Zobrazeno 1 - 10
of 52
pro vyhledávání: '"David G Skalnik"'
Autor:
Kristin T Chun, Binghui Li, Erika Dobrota, Courtney Tate, Jeong-Heon Lee, Shehnaz Khan, Laura Haneline, Harm HogenEsch, David G Skalnik
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113745 (2014)
CXXC finger protein 1 (Cfp1), encoded by the Cxxc1 gene, binds to DNA sequences containing an unmethylated CpG dinucleotide and is an epigenetic regulator of both cytosine and histone methylation. Cxxc1-null mouse embryos fail to gastrulate, and Cxxc
Externí odkaz:
https://doaj.org/article/bc19738d5e6d4473b7bac445f44b5df8
Autor:
Jeong-Heon Lee, David G Skalnik
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42965 (2012)
The Rbm15-Mkl1 fusion protein is associated with acute megakaryoblastic leukemia (AMKL), although little is known regarding the molecular mechanism(s) whereby this fusion protein contributes to leukemogenesis. Here, we show that both Rbm15 and the le
Externí odkaz:
https://doaj.org/article/5908ef7e87f94deebe9038472bf7a715
Autor:
Seung Chel Yang, Mira Park, Kwon-Ho Hong, Hyeonwoo La, Chanhyeok Park, Peike Wang, Gaizhen Li, Qionghua Chen, Youngsok Choi, Francesco J. DeMayo, John P. Lydon, David G. Skalnik, Hyunjung J. Lim, Seok-Ho Hong, So Hee Park, Yeon Sun Kim, Hye-Ryun Kim, Haengseok Song
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the und
Externí odkaz:
https://doaj.org/article/6444b23feea846438ea6b8cd5143100b
Autor:
Kenneth P. Nephew, Tim H-M. Huang, David G. Skalnik, Suzanne Young, Teresa Craft, Pearlly Yan, Curtis Balch
Supplemental Data from Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa02c3d30aa241ed89ce6821d0406ec
https://doi.org/10.1158/1535-7163.22484618
https://doi.org/10.1158/1535-7163.22484618
Autor:
Kenneth P. Nephew, Tim H-M. Huang, David G. Skalnik, Suzanne Young, Teresa Craft, Pearlly Yan, Curtis Balch
Deoxycytosine methylation within CpG islands of tumor suppressor genes plays a prominent role in the development and progression of drug-resistant ovarian cancer. Consequently, epigenetic therapies directed toward tumor suppressor demethylation/reexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398ecdcbd5e55736c25a10fe4a946a2e
https://doi.org/10.1158/1535-7163.c.6531491.v1
https://doi.org/10.1158/1535-7163.c.6531491.v1
Autor:
Kwangbeom Hyun, Kai Ge, Kihyun Park, David G. Skalnik, Jae-Hoon Kim, Jeong Heon Lee, Linjiao Zhou, Tom W. Muir, Young Wook Cho, Min-Jung Kwon
Publikováno v:
Nucleic Acids Research
In mammalian cells, distinct H3K4 methylation states are created by deposition of methyl groups by multiple complexes of histone lysine methyltransferase 2 (KMT2) family proteins. For comprehensive analyses that directly compare the catalytic propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8ed7d95db0dc2280a9b45401c4d709
https://doi.org/10.1093/nar/gkaa317
https://doi.org/10.1093/nar/gkaa317
Autor:
Byeong Seong Ki, Sung Han Shim, Chanhyeok Park, Hyunjin Yoo, Hyeonwoo La, Ok-Hee Lee, Youngjoo Kwon, David G. Skalnik, Yuki Okada, Ho-Geun Yoon, Jin-Hoi Kim, Kwonho Hong, Youngsok Choi
Publikováno v:
Experimentalmolecular medicine. 54(8)
Meiosis occurs specifically in germ cells to produce sperm and oocytes that are competent for sexual reproduction. Multiple factors are required for successful meiotic entry, progression, and termination. Among them, trimethylation of histone H3 on l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea1ea58e919f3bd79e3148416de1348
https://pubmed.ncbi.nlm.nih.gov/35918532
https://pubmed.ncbi.nlm.nih.gov/35918532
Autor:
Jeong-Heon Lee, David G. Skalnik
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a408481e80c5aaf1f4347bd590ee2ee
https://doi.org/10.1016/b978-0-12-819460-7.00213-9
https://doi.org/10.1016/b978-0-12-819460-7.00213-9
Autor:
David G. Skalnik, Jyothi Mahadevan
Publikováno v:
Gene. 594:1-9
Mammalian CXXC finger protein 1 (Cfp1) is a DNA-binding protein that is a component of the Setd1 histone methyltransferase complexes and is a critical epigenetic regulator of both histone and cytosine methylation. Murine embryonic stem (ES) cells lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ab19a4d097aaaa1dff320f4b440ea9
https://doi.org/10.1016/j.gene.2016.08.048
https://doi.org/10.1016/j.gene.2016.08.048
Autor:
Xueling Jin, Jun Zhang, Jiwen Li, David G. Skalnik, Xingxu Huang, Jiemin Wong, Yong Zhang, Hui Zhang, Ling Zhang, Lan Fang, Xiaoqin Yang, Ying Jin
Publikováno v:
Stem Cells. 34:565-580
Limited core transcription factors and transcriptional cofactors have been shown to govern embryonic stem cell (ESC) transcriptional circuitry and pluripotency, but the molecular interactions between the core transcription factors and cofactors remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8723055c2e55efb1de5eed073e7cc0c2
https://doi.org/10.1002/stem.2250
https://doi.org/10.1002/stem.2250