Zobrazeno 1 - 3
of 3
pro vyhledávání: '"David Frennesson"'
Autor:
Chetan Padmakar Darne, Upender Velaparthi, Mark Saulnier, David Frennesson, Peiying Liu, Audris Huang, John Tokarski, Aberra Fura, Thomas Spires, John Newitt, Vanessa M. Spires, Mary T. Obermeier, Paul A. Elzinga, Marco M. Gottardis, Lata Jayaraman, Gregory D. Vite, Aaron Balog
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
We report herein, the discovery of BMS-737 (compound 33) as a potent, non-steroidal, reversible small molecule inhibitor demonstrating 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase, as well as a clean xenobiotic CYP profile for the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3b381cd62d83515de45641af7f6372
https://pubmed.ncbi.nlm.nih.gov/36031020
https://pubmed.ncbi.nlm.nih.gov/36031020
Autor:
Kyle Parcella, Tao Wang, Kyle Eastman, Zhongxing Zhang, Zhiwei Yin, Manoj Patel, Yong Tu, Barbara Zhizhen Zheng, Michael A. Walker, Mark G. Saulnier, David Frennesson, Michael Bowsher, Eric Gillis, Kevin Peese, Makonen Belema, Christopher Cianci, Ira B. Dicker, Brian McAuliffe, Bo Ding, Paul Falk, Jean Simmermacher, Dawn D. Parker, Prasanna Sivaprakasam, Kevin Kish, Hal Lewis, Umesh Hanumegowda, Susan Jenkins, John F. Kadow, Mark Krystal, Nicholas A. Meanwell, B. Narasimhulu Naidu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Allosteric HIV-1 integrase inhibitors (ALLINIs) have been of interest recently because of their novel mechanism of action. Strategic modifications to the C5 moiety of a class of 4-(4,4-dimethylpiperidinyl)-2,6-dimethylpyridinyl ALLI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef219ff3295f925d0de0c18dbd1bec7
https://europepmc.org/articles/PMC9190037/
https://europepmc.org/articles/PMC9190037/
Autor:
Mark D. Wittman, Joan M. Carboni, Zheng Yang, Francis Y. Lee, Melissa Antman, Ricardo Attar, Praveen Balimane, Chiehying Chang, Cliff Chen, Lorell Discenza, David Frennesson, Marco M. Gottardis, Ann Greer, Warren Hurlburt, Walter Johnson, David R. Langley, Aixin Li, Jianqing Li, Peiying Liu, Harold Mastalerz
Publikováno v:
Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 23, p7360-7363, 4p