Zobrazeno 1 - 10
of 283
pro vyhledávání: '"David G Little"'
Autor:
Alexandra K O'Donohue, Xiaoying C Li, Lucinda R Lee, Emily R Vasiljevski, David G Little, Craig F Munns, Aaron Schindeler
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304778 (2024)
Neurofibromatosis type 1 (NF1) is a complex genetic disorder that affects a range of tissues including muscle and bone. Recent preclinical and clinical studies have shown that Nf1 deficiency in muscle causes metabolic changes resulting in intramyocel
Externí odkaz:
https://doaj.org/article/6d3c585f80ff4578b890f9ac07be828e
Autor:
Emily R Vasiljevski, Peter J Houweling, Thusitha Rupasinghe, Tarneet Kaur, Matthew A Summers, Ute Roessner, David G Little, Aaron Schindeler
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237097 (2020)
Neurofibromatosis type 1 (NF1) is a genetic disorder that affects a range of tissue systems, however the associated muscle weakness and fatigability can have a profound impact on quality of life. Prior studies using the limb-specific Nf1 knockout mou
Externí odkaz:
https://doaj.org/article/f67afae36e68477c980073e0096474ba
Autor:
Tegan L Cheng, Ciara M Murphy, Roya Ravarian, Fariba Dehghani, David G Little, Aaron Schindeler
Publikováno v:
Journal of Tissue Engineering, Vol 6 (2015)
Sucrose acetate isobutyrate (SAIB) is a sugar-based carrier. We have previously applied SAIB as a minimally invasive system for the co-delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) and found synergy when co-delivering zoledroni
Externí odkaz:
https://doaj.org/article/240dd5f7b0704a87817c5482d7d46cce
Autor:
Dana M Cairns, Renjing Liu, Manpreet Sen, James P Canner, Aaron Schindeler, David G Little, Li Zeng
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39642 (2012)
Muscle satellite cells make up a stem cell population that is capable of differentiating into myocytes and contributing to muscle regeneration upon injury. In this work we investigate the mechanism by which these muscle progenitor cells adopt an alte
Externí odkaz:
https://doaj.org/article/9c545f8705834991a779552ae66097e6
Autor:
Paul A Baldock, Nicola J Lee, Frank Driessler, Shu Lin, Susan Allison, Bernhard Stehrer, En-Ju D Lin, Lei Zhang, Ronald F Enriquez, Iris P L Wong, Michelle M McDonald, Matthew During, Dominique D Pierroz, Katy Slack, Yan C Shi, Ernie Yulyaningsih, Aygul Aljanova, David G Little, Serge L Ferrari, Amanda Sainsbury, John A Eisman, Herbert Herzog
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8415 (2009)
Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status.
Externí odkaz:
https://doaj.org/article/1c4e10f85e774d4ab672cfe858d76d32
Autor:
Aiken Dao, Alexandra K. O'Donohue, Emily R. Vasiljevski, Justin D. Bobyn, David G. Little, Aaron Schindeler
Publikováno v:
Journal of Bone and Joint Infection. 8:81-89
Introduction: Osteomyelitis remains a major clinical challenge. Many published rodent fracture infection models are costly compared with murine models for rapid screening and proof-of-concept studies. We aimed to develop a dependable and cost-effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0bbcc30dcfb92d6f96134a8a6005d5
https://doi.org/10.5194/jbji-8-81-2023
https://doi.org/10.5194/jbji-8-81-2023
Autor:
Alexandra K. O'Donohue, Aiken Dao, Justin D. Bobyn, Craig F. Munns, David G. Little, Aaron Schindeler
Publikováno v:
Journal of Orthopaedic Research. 41:808-814
Osteogenesis imperfecta (OI) is a genetic bone fragility disorder that features frequent fractures. Bone healing outcomes are contingent on a proper balance between bone formation and resorption, and drugs such as bone morphogenetic proteins (BMPs) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a281dce21b425e1ca0c9ede462c7d3fb
https://doi.org/10.1002/jor.25414
https://doi.org/10.1002/jor.25414
Publikováno v:
Journal of Pediatric Orthopaedics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56ce77f75aea9e0a07e4ab13f0766ec
https://doi.org/10.1097/bpo.0000000000002407
https://doi.org/10.1097/bpo.0000000000002407
Publikováno v:
Journal of Children's Orthopaedics
Purpose The modified Dunn procedure for slipped capital femoral epiphysis (SCFE) remains controversial. We reviewed our series over ten years to report our learning curve, experience with intraoperative monitoring of femoral head perfusion and its co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcb6a35ddd2d7389616a9a9fe30283b
https://doi.org/10.1302/1863-2548.15.210106
https://doi.org/10.1302/1863-2548.15.210106
Autor:
Colin R. Dunstan, Aaron Schindeler, David G. Little, Aiken Dao, Hala Zreiqat, Mohammad Mirkhalaf
Publikováno v:
Acta Biomaterialia. 132:217-226
An ongoing challenge in the field of orthopedics is to produce a clinically relevant synthetic ceramic scaffold for the treatment of ‘critical-sized’ bone defects, which cannot heal without intervention. We had developed a bioactive ceramic (bagh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f087d81c87cd371dd5b53cbb34e8ca
https://doi.org/10.1016/j.actbio.2021.03.012
https://doi.org/10.1016/j.actbio.2021.03.012