Zobrazeno 1 - 10
of 338
pro vyhledávání: '"David G Lambert"'
Autor:
Marianna Danielli, Roisin C Thomas, Clare L Gillies, David G Lambert, Kamlesh Khunti, Bee Kang Tan
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0284412 (2023)
BackgroundVascular adhesion protein 1 (VAP-1) has been implicated in a wide range of clinical conditions. Moreover, serum levels are associated with disease prediction and progression in several clinical studies. There is a paucity of data on VAP-1 a
Externí odkaz:
https://doaj.org/article/fa23a3e2d9f34e9ca61f4a63a3a1ce6f
Autor:
Mark F Bird, Barbara Gallacher-Horley, John McDonald, David G McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, Jonathan P Thompson, David G Lambert
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274080 (2022)
Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cell
Externí odkaz:
https://doaj.org/article/728521bbead94fd4a165d745c4891b04
Autor:
Despina Giakomidi, Mark F Bird, John McDonald, Erika Marzola, Remo Guerrini, Serena Chanoch, Nidhuna Sabu, Barbara Horley, Girolamo Calo, David G Lambert
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250011 (2021)
The μ-opioid peptide (MOP) receptor is a member of the opioid receptor family and an important clinical target for analgesia. Measuring MOP receptor location and tracking its turnover traditionally used radiolabels or antibodies with attendant probl
Externí odkaz:
https://doaj.org/article/3d721b91f5e747c9a50308c7c9d303cf
Autor:
Mark F Bird, Maria Camilla Cerlesi, Mark Brown, Davide Malfacini, Vanessa Vezzi, Paola Molinari, Laura Micheli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Remo Guerrini, Girolamo Calò, David G Lambert
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156897 (2016)
INTRODUCTION:Opioid receptors are currently classified as Mu (μ), Delta (δ), Kappa (κ) plus the opioid related nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP). Despite compelling evidence for interactions and benefits of targeting more than
Externí odkaz:
https://doaj.org/article/3092637ca6544ce6a59e3d0542cdba8b
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Properdin is a normal serum protein which increases the production of complement activation products by binding to C3b integral to convertase complexes and amplifying their activity at the site of activation. Thereby, it can aid in the resolution of
Externí odkaz:
https://doaj.org/article/fc670a6858e74f2598eb5cbdc85d6477
Autor:
Zoë L S Brookes, Emily N Stedman, Nicola J Brown, Christopher P Hebbes, Remo Guerrini, Girolamo Calo, Charles S Reilly, David G Lambert
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74943 (2013)
Microvascular inflammation occurs during sepsis and the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) is known to regulate inflammation. This study aimed to determine the inflammatory role of N/OFQ and its receptor NOP (ORL1) within t
Externí odkaz:
https://doaj.org/article/3e7a56646f904c4a90c62a4b19a28542
Autor:
Jonathan P Thompson, Alcira Serrano-Gomez, John McDonald, Nadia Ladak, Sarah Bowrey, David G Lambert
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76682 (2013)
BACKGROUND AND OBJECTIVES:Nociceptin/Orphanin FQ (N/OFQ) is a non-classical endogenous opioid peptide that modulates immune function in vitro. Its importance in inflammation and human sepsis is unknown. The objectives of this study were to determine
Externí odkaz:
https://doaj.org/article/bbd0d78cdc5a47e089e5aa7e5df1e0d6
Publikováno v:
BJA Open, Vol 2, Iss , Pp 100010- (2022)
There is a controversial narrative in the anaesthetic literature suggesting that anaesthetic technique (including opioids) may be detrimental to survival after tumour resection. The initial observations were retrospective. Several prospective studies
Externí odkaz:
https://doaj.org/article/009c367cf2f14379aeae7c228d253259
Autor:
David J. Webb, Hubert Vaudry, David Vaudry, Hervé Tostivint, Walter G. Thomas, Eliot H. Ohlstein, Margaret R. MacLean, Jérôme Leprince, David G. Lambert, Henry Krum, Adel Giaid, Alain Fournier, Stephen A. Douglas, Anthony P. Davenport
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The urotensin-II (U-II) receptor (UT, nomenclature as agreed by the NC-IUPHAR Subcommittee on the Urotensin receptor [26, 36, 94]) is activated by the endogenous dodecapeptide urotensin-II, originally isolated from the urophysis, the endocrine organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f638e317c41a14a4e5e896c0fcde699b
https://doi.org/10.2218/gtopdb/f65/2023.1
https://doi.org/10.2218/gtopdb/f65/2023.1
Autor:
Mark F. Bird, Christopher P. Hebbes, Anushuya Tamang, Jonathon Mark Willets, Jonathan P. Thompson, Remo Guerrini, Girolamo Calo, David G. Lambert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316f1aec76a8fa1c191adf9c25cbd62
https://hdl.handle.net/11577/3479489
https://hdl.handle.net/11577/3479489
