Zobrazeno 1 - 10
of 31
pro vyhledávání: '"David G. Kaiser"'
Publikováno v:
ChemInform. 24
Structure maps are presented as an efficient means of indicating structure-reactivity relationships in metabolic pathway databases. The relative occurrence of N-demethylation and N-oxidation of N-methyl tertiary amines was examined using the structur
Publikováno v:
Journal of Chemical Information and Computer Sciences. 32:591-599
Structure maps are presented as an efficient means of indicating structure-reactivity relationships in metabolic pathway databases. The relative occurrence of N-demethylation and N-oxidation of N-methyl tertiary amines was examined using the structur
Autor:
Mark P. Grillo, Jeffrey R. Stephens, Wade J. Adams, David J. Porubek, David G. Kaiser, Thomas A. Baillie, Susan M. Sanins, Gordon W. Halstead
Publikováno v:
Biochemical Pharmacology. 42:R1-R4
Publikováno v:
Journal of cardiovascular pharmacology. 20(2)
Summary U74006F, a novel new 21-aminosteroid inhibitor of lipid peroxidation, has been effective in preventing free-radical-mediated injury in central nervous system models. To assess its ability to diminish myocardial injury due to ischemia and repe
Publikováno v:
Annals of Plastic Surgery. 24:100
The long-term fate of 6-alpha-methyl-methylprednisolone hemisuccinate (MPHS) placed into breast prostheses prior to implantation in humans was determined. MPHS hydrolyzes to the active form 6-alpha-methylprednisolone (MP) in water, which then diffuse
Autor:
Garrett J. Vangiesse, David G. Kaiser
Publikováno v:
Journal of Pharmaceutical Sciences. 64:798-801
To study the behavior of the d- and l-isomers of ibuprofen in humans, a method for the determination of the individual enantiomers in plasma and urine was required. A specific procedure was developed based on (a) benzene extraction of the acidified s
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1713-1716
Plasma level data on two investigational capsule formulations of propoxyphene with similar physicochemical parameters demonstrate that the formulations have different in vivo bioavailabilities. The potential for bioavailability problems with water-so
Publikováno v:
Gastroenterology. 97:1147-1158
We investigated the mechanism by which exposure to cold sensitizes rats to the formation of gastric lesions after a low dose of aspirin (50 mg/kg). Six times more lesions were produced by aspirin plus cold than by aspirin alone. Three hypotheses were
Radioimmunoassay for medroxyprogesterone acetate (Provera®) using the 11α-hydroxy succinyl conjugate
Publikováno v:
Steroids. 23:713-730
A radioimmunoassay was developed for medroxyprogesterone acetate (MPA; Provera®) employing rabbit antibodies made against a bovine serum albumin (BSA) conjugate of the hemisuccinate ester of 11α-hydroxy MPA. The 11α-hydroxyl group was introduced i
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 434:135-143
To evaluate the pharmacokinetics and drug availability from various dosage formulations, a method for the determination of guanadrel, (1,4-dioxaspiro[4,5]dec-2-ylmethyl)guanidine, in plasma and urine was required. a gas chromatographic procedure, bas