Zobrazeno 1 - 10
of 91
pro vyhledávání: '"David G. Besselsen"'
Autor:
Irshad Ali Sheikh, Jared Bianchi-Smak, Daniel Laubitz, Gabriele Schiro, Monica T. Midura-Kiela, David G. Besselsen, Gayatri Vedantam, Sara Jarmakiewicz, Rafał Filip, Fayez K. Ghishan, Nan Gao, Pawel R. Kiela
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTAlthough the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been limited to reports of promoting the disease i
Externí odkaz:
https://doaj.org/article/1f11d92deb564e249b4081fe68ea04d4
Autor:
Mladen Jergović, Christopher P. Coplen, Jennifer L. Uhrlaub, David G. Besselsen, Shu Cheng, Megan J. Smithey, Janko Nikolich-Žugich
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6281004832a54b0e95315dc155589e76
Autor:
Daniel Laubitz, Michael A. Gurney, Monica Midura-Kiela, Christy Clutter, David G. Besselsen, Hao Chen, Fayez K. Ghishan, Pawel R. Kiela
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Dysregulation of intra- and extracellular pH in cancer contributes to extracellular matrix remodeling, favors cell migration, proliferation, and metastasis. Although the primary attention has been focused on the role of the ubiquitous Na+/H+
Externí odkaz:
https://doaj.org/article/8131be6d7bd141758894732769fe97c6
Autor:
Mladen Jergović, Christopher P. Coplen, Jennifer L. Uhrlaub, David G. Besselsen, Shu Cheng, Megan J. Smithey, Janko Nikolich-Žugich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Naïve T (Tn) cells require two homeostatic signals for long-term survival: tonic T cell receptor:self-peptide–MHC contact and IL-7 stimulation. However, how microbial exposure impacts Tn homeostasis is still unclear. Here we show that inf
Externí odkaz:
https://doaj.org/article/29b1820501044762b875464f250b653b
Autor:
Michael Daines, Rhea Pereira, Aubrey Cunningham, Barry Pryor, David G. Besselsen, Yuchen Liu, Qianwen Luo, Yin Chen
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Alternaria alternata is a ubiquitous fungus and a major allergen associated with the development of asthma. Inhalation of intact spores is the primary cause of human exposure to fungal allergen. However, allergen-rich cultured fungal filtrates are of
Externí odkaz:
https://doaj.org/article/0d004cd0c59f4422a7dcf722d01c20d3
Autor:
Natalia A. Ignatenko, Jennifer K. Barton, David G. Besselsen, Raymond B. Nagle, Edward R. Abril, Chiu-Hsieh Hsu, Hwudarw Chen, Mykella S. Jones, Kevin G. Ehrichs, Photini F.S. Rice
Supplementary Table 1. Statistical analysis of endpoints derived from histology. Number of animals in different groups is listed in Figure 1B. Supplementary Table 2. Statistical analysis of adenoma grade by genotypes in the subset of AOM-induced mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900123c2a40b6cd2dc97795afee6e000
https://doi.org/10.1158/1940-6207.22534889.v1
https://doi.org/10.1158/1940-6207.22534889.v1
Autor:
Natalia A. Ignatenko, Jennifer K. Barton, David G. Besselsen, Raymond B. Nagle, Edward R. Abril, Chiu-Hsieh Hsu, Hwudarw Chen, Mykella S. Jones, Kevin G. Ehrichs, Photini F.S. Rice
The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition and also showed its efficacy in prevention of sporadic colon adenomas. At the same time, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625d1b42be390a9a1d88c028ef1968e5
https://doi.org/10.1158/1940-6207.c.6547691.v1
https://doi.org/10.1158/1940-6207.c.6547691.v1
Autor:
David G. Besselsen, Christopher P. Coplen, Megan J. Smithey, Janko Nikolich-Žugich, Mladen Jergović, Jennifer L. Uhrlaub, Shu Cheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Naive T (Tn) cells require two homeostatic signals for long-term survival: tonic T cell receptor:self-peptide–MHC contact and IL-7 stimulation. However, how microbial exposure impacts Tn homeostasis is still unclear. Here we show that infections ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bf22bde14d9e24f271d340ca5948de
https://doaj.org/article/29b1820501044762b875464f250b653b
https://doaj.org/article/29b1820501044762b875464f250b653b
Publikováno v:
mSystems, Vol 2, Iss 5 (2017)
ABSTRACT Colorectal cancer (CRC) is one of the most treatable cancers, with a 5-year survival rate of ~64%, yet over 50,000 deaths occur yearly in the United States. In 15% of cases, deficiency in mismatch repair leads to null mutations in transformi
Externí odkaz:
https://doaj.org/article/a5afe66dbbc845e3873a8028da059b02
Autor:
Daniel Laubitz, Christy A Harrison, Monica T Midura-Kiela, Rajalakshmy Ramalingam, Claire B Larmonier, John H Chase, J Gregory Caporaso, David G Besselsen, Fayez K Ghishan, Pawel R Kiela
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152044 (2016)
Inflammatory bowel diseases (IBD) are associated with functional inhibition of epithelial Na+/H+ exchange. In mice, a selective disruption of NHE3 (Slc9a3), a major apical Na+/H+ exchanger, also promotes IBD-like symptoms and gut microbial dysbiosis.
Externí odkaz:
https://doaj.org/article/28718da128c4495d846ae57976e9def3