Zobrazeno 1 - 10
of 573
pro vyhledávání: '"David G, Standaert"'
Autor:
Huixian Hong, Yong Wang, Marissa Menard, Jessica A. Buckley, Lianna Zhou, Laura Volpicelli-Daley, David G. Standaert, Hongwei Qin, Etty N. Benveniste
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Parkinson’s disease (PD) is characterized by neuroinflammation, progressive loss of dopaminergic neurons, and accumulation of α-synuclein (α-Syn) into insoluble aggregates called Lewy pathology. The Line 61 α-Syn mouse is an established
Externí odkaz:
https://doaj.org/article/2b84aadb4e09490db4dee86d56fe683b
Autor:
Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn Erb, Darren J. Moore, Laurie H. Sanders, Michael W. Lutz, Dmitry Velmeshev, Andrew B. West
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)
Abstract Background LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson’s disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of i
Externí odkaz:
https://doaj.org/article/cbe5ed539df9444082143ccaca2754bf
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106685- (2024)
Altered interaction between striatonigral dopaminergic (DA) inputs and local acetylcholine (ACh) in striatum has long been hypothesized to play a central role in the pathophysiology of dystonia and dyskinesia. Indeed, previous research using several
Externí odkaz:
https://doaj.org/article/013e0f47b7474a4c9ed541cb928f9ac1
Autor:
Haydeh Payami, Gwendolyn Cohen, Charles F. Murchison, Timothy R. Sampson, David G. Standaert, Zachary D. Wallen
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-5 (2023)
Abstract Parkinson’s disease is the fastest-growing neurologic disease with seemingly no means of prevention. Intrinsic risk factors (age, sex, and genetics) are inescapable, but environmental factors are not. We identified repeated blows to the he
Externí odkaz:
https://doaj.org/article/9c8d1762417746bdbf7d1ad5f08d965c
Autor:
Jason Aldred, Eric Freire-Alvarez, Alexander V. Amelin, Angelo Antonini, Bruno Bergmans, Filip Bergquist, Manon Bouchard, Kumar Budur, Camille Carroll, K. Ray Chaudhuri, Susan R. Criswell, Erik H. Danielsen, Florin Gandor, Jia Jia, Thomas E. Kimber, Hideki Mochizuki, Weining Z. Robieson, Amy M. Spiegel, David G. Standaert, Saritha Talapala, Maurizio F. Facheris, Victor S. C. Fung
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1937-1958 (2023)
Abstract Introduction Foslevodopa/foscarbidopa, a soluble formulation of levodopa/carbidopa (LD/CD) prodrugs for the treatment of Parkinson’s disease (PD), is administered as a 24-hour/day continuous subcutaneous infusion (CSCI) with a single infus
Externí odkaz:
https://doaj.org/article/3c28527413ce4845845ba7b0a3dbeb25
Publikováno v:
Dystonia, Vol 2 (2023)
Dystonia refers to a heterogeneous group of movement disorders characterized by involuntary, sustained muscle contractions leading to repetitive twisting movements and abnormal postures. Dystonia has a broad clinical spectrum and can affect different
Externí odkaz:
https://doaj.org/article/7e024c412b224672b439a8a0c9d872fc
Autor:
Zachary D. Wallen, Ayse Demirkan, Guy Twa, Gwendolyn Cohen, Marissa N. Dean, David G. Standaert, Timothy R. Sampson, Haydeh Payami
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Here, the authors perform large-scale high-resolution Parkinson’s disease metagenomics analyses, revealing widespread dysbiosis characterized by overabundance of pathogens, immunogens, toxicants, and curli, reduction in neuroprotective and antiinfl
Externí odkaz:
https://doaj.org/article/36926e90f9f04cf1aa145085ad06354e
Autor:
Jason Aldred, Eric Freire-Alvarez, Alexander V. Amelin, Angelo Antonini, Bruno Bergmans, Filip Bergquist, Manon Bouchard, Kumar Budur, Camille Carroll, K. Ray Chaudhuri, Susan R. Criswell, Erik H. Danielsen, Florin Gandor, Jia Jia, Thomas E. Kimber, Hideki Mochizuki, Weining Z. Robieson, Amy M. Spiegel, David G. Standaert, Saritha Talapala, Maurizio F. Facheris, Victor S. C. Fung
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1959-1960 (2023)
Externí odkaz:
https://doaj.org/article/fbd221fdae034683822ddee813fd4949
Autor:
Rekha Dhanwani, João Rodrigues Lima-Junior, Ashu Sethi, John Pham, Gregory Williams, April Frazier, Yaqian Xu, Amy W. Amara, David G. Standaert, Jennifer G. Goldman, Irene Litvan, Roy N. Alcalay, Bjoern Peters, David Sulzer, Cecilia S. Lindestam Arlehamn, Alessandro Sette
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Parkinson’s disease (PD) is a multi-stage neurodegenerative disorder with largely unknown etiology. Recent findings have identified PD-associated autoimmune features including roles for T cells. To further characterize the role of T cells
Externí odkaz:
https://doaj.org/article/fb806e6ca1ad4d80bc031c69934a1768
Autor:
Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert, Andrew B. West
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-19 (2022)
Abstract Background Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression in pro-inflammat
Externí odkaz:
https://doaj.org/article/650263aba80f4a2ebcfa23775edbadc2