Zobrazeno 1 - 10
of 71
pro vyhledávání: '"David G. Hangauer"'
Autor:
Margaret T. Kasner, Molly B. Halloran, Jonathan Pan, Ellen K. Ritchie, Gerald J. Fetterly, Douglas Kramer, David G. Hangauer, James E. Thompson
Publikováno v:
Investigational New Drugs. 40:773-781
Background Poor tolerance to standard therapies and multi-drug resistance complicate treatment of elderly patients with acute myeloid leukemia (AML). It is therefore imperative to explore novel tolerable agents and target alternative pathways. KX2-39
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF file 196K, Figure S2. Effects of KX-01 and oxaliplatin on cell proliferation (Ki-67; A), angiogenesis (CD31; B), apoptosis (Cleaved caspase-3; C) RMUG-L model. Original magnification 200x . Bars in the graphs correspond sequentially to the labele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bb57f3e34ddb412dc7aad35a2281e0
https://doi.org/10.1158/1078-0432.22449806.v1
https://doi.org/10.1158/1078-0432.22449806.v1
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF file 176K, Figure S4. The effect of Src inhibitor or paclitaxel on cell survival. Cell survival was calculated as the number of cells surviving relative to the number of cells surviving in the control group. IC50 6 indicates median inhibitory rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1861f71930f749d1e56f539dfdf7b643
https://doi.org/10.1158/1078-0432.22449800
https://doi.org/10.1158/1078-0432.22449800
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF file 218K, Figure S5. (A) 72 proteins significantly differed between cells treated with KX-01 and control cells in RMUG-S cells. (B) 60 proteins significantly differed between cells treated with KX-01 and control cells in RMUG-L cells. (C) Wester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05e876b514ce96ff02f720612f5978e
https://doi.org/10.1158/1078-0432.22449797.v1
https://doi.org/10.1158/1078-0432.22449797.v1
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF file 162K, Figure S3. (A) MTT assay results showing the cytotoxicity of KX-01 at various concentrations in clear ovarian carcinoma cells. Cell viability was calculated as the number of cells surviving relative to the number of cells surviving in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7655a7a20ad3a827ba502e08b6d436cf
https://doi.org/10.1158/1078-0432.22449803
https://doi.org/10.1158/1078-0432.22449803
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF 116K, Figure S1. (A) Western blot results for p-paxillin and p-P130cas for the dose-finding experiment. HeyA8 cells were injected into the peritoneal cavity of 18 nude mice (2.5x105 cells per mouse). When tumors were palpable (4-5 weeks after the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145b73d019c4e513978e71219af4534f
https://doi.org/10.1158/1078-0432.22449809.v1
https://doi.org/10.1158/1078-0432.22449809.v1
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF file 106K, Table S1. Molecules whose expression significantly differed between cells treated with KX-01 and control cells in RMUG-S cells Table S2. Molecules whose expression significantly differed between cells treated with KX-01 and control cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57abccd4c76eb7063b9e3c554270be74
https://doi.org/10.1158/1078-0432.22449788
https://doi.org/10.1158/1078-0432.22449788
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
Purpose: To investigate the antitumor effects of targeting Src and tubulin in mucinous ovarian carcinoma.Experimental Design: The in vitro and in vivo effects and molecular mechanisms of KX-01, which inhibits Src pathway and tubulin polymerization, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0f528a0713014f9e1a89f0a64b374c
https://doi.org/10.1158/1078-0432.c.6521753
https://doi.org/10.1158/1078-0432.c.6521753
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF file 86K, Figure S7. (A) Western blot results showing PTEN expression in RMUG-S and RMUG-L cells. PTEN expression is null in the RMUG-L cells. (B) MTT assay results showing cytotoxicity of an Akt1/2 inhibitor in RMUG-S and RMUG-L cells exposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b94833f83b8729593d9863de025163
https://doi.org/10.1158/1078-0432.22449791
https://doi.org/10.1158/1078-0432.22449791
Autor:
Anil K. Sood, Michael Frumovitz, Robert L. Coleman, David G. Hangauer, Keith A. Baggerly, Gary E. Gallick, Cristina Ivan, Nicholas B. Jennings, Behrouz Zand, Justin Bottsford-Miller, Chad V. Pecot, Chunhua Lu, Yunfei Wen, Jian H. Song, Takahito Miyake, Sunila Pradeep, Yu Kang, Jie Huang, Hyun Jin Choi, Heather J. Dalton, Wei Hu, Tao Liu
PDF file 190K, Figure S6. (A, B) Glu-tubulin immunofluorescence staining (green) in RMUG-S and RMUG-L cells treated with 100 nM KX-01 for 24 hours and incubated with anti-glu-tubulin antibody followed by Alexa Fluor 488-conjugated anti-rabbit antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67c915adf70876b9386b6bdedf660f
https://doi.org/10.1158/1078-0432.22449794.v1
https://doi.org/10.1158/1078-0432.22449794.v1