Is there a symptomatic distinction between the affective psychoses and schizophrenia? A machine learning approach

Autor: Sameer Jauhar, Stephen M. Lawrie, Matthew M. Nour, Eve C. Johnstone, David G. Cunningham-Owens, Rajeev Krishnadas

Publikováno v: Jauhar, S, Krishnadas, R, Nour, M M, Cunningham-Owens, D, Johnstone, E C & Lawrie, S M 2018, ' Is there a symptomatic distinction between the affective psychoses and schizophrenia? A machine learning approach ', Schizophrenia Research . https://doi.org/10.1016/j.schres.2018.06.070

Dubiety exists over whether clinical symptoms of schizophrenia can be distinguished from affective psychosis, the assumption being that absence of a “point of rarity” indicates lack of nosological distinction, based on prior group-level analyses.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2691a9ed3683931c40bba0a5d9fa726
https://doi.org/10.1016/j.schres.2018.06.070

A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia

Autor: Andrew M. McIntosh, Eve C. Johnstone, Dominic Job, Heather C. Whalley, Enrico Simonotto, Stephen M. Lawrie, David G. Cunningham-Owens, Viktoria-Eleni Gountouna, Dominic Marjoram

Publikováno v: NeuroImage. 31:1850-1858

Theory of Mind (ToM) or mentalizing is the ability of individuals to determine the intentions and behavior of others. This ability is known to be compromised in schizophrenia and has been shown to fluctuate with symptom severity. Neuropsychological i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b750fd804d60b125f5b4c0146e7691bc
https://doi.org/10.1016/j.neuroimage.2006.02.011

A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

Autor: Ben J. Baig, Pippa A. Thomson, Stephen M. Lawrie, Dominic Job, David J. Porteous, David G. Cunningham-Owens, Andrew M. McIntosh, Kathryn L. Evans, Jeremy Hall, Heather C. Whalley, Eve C. Johnstone

Publikováno v: Nature neuroscience. 9(12)

NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c634ba1c597ac7ec7ce6569d3173323e
https://pubmed.ncbi.nlm.nih.gov/17072305

Functional imaging in subjects at high risk of schizophrenia

Autor: S.M. Lawrie, Heather C. Whalley, Nigel Goddard, Susanna Flett, Eve C. Johnstone, David G. Cunningham-Owens, Klaus P. Ebmeier, Heba Lakany, Ian Marshall, Enrico Simonotto

Publikováno v: SCHIZOPHRENIA RESEARCH. 60(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bde07b7c8ffa82e43c11d50b47791a5
http://ora.ox.ac.uk/objects/uuid:a58eb9c1-15ab-4dac-9d17-20d5b8439053

Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls

Autor: Sarah McConnell, Ian Marshall, Stephen M. Lawrie, Mark E. Bastin, David G. Cunningham-Owens, R.M. Steel, Jonathan J.K. Best, Eve C. Johnstone

Publikováno v: Psychiatry research. 106(3)

Several proton magnetic resonance spectroscopy (1H MRS) studies in schizophrenia have found reduced N-acetyl aspartate (NAA) concentrations in pre-frontal and temporal regions of the brain. Reductions in NAA may reflect abnormalities of neuronal stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0027f31237e40bd3964875a67b908b1e
https://pubmed.ncbi.nlm.nih.gov/11382538