
The Journal of Organic Chemistry. 64:3373-3375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01b4405cfc20f25f9c7edba0f502ee9
https://doi.org/10.1021/jo982287c
https://doi.org/10.1021/jo982287c
Autor:
David Smith, Daisy Joe Du Bois, Sunil Sahdeo, David G. Loughhead, Hans Maag, Jason Manka, Dinah Misner
Publikováno v:
Biochemical Pharmacology. 78:913
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a406029e7bc9bb6f947dc64901021fbc
https://doi.org/10.1016/j.bcp.2009.06.063
https://doi.org/10.1016/j.bcp.2009.06.063