Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David Fusco-DeMane"'
Publikováno v:
Molecular Endocrinology. 9:1468-1476
The most important regulator of insulin expression in islet beta-cells is glucose, which stimulates insulin gene transcription, protein synthesis, and secretion. Glucose-induced insulin gene transcription is regulated by cis-acting elements found wit
Autor:
Manju Surana, Margarita Leiser, Shimon Efrat, Norman Fleischer, David Fusco-Demane, Luciano Rossetti, Ronald A. DePinho, Deeksha Bali, Harry Hou, Anton Svetlanov, Baojie Li, Nir Barzilai, Han Woong Lee
Publikováno v:
Journal of Biological Chemistry. 270:21464-21467
Glucokinase catalyzes a rate-limiting step in glucose metabolism in hepatocytes and pancreatic β cells and is considered the “glucose sensor” for regulation of insulin secretion. Patients with maturity-onset diabetes of the young (MODY) have het
Autor:
David Knaack, Deborah M. Fiore, Manju Surana, David Fusco-DeMane, Norman Fleischer, Margarita Leiser, Orion D. Hegre, Megan E. Laurance, Shimon Efrat
Publikováno v:
Diabetes. 43:1413-1417
A number of pancreatic β-tumor cell (β TC) lines have been derived from insulinomas arising in transgenic mice expressing the SV40 T antigen gene under control of the insulin promoter. Some of these lines secrete insulin in response to physiologica
Autor:
Manju Surana, Gordon C. Weir, David Fusco-Demane, Mark A. Magnuson, Shimon Efrat, Margarita Leiser, Norman Fleischer, T. L. Jetton, Ying-Jian Wu, O A Emran
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 91(6)
Phosphorylation of glucose to glucose 6-phosphate by glucokinase (GK; EC 2.7.1.2) serves as a glucose-sensing mechanism for regulating insulin secretion in beta cells. Recent findings of heterozygous GK gene mutations in patients with maturity-onset
Autor:
Shimon Efrat, Norman Fleischer, Manju Surana, Margarit Leiser, Michael Tal, David Fusco-Demane
Publikováno v:
Diabetes. 42(6)
Pancreatic beta TC lines derived from insulinomas arising in transgenic mice expressing SV40 Tag under control of the insulin promoter manifest a differentiated beta-cell phenotype and secrete insulin in response to glucose. Previously reported beta