Zobrazeno 1 - 10
of 444
pro vyhledávání: '"David G Watson"'
Autor:
Gareth D Westrop, Lijie Wang, Gavin J Blackburn, Tong Zhang, Liang Zheng, David G Watson, Graham H Coombs
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189072 (2017)
Trichomonas vaginalis and Tritrichomonas foetus are pathogens that parasitise, respectively, human and bovine urogenital tracts causing disease. Using LC-MS, reference metabolomic profiles were obtained for both species and stable isotope labelling w
Externí odkaz:
https://doaj.org/article/82ad25d435ed4a0bb014aa817adaea9d
Autor:
Weam Siheri, Tong Zhang, Godwin Unekwuojo Ebiloma, Marco Biddau, Nicola Woods, Muattaz Yassein Hussain, Carol J Clements, James Fearnley, RuAngelie Edrada Ebel, Timothy Paget, Sylke Muller, Katharine C Carter, Valerie A Ferro, Harry P De Koning, David G Watson
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155355 (2016)
Extracts from twelve samples of propolis collected from different regions of Libya were tested for their activity against Trypanosoma brucei, Leishmania donovani, Plasmodium falciparum, Crithidia fasciculata and Mycobacterium marinum and the cytotoxi
Externí odkaz:
https://doaj.org/article/080c68b35d654766bdc136455b64ef0d
Autor:
Darren J Creek, Muriel Mazet, Fiona Achcar, Jana Anderson, Dong-Hyun Kim, Ruwida Kamour, Pauline Morand, Yoann Millerioux, Marc Biran, Eduard J Kerkhoven, Achuthanunni Chokkathukalam, Stefan K Weidt, Karl E V Burgess, Rainer Breitling, David G Watson, Frédéric Bringaud, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004689 (2015)
Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose e
Externí odkaz:
https://doaj.org/article/6f5a415b91f34ce6b29b7e4fca138d7b
Autor:
Gareth D Westrop, Roderick A M Williams, Lijie Wang, Tong Zhang, David G Watson, Ana Marta Silva, Graham H Coombs
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136891 (2015)
Comparative genomic analyses of Leishmania species have revealed relatively minor heterogeneity amongst recognised housekeeping genes and yet the species cause distinct infections and pathogenesis in their mammalian hosts. To gain greater information
Externí odkaz:
https://doaj.org/article/04e88e58662649bfa6f2649a6e1cf7d0
Autor:
Tong Zhang, Rong Zhang, Liang Zhang, Zhihe Zhang, Rong Hou, Hairui Wang, I Kati Loeffler, David G Watson, Malcolm W Kennedy
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143417 (2015)
Ursids (bears) in general, and giant pandas in particular, are highly altricial at birth. The components of bear milks and their changes with time may be uniquely adapted to nourish relatively immature neonates, protect them from pathogens, and suppo
Externí odkaz:
https://doaj.org/article/a831e75752184e5398b0c66c9cbb251a
Autor:
Janet Storm, Sonal Sethia, Gavin J Blackburn, Achuthanunni Chokkathukalam, David G Watson, Rainer Breitling, Graham H Coombs, Sylke Müller
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003876 (2014)
Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(
Externí odkaz:
https://doaj.org/article/d2a64c2bb86a48999a10a5353d42d4ef
Autor:
Tong Zhang, David G Watson, Lijie Wang, Muhammad Abbas, Laura Murdoch, Lisa Bashford, Imran Ahmad, Nga-Yee Lam, Anthony C F Ng, Hing Y Leung
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65880 (2013)
Human exhibit wide variations in their metabolic profiles because of differences in genetic factors, diet and lifestyle. Therefore in order to detect metabolic differences between individuals robust analytical methods are required. A protocol was pro
Externí odkaz:
https://doaj.org/article/5267bc25f0944c1b9da6b7f3cb7d91c8
Autor:
David G Watson
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 4, Iss 5, p e201301005 (2013)
Compound identification in mass spectrometry based metabolomics can be a problem but sometimes the problem seems to be presented in an over complicated way. The current review focuses on metazoans where the range of metabolites is more restricted tha
Externí odkaz:
https://doaj.org/article/1508ce2beadd4d50b5efa429ee948d85
Autor:
Venkateswara R Chintapalli, Mohammed Al Bratty, Dominika Korzekwa, David G Watson, Julian A T Dow
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78066 (2013)
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues. Comprehensive metabolite profiles for ten tissues f
Externí odkaz:
https://doaj.org/article/c573b3700d164b68bb05c30787b148ee
Autor:
Venkateswara R Chintapalli, Selim Terhzaz, Jing Wang, Mohammed Al Bratty, David G Watson, Pawel Herzyk, Shireen A Davies, Julian A T Dow
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e32577 (2012)
BACKGROUND:In humans and other animals, the internal organs are positioned asymmetrically in the body cavity, and disruption of this body plan can be fatal in humans. The mechanisms by which internal asymmetry are established are presently the subjec
Externí odkaz:
https://doaj.org/article/d381d74a09a54e798a8729ebc2281f92