Výsledky vyhledávání - "David G Lambert"

Akademický článek

Opioids and opioid receptors; understanding pharmacological mechanisms as a key to therapeutic advances and mitigation of the misuse crisis

Autor: David G. Lambert

Publikováno v: BJA Open, Vol 6, Iss , Pp 100141- (2023)

Opioids are a mainstay in acute pain management and produce their effects and side effects (e.g., tolerance, opioid-use disorder and immune suppression) by interaction with opioid receptors. I will discuss opioid pharmacology in some controversial ar

Externí odkaz: https://doaj.org/article/04af500ec2944e7489531c54fff9b776

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Akademický článek

Soluble Vascular Adhesion Protein 1 (sVAP-1) as a biomarker for pregnancy complications: A pilot study.

Autor: Marianna Danielli, Roisin C Thomas, Clare L Gillies, David G Lambert, Kamlesh Khunti, Bee Kang Tan

Publikováno v: PLoS ONE, Vol 18, Iss 5, p e0284412 (2023)

BackgroundVascular adhesion protein 1 (VAP-1) has been implicated in a wide range of clinical conditions. Moreover, serum levels are associated with disease prediction and progression in several clinical studies. There is a paucity of data on VAP-1 a

Externí odkaz: https://doaj.org/article/fa23a3e2d9f34e9ca61f4a63a3a1ce6f

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Akademický článek

Nociceptin/Orphanin FQ receptor expression in primary human umbilical vein endothelial cells is not regulated by exposure to breast cancer cell media or angiogenic stimuli

Autor: Despina Giakomidi, Sonja Khemiri, Wadhah Mahbuba, David G. McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, David G. Lambert

Publikováno v: BJA Open, Vol 4, Iss , Pp 100110- (2022)

Background: Opioid receptors are naloxone-sensitive (MOP [mu: μ], DOP [delta: δ], and KOP [kappa: κ]) and naloxone-insensitive Nociceptin/Orphanin FQ (N/OFQ) peptide receptor (NOP). Clinically, most opioid analgesics target MOP. Angiogenesis is th

Externí odkaz: https://doaj.org/article/1dee7627c7d04f38879e5822c85bdbf7

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Akademický článek

Opioids and cancer survival: are we looking in the wrong place?

Autor: Despina Giakomidi, Mark F. Bird, David G. Lambert

Publikováno v: BJA Open, Vol 2, Iss , Pp 100010- (2022)

There is a controversial narrative in the anaesthetic literature suggesting that anaesthetic technique (including opioids) may be detrimental to survival after tumour resection. The initial observations were retrospective. Several prospective studies

Externí odkaz: https://doaj.org/article/009c367cf2f14379aeae7c228d253259

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Akademický článek

In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells

Autor: Mark F. Bird, Barbara Gallacher-Horley, John McDonald, David G. McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, Jonathan P. Thompson, David G. Lambert

Publikováno v: PLoS ONE, Vol 17, Iss 9 (2022)

Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cell

Externí odkaz: https://doaj.org/article/9c6ee19a704e489aa1cb76aea8f0b547

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Akademický článek

Evaluation of [Cys(ATTO 488)8]Dermorphin-NH2 as a novel tool for the study of μ-opioid peptide receptors.

Autor: Despina Giakomidi, Mark F Bird, John McDonald, Erika Marzola, Remo Guerrini, Serena Chanoch, Nidhuna Sabu, Barbara Horley, Girolamo Calo, David G Lambert

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0250011 (2021)

The μ-opioid peptide (MOP) receptor is a member of the opioid receptor family and an important clinical target for analgesia. Measuring MOP receptor location and tracking its turnover traditionally used radiolabels or antibodies with attendant probl

Externí odkaz: https://doaj.org/article/3d721b91f5e747c9a50308c7c9d303cf

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