Výsledky vyhledávání - "David G. Barrett"

Akademický článek

Activation of the human insulin receptor by non-insulin-related peptides

Autor: Nicholas S. Kirk, Qi Chen, Yingzhe Ginger Wu, Anastasia L. Asante, Haitao Hu, Juan F. Espinosa, Francisco Martínez-Olid, Mai B. Margetts, Faiz A. Mohammed, Vladislav V. Kiselyov, David G. Barrett, Michael C. Lawrence

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

The regulation of plasma glucose levels is effected by insulin. Here, the authors reveal atomic detail of how peptides distinct from insulin bind to and activate the insulin receptor, with implications for design of small-molecule insulin mimetics.

Externí odkaz: https://doaj.org/article/1dab09f8cbff49e29577a56810f3b259

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Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors

Autor: Rongjun He, Jifeng Wang, Zhi-Hong Yu, Julie S. Moyers, M. Dodson Michael, Timothy B. Durham, Jeff W. Cramer, Yuewei Qian, Amy Lin, Li Wu, Nicholas Noinaj, David G. Barrett, Zhong-Yin Zhang

Publikováno v: J Med Chem

Protein tyrosine phosphatases constitute an important class of drug targets, whose potential has been limited by the paucity of drug-like small molecule inhibitors. We recently described a class of active site-directed, moderately selective and poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c61119301642263decda2d2789be67b
https://doi.org/10.1021/acs.jmedchem.2c01143

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Transition metal catalyzed oxidations, 3. Reaction of 4‐hydroxy[2.2]paracyclophane with the mimoun molybdenum oxodiperoxo complex [Mo(O 2 ) 2 O]· Py · HMPT

Autor: Karsten Krohn, Hagen Rieger, Henning Hopf, David G. Barrett

Publikováno v: Chemische Berichte. 123:1729-1732

A four-step preparation of dimethyl 7-oxobicyclo[2.2.1]-heptane-exo-2, exo-3-dicarboxylate (4) in satisfactory yield from the readily available 6,6-dimethylfulvene and maleic anhydride is described. Compound 4 represents a well-functionalized interme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d63e7b72221e100cad6780be95cef617
https://doi.org/10.1002/cber.19901230824

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Optical Resolution of [2,2]Paracyclophanes by High‐Performance Liquid Chromatography on Tris(3,5‐dimethylphenylcarbamates) of Celllulos and Amylose

Autor: Walter Gruhn, David G. Barrett, Henning Hopf, Yuriko Kaida, Yoshio Okamoto, Anton Gerdes, Joachim Hucker, Jörg Hibner

Publikováno v: Chemische Berichte. 123:841-845

Optical resolution of 22 [2,2]paracyclophane derivatives was examined by high-performance liquid chromatography (HPLC) using tris(3,5-dimethylphenylcarbamates) of cellulose and amylose as chiral stationary phases. Most compounds were completely separ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72babe26acb5f071217dbeb43db7cd8d
https://doi.org/10.1002/cber.19901230432

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Planar chiral systems, IV. An efficient route for the preparation of 5-formyl-4-hydroxy[2.2]paracyclophane (FHPC)

Autor: Henning Hopf, David G. Barrett

Publikováno v: Liebigs Annalen. 1995:449-451

For the preparation of the title compound, 4-hydroxy[2.2]paracyclophane (1) is first converted to the carbamate 2. Metalation of 2 with sec-butyllithium yields an ortho-anion which after trapping with dimethylformamide and acidic work-up provides 6 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f60b05256fa7d295affe537489977435
https://doi.org/10.1002/jlac.199519950259

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