Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David Frescas"'
Autor:
David Frescas, Evguenia Strom, Tamara Tchkonia, Valeria Kogan, Brandon M. Hall, Slavoljub Vujcic, Yi Zhu, Peter Krasnov, James L. Kirkland, Olga B. Chernova, Igor Koman, Marina P. Antoch, Andrei V. Gudkov, Olga V. Leontieva, Anatoli S. Gleiberman
Publikováno v:
Aging Cell
Adipose tissue is recognized as a major source of systemic inflammation with age, driving age‐related tissue dysfunction and pathogenesis. Macrophages (Mφ) are central to these changes yet adipose tissue Mφ (ATMs) from aged mice remain poorly cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23db66c340cf3e954a94d54922273730
http://europepmc.org/articles/PMC7576241
http://europepmc.org/articles/PMC7576241
Autor:
David Frescas, Brandon M. Hall, Slavoljub Vujcic, Lauren P. Virtuoso, Mahima Gupta, Evguenia Strom, Olga B. Chernova, Elena Rydkina, Anatoli S. Gleiberman, Vitaly Balan, Andrei V. Gudkov
Publikováno v:
Cell Cycle. 16:1526-1533
Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00069bbfd5317561dc69bf20edd2809a
https://doi.org/10.1080/15384101.2017.1339850
https://doi.org/10.1080/15384101.2017.1339850
Autor:
Michelle Wrobel, Semra Aygun-Sunar, Andrei L. Osterman, Christelle M. Roux, Anatoli S. Gleiberman, David Frescas, Marina P. Antoch, Evguenia Strom, Peter Krasnov, Olga B. Chernova, Vadim L. Mett, Andrei V. Gudkov, Oleg V. Kurnasov, Lauren P. Virtuoso
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(9)
Studying the phenomenon of cellular senescence has been hindered by the lack of senescence-specific markers. As such, detection of proteins informally associated with senescence accompanies the use of senescence-associated β-galactosidase as a colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7fb2e57ba54c957b546ae47ff9948c
https://pubmed.ncbi.nlm.nih.gov/28193858
https://pubmed.ncbi.nlm.nih.gov/28193858
Publikováno v:
Molecular Cell. 44(4):647-659
To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclusion. However, comparison of the DNA binding affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4208ef001a35b5273b02048c03f3aede
Autor:
Timothy Cardozo, Antonio Iavarone, Sandy Chang, N. Valerio Dorrello, Daniele Guardavaccaro, Eva Hernando, Michele Pagano, Anna Lasorella, Asha S. Multani, David Frescas, Angelo Peschiaroli
Publikováno v:
Nature. 452:365-369
The transcription factor REST has been implicated in tumourigenesis, and β-TrCP regulates REST degradation. REST, in turn, controls the chromosome stability by regulating the expression of spindle checkpoint protein Mad2, suggesting that this mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8b8d6580376bb57b82fb83942b5c60
https://doi.org/10.1038/nature06641
https://doi.org/10.1038/nature06641
The capability to modify the genome precisely and efficiently offers an extremely useful tool for biomedical research. Recent developments in genome editing technologies such as transcription activator-like effector nuclease and the clustered regular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1090ba389391e1bfef878ac0fa2e10f5
https://europepmc.org/articles/PMC4935289/
https://europepmc.org/articles/PMC4935289/
Publikováno v:
The Journal of Cell Biology
Drosophila melanogaster embryogenesis begins with 13 nuclear division cycles within a syncytium. This produces >6,000 nuclei that, during the next division cycle, become encased in plasma membrane in the process known as cellularization. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20daf226aa5b92c7ebf4f8a8e04e58de
https://doi.org/10.1083/jcb.200601156
https://doi.org/10.1083/jcb.200601156
Publikováno v:
Molecular Biology of the Cell. 15:4512-4521
Drosophila ovarian cysts arise through a series of four synchronous incomplete mitotic divisions. After each round of mitosis, a membranous organelle, the fusome, grows along the cleavage furrow and the remnants of the mitotic spindle to connect all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f62482abdbc26b60e675ad3660e032c
https://doi.org/10.1091/mbc.e04-06-0475
https://doi.org/10.1091/mbc.e04-06-0475
Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection
Autor:
David Frescas, Titia de Lange
Publikováno v:
The Journal of biological chemistry. 289(35)
The single-stranded DNA binding proteins in mouse shelterin, POT1a and POT1b, accumulate at telomeres as heterodimers with TPP1, which binds TIN2 and thus links the TPP1/POT1 dimers with TRF1 and TRF2/Rap1. When TPP1 is tethered to TIN2/TRF1/TRF2, PO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9fbea8d9b1c3a862bc9bc93840aad7
https://pubmed.ncbi.nlm.nih.gov/25056954
https://pubmed.ncbi.nlm.nih.gov/25056954
Autor:
David Frescas, Titia de Lange
The shelterin protein TIN2 is required for the telomeric accumulation of TPP1/POT1 heterodimers and for the protection of telomeres by the POT1 proteins (POT1a and POT1b in the mouse). TIN2 also binds to TRF1 and TRF2, improving the telomeric localiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81d64f5d5307c28c4e9d238bb57e0c5
https://europepmc.org/articles/PMC3993560/
https://europepmc.org/articles/PMC3993560/