Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David G. Courtney"'
Autor:
Connor G. G. Bamford, Lindsay Broadbent, Elihu Aranday-Cortes, Mary McCabe, James McKenna, David G. Courtney, Olivier Touzelet, Ahlam Ali, Grace Roberts, Guillermo Lopez Campos, David Simpson, Conall McCaughey, Derek Fairley, Ken Mills, Ultan F. Power, on behalf of the Breathing Together Investigators
Publikováno v:
Viruses, Vol 14, Iss 2, p 325 (2022)
SARS-CoV-2 can efficiently infect both children and adults, albeit with morbidity and mortality positively associated with increasing host age and presence of co-morbidities. SARS-CoV-2 continues to adapt to the human population, resulting in several
Externí odkaz:
https://doaj.org/article/7eb0dce777284585ab48e1334ebdc74c
Autor:
David G. Courtney, Andrea Chalem, Hal P. Bogerd, Brittany A. Law, Edward M. Kennedy, Christopher L. Holley, Bryan R. Cullen
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT While it has been known for several years that viral RNAs are subject to the addition of several distinct covalent modifications to individual nucleotides, collectively referred to as epitranscriptomic modifications, the effect of these edit
Externí odkaz:
https://doaj.org/article/680b9f08661b453e929e45ad6b3f64a7
Autor:
David G. Courtney
Publikováno v:
Cells, Vol 10, Iss 5, p 1129 (2021)
The field of mRNA modifications has been steadily growing in recent years as technologies have improved and the importance of these residues became clear. However, a subfield has also arisen, specifically focused on how these modifications affect vir
Externí odkaz:
https://doaj.org/article/4b318683942c4c10a168367814342aab
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006919 (2018)
Polyomaviruses are a family of small DNA tumor viruses that includes several pathogenic human members, including Merkel cell polyomavirus, BK virus and JC virus. As is characteristic of DNA tumor viruses, gene expression in polyomaviruses is temporal
Externí odkaz:
https://doaj.org/article/35a1f068873641f983028214e86325e8
Autor:
Bryan R. Cullen, Hal P. Bogerd, Cecilia Martínez-Campos, David G. Courtney, Christopher L. Holley, Kevin Tsai
Publikováno v:
RNA. 27:1400-1411
Pseudouridine ({psi}) is the most common non-canonical ribonucleoside present on mammalian non-coding RNAs (ncRNAs), including rRNAs, tRNAs and snRNAs, where it contributes ~7% of the total uridine level. However, {psi} constitutes only ~0.1% of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f5b7b4a3bf4c1875b3c690905a1f44
https://doi.org/10.1261/rna.078940.121
https://doi.org/10.1261/rna.078940.121
Autor:
Connor G G, Bamford, Lindsay, Broadbent, Elihu, Aranday-Cortes, Mary, McCabe, James, McKenna, David G, Courtney, Olivier, Touzelet, Ahlam, Ali, Grace, Roberts, Guillermo, Lopez Campos, David, Simpson, Conall, McCaughey, Derek, Fairley, Ken, Mills, Ultan F, Power, On Behalf Of The Breathing Together Investigators
Publikováno v:
Viruses; Volume 14; Issue 2; Pages: 325
Bamford, C, Broadbent, L, Aranday-Cortes, E, McCabe, M, McKenna, J, Courtney, D, Touzelet, O, Ali, A, Roberts, G C, Lopez Campos, G, Simpson, D, McCaughey, C, Fairley, D, Mills, K, Investigators, B T & Power, U 2022, ' Comparison of SARS-CoV-2 evolution in paediatric primary airway epithelial cell cultures compared with Vero-derived cell lines ', Viruses . https://doi.org/10.3390/v14020325
Bamford, C, Broadbent, L, Aranday-Cortes, E, McCabe, M, McKenna, J, Courtney, D, Touzelet, O, Ali, A, Roberts, G C, Lopez Campos, G, Simpson, D, McCaughey, C, Fairley, D, Mills, K, Investigators, B T & Power, U 2022, ' Comparison of SARS-CoV-2 evolution in paediatric primary airway epithelial cell cultures compared with Vero-derived cell lines ', Viruses . https://doi.org/10.3390/v14020325
SARS-CoV-2 can efficiently infect both children and adults, albeit with morbidity and mortality positively associated with increasing host age and presence of co-morbidities. SARS-CoV-2 continues to adapt to the human population, resulting in several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44778821d4bd1770c289f575f4f59c8
https://pubmed.ncbi.nlm.nih.gov/35215919
https://pubmed.ncbi.nlm.nih.gov/35215919
Autor:
Ultan F. Power, James McKenna, Conall McCaughey, Guillermo Lopez Campos, Grace C. Roberts, Ken I. Mills, Lindsay Broadbent, Olivier Touzelet, Elihu Aranday-Cortes, David Simpson, David G. Courtney, Connor G. G. Bamford, Mary McCabe, Derek Fairley, Ahlam A. Ali
SARS-CoV-2 continues to evolve, resulting in several ‘variants of concern’ with novel properties. The factors driving SARS-CoV-2 fitness and evolution in the human respiratory tract remain poorly defined. Here, we provide evidence that both viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f823f681b29033bc161258811938ea96
https://doi.org/10.1101/2021.07.16.452629
https://doi.org/10.1101/2021.07.16.452629
Autor:
Connor G. G. Bamford, Conall McCaughey, Sheerien Manzoor, Lindsay Broadbent, Ultan F. Power, Ahlam A. Ali, David G. Courtney, Olivier Touzelet, Ken I. Mills, Guillermo Lopez Campos
Publikováno v:
Broadbent, L, Bamford, C G G, Lopez Campos, G, Manzoor, S, Courtney, D, Ali, A, Touzelet, O, McCaughey, C, Mills, K & Power, U F 2022, ' An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells ', PLoS ONE, vol. 17, no. 4, e0266412 . https://doi.org/10.1371/journal.pone.0266412
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the coronavirus disease-19 (COVID-19) pandemic, was identified in late 2019 and went on to cause over 3.3 million deaths in 15 months. To date, targeted antiviral intervention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b124708d6f706c71a354a15eb2e0e064
https://doi.org/10.1371/journal.pone.0266412
https://doi.org/10.1371/journal.pone.0266412
Autor:
David G, Courtney, Kevin, Tsai, Hal P, Bogerd, Edward M, Kennedy, Brittany A, Law, Ann, Emery, Ronald, Swanstrom, Christopher L, Holley, Bryan R, Cullen
Publikováno v:
Cell Host Microbe
How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic modifications, alters mRNA function remains unclear. One issue has been the difficulty of quantifying these modifications. Using purified HIV-1 genomic RNA, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3855244c0937c900f6f069c089a5d52c
https://pubmed.ncbi.nlm.nih.gov/31415754
https://pubmed.ncbi.nlm.nih.gov/31415754
Autor:
Edward M. Kennedy, Kevin Tsai, Ann Emery, Ronald Swanstrom, Christopher L. Holley, Hal P. Bogerd, Brittany A. Law, Bryan R. Cullen, David G. Courtney
Publikováno v:
SSRN Electronic Journal.
How the covalent modification of individual mRNA nucleotides, termed epitranscriptomic modification, alters mRNA function remains unclear. One road block has been the difficulty of quantifying epitranscriptomic modifications. Using purified HIV-1 gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9337408ab20bd74b2fbaf0f36163d5
https://doi.org/10.2139/ssrn.3334977
https://doi.org/10.2139/ssrn.3334977