Zobrazeno 1 - 10
of 204
pro vyhledávání: '"David G Strauss"'
Autor:
Christopher R Ellis, Rebecca Racz, Naomi L Kruhlak, Marlene T Kim, Alexey V Zakharov, Noel Southall, Edward G Hawkins, Keith Burkhart, David G Strauss, Lidiya Stavitskaya
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229646 (2020)
Kratom is a botanical substance that is marketed and promoted in the US for pharmaceutical opioid indications despite having no US Food and Drug Administration approved uses. Kratom contains over forty alkaloids including two partial agonists at the
Externí odkaz:
https://doaj.org/article/a24feac975674604922bfa76f58965bb
Autor:
Phu N Tran, Jiansong Sheng, Aaron L Randolph, Claudia Alvarez Baron, Nicolas Thiebaud, Ming Ren, Min Wu, Lars Johannesen, Donna A Volpe, Dakshesh Patel, Ksenia Blinova, David G Strauss, Wendy W Wu
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241362 (2020)
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTC prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transd
Externí odkaz:
https://doaj.org/article/bc6642b0a596431cad433e68b1c4b7cd
Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.
Autor:
Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W Mason, Philip T Sager, Esther Pueyo, David G Strauss
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197952 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0163619.].
Externí odkaz:
https://doaj.org/article/989426972b544a98bcaf026c2ec3d4cc
Autor:
Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W Mason, Philip T Sager, Esther Pueyo, David G Strauss
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0163619 (2016)
Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranola
Externí odkaz:
https://doaj.org/article/fc0f1c6356e94f23ac01ff3231f2fc02
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166925 (2016)
Prolongation of the heart rate corrected QT (QTc) interval is a sensitive marker of torsade de pointes risk; however it is not specific as QTc prolonging drugs that block inward currents are often not associated with torsade. Recent work demonstrated
Externí odkaz:
https://doaj.org/article/826d341666a3403aa62d8b7c1f938e41
Autor:
David G Strauss, Douglas Schocken
Providing a solid foundation in current ECG technology as well as the newest diagnostic applications, Marriott's Practical Electrocardiography, Thirteenth Edition, delivers the information you need to quickly improve your ECG interpretive skills.
Autor:
Ayesha Arefin, Melissa Mendoza, Keri Dame, M. Iveth Garcia, David G. Strauss, Alexandre J. S. Ribeiro
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Engineered heart tissues (EHTs) are three-dimensional culture platforms with cardiomyocytes differentiated from human pluripotent stem cells (hPSCs) and were designed for assaying cardiac contractility. For drug development applications
Externí odkaz:
https://doaj.org/article/0caa3dcb1e3c4d56b6be5325f29875c7
Autor:
Kimberly Chiu, Rebecca Racz, Keith Burkhart, Jeffry Florian, Kevin Ford, M. Iveth Garcia, Robert M. Geiger, Kristina E. Howard, Paula L. Hyland, Omnia A. Ismaiel, Naomi L. Kruhlak, Zhihua Li, Murali K. Matta, Kristin W. Prentice, Aanchal Shah, Lidiya Stavitskaya, Donna A. Volpe, James L. Weaver, Wendy W. Wu, Rodney Rouse, David G. Strauss
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
The U.S. Food and Drug Administration (FDA) Division of Applied Regulatory Science (DARS) moves new science into the drug review process and addresses emergent regulatory and public health questions for the Agency. By forming interdisciplinary teams,
Externí odkaz:
https://doaj.org/article/9d617856bbe343189c0a88673db07198
Autor:
Ksenia Blinova, Derek Schocken, Dakshesh Patel, Chathuri Daluwatte, Jose Vicente, Joseph C. Wu, David G. Strauss
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 687-697 (2019)
Induced pluripotent stem cells (iPSCs) have shown promise in investigating donor‐specific phenotypes and pathologies. The iPSC‐derived cardiomyocytes (iPSC‐CMs) could potentially be utilized in personalized cardiotoxicity studies, assessing ind
Externí odkaz:
https://doaj.org/article/2ea84baf81e3442e8d5d12af4422e345
Autor:
Ryan De Palma, Vikram Patel, Jeffry Florian, David Keire, Daniela Selaya, David G. Strauss, Rodney Rouse, Murali K. Matta
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1315-1323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3496fadd67e747e2092c9f429406ff
https://doi.org/10.1016/j.xphs.2023.01.026
https://doi.org/10.1016/j.xphs.2023.01.026