Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David Filipovic"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The Brain and Muscle ARNTL-Like 1 protein (BMAL1) forms a heterodimer with either Circadian Locomotor Output Cycles Kaput (CLOCK) or Neuronal PAS domain protein 2 (NPAS2) to act as a master regulator of the mammalian circadian clock gene net
Externí odkaz:
https://doaj.org/article/afb16622c6e24142999a946a39cf2be9
Publikováno v:
Hepatology Communications, Vol 6, Iss 4, Pp 750-764 (2022)
The cytochrome P450 (Cyp) proteins Cyp1A1 and Cyp1A2 are strongly induced in the mouse liver by the potent environmental toxicant 2, 3, 7, 8‐tetrachlorodibenzo‐p‐dioxin (TCDD), acting through the aryl hydrocarbon receptor (AHR). The induction o
Externí odkaz:
https://doaj.org/article/9d611c5721b2479ea020ad41a175421a
Publikováno v:
Environment International, Vol 147, Iss , Pp 106301- (2021)
Predictions from physiologically based toxicokinetic (PBTK) models can help inform human health risk assessment for potentially toxic chemicals in the environment. Bisphenol S (BPS) is the second most abundant bisphenol detected in humans in the Unit
Externí odkaz:
https://doaj.org/article/e2690c9422824bff9ca2735d3a92888d
Publikováno v:
Expert opinion on drug metabolismtoxicology. 18(7-8)
Idiosyncratic drug-induced liver injury (IDILI) causes morbidity and mortality in patients and leads to curtailed use of efficacious pharmaceuticals. Unlike intrinsically toxic reactions, which depend on dose, IDILI occurs in a minority of patients a
Publikováno v:
Hepatology Communications. 6:750-764
The cytochrome P450 (Cyp) proteins Cyp1A1 and Cyp1A2 are strongly induced in the mouse liver by the potent environmental toxicant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), acting through the aryl hydrocarbon receptor (AHR). The induction of Cyp1
The mammalian circadian clock is based on a core intracellular gene regulatory network, coordinated by communication between the central nervous system and peripheral tissues like the liver. Transcriptional and translational feedback loops underlie t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d395252f055d4cb945a21d7196821008
https://doi.org/10.1101/2022.06.27.497767
https://doi.org/10.1101/2022.06.27.497767
Autor:
David Filipovic, Wenjie Qi, Omar Kana, Daniel Marri, Edward L. LeCluyse, Melvin E. Andersen, Suresh Cuddapah, Sudin Bhattacharya
BackgroundThe Aryl Hydrocarbon Receptor (AhR) is an inducible transcription factor (TF) whose ligands include the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD-mediated toxicity occurs through activation of AhR and its su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a51c74957c70be99d6e0f7da3f1233d4
https://doi.org/10.1101/2022.05.13.491754
https://doi.org/10.1101/2022.05.13.491754
Publikováno v:
SSRN Electronic Journal.
Single cell sequencing provides a new opportunity to study the heterogeneity of chemical perturbation within tissues. However, exploring the combinatorial space of all cell type-chemical combinations is experimentally and financially unfeasible. This
Publikováno v:
Environment International, Vol 147, Iss, Pp 106301-(2021)
Environ Int
Environ Int
Predictions from physiologically based toxicokinetic (PBTK) models can help inform human health risk assessment for potentially toxic chemicals in the environment. Bisphenol S (BPS) is the second most abundant bisphenol detected in humans in the Unit
Publikováno v:
Muscle & Nerve. 53:452-463
INTRODUCTION Surface electromyography (SEMG) and mechanomyography (SMMG) responses of the quadriceps during muscular contractions to exhaustion were computed and analyzed by analysis of variance and polynomial regression analyses. METHODS Participant