Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David G. Hassall"'
Autor:
Mark Baumert, Arne Fütterer, Laura Tomlinson, Jens Fuchser, Andrew West, Peter S. Marshall, David G. Hassall
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:995-1003
RATIONALE The signal intensity of a given molecule across a tissue section when measured using mass spectrometry imaging (MSI) is prone to changes caused by the molecular heterogeneity across the surface of the tissue. Here we propose a strategy to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70270c1596ac9660eb8c2d62772ed8ae
https://doi.org/10.1002/rcm.6869
https://doi.org/10.1002/rcm.6869
Autor:
Robert A. Ngala, Andrew N. Billin, Timothy M. Willson, A. G. Roy, Claire J. Stocker, Jonathan R.S. Arch, David G. Hassall, Michael A. Cawthorne, J. D. Harling, David C. Hislop, Edward T. Wargent, R. Bell
Publikováno v:
Diabetes, Obesity and Metabolism. 13:455-464
Aim We investigated how GW800644, the first pharmacologically selective murine peroxisome proliferator-activated receptor δ (PPARδ) agonist, affects energy balance, glucose homeostasis and fuel utilization by muscle in obese mice. Methods Potencies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474977a09e929c5ab0f086f61cb6bb10
https://doi.org/10.1111/j.1463-1326.2011.01371.x
https://doi.org/10.1111/j.1463-1326.2011.01371.x
Autor:
Dennis L. Sprecher, Barbara A. Fielding, Stephen O'Rahilly, Keith N. Frayn, Duncan Richards, Samar Basu, Fredrik Karpe, Priti S. Hegde, Timothy M. Willson, Peter R. Murgatroyd, Zeke Fang, Niall R. Moore, Jay Strum, Theodore M. Danoff, Leli Sarov-Blat, Jane Cheeseman, Pauline Sutton, David G. Hassall, Sandy M. Humphreys, Eric Olson, Ulf Risérus, Tony G. Johnson, Aixue Liu, Sandra Hirschberg
Publikováno v:
Diabetes. 57:332-339
OBJECTIVE— Pharmacological use of peroxisome proliferator–activated receptor (PPAR)δ agonists and transgenic overexpression of PPARδ in mice suggest amelioration of features of the metabolic syndrome through enhanced fat oxidation in skeletal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501cd118af2c29620b3e29bd31a1edc2
https://doi.org/10.2337/db07-1318
https://doi.org/10.2337/db07-1318
Autor:
Christine Reynet, David G. Hassall, Emily L. Abbot, Kevin W. Buchan, Stephen J. Yeaman, James G. McCormack
Publikováno v:
FEBS Journal. 272:3004-3014
The pyruvate dehydrogenase complex occupies a central and strategic position in muscle intermediary metabolism and is primarily regulated by phosphorylation/dephosphorylation. The identification of multiple isoforms of pyruvate dehydrogenase kinase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf2befd6f9103ef906a36c1239b7749
https://doi.org/10.1111/j.1742-4658.2005.04713.x
https://doi.org/10.1111/j.1742-4658.2005.04713.x
Autor:
Anita K. Stannard, Silke Schepelmann, Michael L. Roberts, Ian R. Graham, George Dickson, Julian D. Harris, David G. Hassall, Vanessa J. Hill, Bradley L. Hodges, James S. Owen, Andrea Amalfitano
Publikováno v:
Human Molecular Genetics. 11:43-58
Apolipoprotein E (apoE) is a 34 kDa glycoprotein with multiple actions that help protect against the development of atherosclerosis. Here, we have assessed the atheroprotective potential of an [E1(-), E3(-), polymerase(-)] adenovirus vector expressin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87809dae0e990bb4c2d90d12e576be8
https://doi.org/10.1093/hmg/11.1.43
https://doi.org/10.1093/hmg/11.1.43
Autor:
Zahra Mohri, Julian D. Harris, Silke Schepelmann, David G. Hassall, Ian R. Graham, A.K. Stannard, George Dickson, Hill, James S. Owen, Takis Athanasopoulos
Publikováno v:
Gene Therapy. 9:21-29
Apolipoprotein E (apoE) is a multifunctional plasma glycoprotein involved in lipoprotein metabolism and a range of cell signalling phenomena. ApoE-deficient (apoE(-/-)) mice exhibit severe hypercholesterolaemia and are an excellent model of human ath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1706a935dab5453345b7fde163492bc1
https://doi.org/10.1038/sj.gt.3301615
https://doi.org/10.1038/sj.gt.3301615
Autor:
Kevin W. Buchan, David G. Hassall
Publikováno v:
Medicinal Research Reviews. 20:350-366
Successful management of cardiovascular (CV) disease and associated metabolic syndromes, such as diabetes, is a major challenge to the clinician. Reducing CV risk factors, such as abnormal lipid profiles, insulin resistance or hypertension is the fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c34406382d24104ac53b89bf929279a8
https://doi.org/10.1002/1098-1128(200009)20:5<350::aid-med2>3.0.co
https://doi.org/10.1002/1098-1128(200009)20:5<350::aid-med2>3.0.co
Publikováno v:
Atherosclerosis. 135:193-204
One mechanism by which plasma high-density lipoprotein (HDL) may protect against atherogenesis is by inhibiting the oxidation of low-density lipoprotein (LDL). Recent evidence suggests that paraoxonase, an HDL-associated, calcium-dependent enzyme, ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e8875da8653cc8f69c6f28ad90690a
https://doi.org/10.1016/s0021-9150(97)00162-7
https://doi.org/10.1016/s0021-9150(97)00162-7
Autor:
Laura, Tomlinson, Jens, Fuchser, Arne, Fütterer, Mark, Baumert, David G, Hassall, Andrew, West, Peter S, Marshall
Publikováno v:
Rapid communications in mass spectrometry : RCM. 28(9)
The signal intensity of a given molecule across a tissue section when measured using mass spectrometry imaging (MSI) is prone to changes caused by the molecular heterogeneity across the surface of the tissue. Here we propose a strategy to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36b236ada984d63121906542621b1750
https://pubmed.ncbi.nlm.nih.gov/24677520
https://pubmed.ncbi.nlm.nih.gov/24677520
Autor:
Joel D. Parry, Joanne Kilgour, David G. Hassall, Mark Collinge, Chris Clarke, Kristen Nikula, Lea Ann Dailey, Ian Robinson, Matthew D. Reed, Joseph A. Dybowski, Curtis Maier, Raegan O'Lone, Ben Forbes, Rhys M. Jones, Deon Hildebrand, Alison Wolfreys, Lindsay Tomlinson, Anthony Cahn, Jan Klapwijk, Louise E. Donnelly, Philippa Pribul Allen, Tim McGovern
Publikováno v:
Advanced drug delivery reviews. 71
Alveolar macrophage (AM) responses are commonly induced in inhalation toxicology studies, typically being observed as an increase in number or a vacuolated ‘foamy’ morphology. Discriminating between adaptive AM responses and adverse events during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade5bfb3a3173aaff8e34114e414ff85
https://pubmed.ncbi.nlm.nih.gov/24530633
https://pubmed.ncbi.nlm.nih.gov/24530633