Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David G Belair"'
Autor:
David G Belair, Cynthia J Wolf, Carmen Wood, Hongzu Ren, Rachel Grindstaff, William Padgett, Adam Swank, Denise MacMillan, Anna Fisher, Witold Winnik, Barbara D Abbott
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184155 (2017)
Epithelial-mesenchymal interactions drive embryonic fusion events during development, and perturbations of these interactions can result in birth defects. Cleft palate and neural tube defects can result from genetic defects or environmental exposures
Externí odkaz:
https://doaj.org/article/7bb9513a655245f09dd7080fa08081bf
Publikováno v:
Biomater Sci
Prolonged and elevated transforming growth factor-β1 (TGF-β1) signaling can lead to undesired scar formation during tissue repair and fibrosis that is often a result of chronic inflammation in the lung, kidney, liver, heart, skin, and joints. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70dc0fcef54f6bae9c9ac7367556364d
https://doi.org/10.1039/d0bm01374a
https://doi.org/10.1039/d0bm01374a
Autor:
Barbara D. Abbott, David G. Belair, Nisha S. Sipes, Nancy C. Baker, Thomas B. Knudsen, Richard S. Judson, Jill A Franzosa
Publikováno v:
Birth Defects Res
Cleft palate has been linked to both genetic and environmental factors that perturb key events during palatal morphogenesis. As a developmental outcome, it presents a challenging, mechanistically complex endpoint for predictive modeling. A data set o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a66a6629ca1957bb977fe961e5aeff7
https://doi.org/10.1002/bdr2.1581
https://doi.org/10.1002/bdr2.1581
Autor:
Deidre A. Dalmas, Saket Agarwal, Simone H. Stahl, Diane Ramsden, Sara C. Humphreys, Patrik U. Andersson, David G. Belair, Chris Maclauchlin, Joseph A Cichocki
Publikováno v:
ALTEX.
Oligonucleotide therapeutics (ONTs) encompass classes of medicines that selectively target and potentially ameliorate previously untreatable and often rare diseases. Several unique classes of ONTs provide versatility, enabling direct modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96765263dfdfe7142ac577a2ea69e4a
https://doi.org/10.14573/altex.2108241
https://doi.org/10.14573/altex.2108241
Autor:
Kyle L. Kolaja, David G. Belair, Richard J. Visconti, Miyoun Hong, Matthew F. Peters, Mathieu Marella, Clay W Scott
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 68
Drug-induced gastrointestinal toxicity (GIT) is a common treatment-emergent adverse event that can negatively impact dosing, thereby limiting efficacy and treatment options for patients. An in vitro assay of GIT is needed to address patient variabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d336e69f38cba673b293ecdee817bbc
https://pubmed.ncbi.nlm.nih.gov/32622998
https://pubmed.ncbi.nlm.nih.gov/32622998
Autor:
Laura E. Waller, Jason A. Gustin, David G. Belair, Gang Lu, Kyle L. Kolaja, Nathaniel D. Collins
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Exposure to thalidomide during a critical window of development results in limb defects in humans and non-human primates while mice and rats are refractory to these effects. Thalidomide-induced teratogenicity is dependent on its binding to cereblon (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e460682687fc664188fb090bf27b48
https://doi.org/10.1038/s41598-020-59542-x
https://doi.org/10.1038/s41598-020-59542-x
Autor:
Shoujian Wang, Nader Sheibani, Michael J. Miller, David G. Belair, Bernard Y. K. Binder, Soesiawati R. Darjatmoko, William L. Murphy
Publikováno v:
Biomaterials. 93:27-37
Vascular endothelial growth factor (VEGF) spatial and temporal activity must be tightly controlled during angiogenesis to form perfusable vasculature in a healing wound. The native extracellular matrix (ECM) regulates growth factor activity locally v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a66d97ce544cb055ec5ff50ed97a46
https://doi.org/10.1016/j.biomaterials.2016.03.021
https://doi.org/10.1016/j.biomaterials.2016.03.021
Publikováno v:
Acta Biomaterialia. 39:12-24
Activation of vascular endothelial cells (ECs) by growth factors initiates a cascade of events during angiogenesis in vivo consisting of EC tip cell selection, sprout formation, EC stalk cell proliferation, and ultimately vascular stabilization by su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8220c185d63a57333c845f49ba4b3242
https://doi.org/10.1016/j.actbio.2016.05.020
https://doi.org/10.1016/j.actbio.2016.05.020
Autor:
Carmen R. Wood, Sierra D Moorefield, Carrie M. Becker, Cynthia J. Wolf, David G. Belair, Barbara D. Abbott
Publikováno v:
Toxicological Sciences.
Embryologic development involves cell differentiation and organization events that are unique to each tissue and organ and are susceptible to developmental toxicants. Animal models are the gold standard for identifying putative teratogens, but the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3548350fdebcbe27fffed0fe1a963bd5
https://doi.org/10.1093/toxsci/kfy207
https://doi.org/10.1093/toxsci/kfy207
Autor:
David G. Belair, Barbara D. Abbott, Judith E. Schmid, Carrie M. Becker, Cynthia J. Wolf, Kaberi P. Das
Publikováno v:
Birth defects research. 110(17)
Background Cleft palate (CP) is a common birth defect, occurring in an estimated 1 in 1,000 births worldwide. The secondary palate is formed by paired palatal shelves, consisting of a mesenchymal core with an outer layer of epithelial cells that grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f4211f593ec84a2fdcdc0bb0b2d954
https://pubmed.ncbi.nlm.nih.gov/30347137
https://pubmed.ncbi.nlm.nih.gov/30347137