Zobrazeno 1 - 10
of 332
pro vyhledávání: '"David Fenyö"'
Autor:
Liana Goehring, Sarah Keegan, Sudipta Lahiri, Wenxin Xia, Michael Kong, Judit Jimenez-Sainz, Dipika Gupta, Ronny Drapkin, Ryan B. Jensen, Duncan J. Smith, Eli Rothenberg, David Fenyö, Tony T. Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract BRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we pro
Externí odkaz:
https://doaj.org/article/6eae7c91ca5e4e60a5079c4501597601
Autor:
Leandro Y. S. Okimoto, Rayol Mendonca-Neto, Fabíola G. Nakamura, Eduardo F. Nakamura, David Fenyö, Claudio T. Silva
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background In recent years, researchers have made significant strides in understanding the heterogeneity of breast cancer and its various subtypes. However, the wealth of genomic and proteomic data available today necessitates efficient fram
Externí odkaz:
https://doaj.org/article/bba6169bf35f424e8bdadd9761e3f47f
Autor:
Leticia Szadai, Aron Bartha, Indira Pla Parada, Alexandra I.T. Lakatos, Dorottya M.P. Pál, Anna Sára Lengyel, Natália Pinto de Almeida, Ágnes Judit Jánosi, Fábio Nogueira, Beata Szeitz, Viktória Doma, Nicole Woldmar, Jéssica Guedes, Zsuzsanna Ujfaludi, Zoltán Gábor Pahi, Tibor Pankotai, Yonghyo Kim, Balázs Győrffy, Bo Baldetorp, Charlotte Welinder, A. Marcell Szasz, Lazaro Betancourt, Jeovanis Gil, Roger Appelqvist, Ho Jeong Kwon, Sarolta Kárpáti, Magdalena Kuras, Jimmy Rodriguez Murillo, István Balázs Németh, Johan Malm, David Fenyö, Krzysztof Pawłowski, Peter Horvatovich, Elisabet Wieslander, Lajos V. Kemény, Gilberto Domont, György Marko-Varga, Aniel Sanchez
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionWhile Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI ther
Externí odkaz:
https://doaj.org/article/fe95ef6a509c4265b300a1ff4e58f88f
Autor:
Rachel Ruoff, Hannah Weber, Ying Wang, Hongying Huang, Ellen Shapiro, David Fenyö, Michael J. Garabedian
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract MED19, a component of the mediator complex and a co-regulator of the androgen receptor (AR), is pivotal in prostate cancer cell proliferation. MED19 has two isoforms: a full-length “canonical” and a shorter “alternative” variant. Spe
Externí odkaz:
https://doaj.org/article/9d076138bbdb44f2b8123f663951ef45
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/9cd50dc63ee84311bb1695579de819f3
Autor:
Leticia Szadai, Jéssica de Siqueira Guedes, Nicole Woldmar, Natália Pinto deAlmeida, Ágnes Judit Jánosi, Ahmad Rajeh, Ferenc Kovács, András Kriston, Ede Migh, Guihong Wan, Nga Nguyen, Henriett Oskolás, Roger Appelqvist, Fábio CN Nogueira, Gilberto B Domont, Kun‐Hsing Yu, Eugene R. Semenov, Johan Malm, Melinda Rezeli, Elisabet Wieslander, David Fenyö, Lajos Kemény, Peter Horvath, István Balázs Németh, György Marko‐Varga, Jeovanis Gil
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/f65d8be28fd741cebded9c5880d80da1
Autor:
Niklas Ravn-Boess, Nainita Roy, Takamitsu Hattori, Devin Bready, Hayley Donaldson, Christopher Lawson, Cathryn Lapierre, Aryeh Korman, Tori Rodrick, Enze Liu, Joshua D. Frenster, Gabriele Stephan, Jordan Wilcox, Alexis D. Corrado, Julia Cai, Rebecca Ronnen, Shuai Wang, Sara Haddock, Jonathan Sabio Ortiz, Orin Mishkit, Alireza Khodadadi-Jamayran, Aris Tsirigos, David Fenyö, David Zagzag, Julia Drube, Carsten Hoffmann, Fabiana Perna, Drew R. Jones, Richard Possemato, Akiko Koide, Shohei Koide, Christopher Y. Park, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113374- (2023)
Summary: Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their potential as treatment targets. Here, we show that CD97 (ADGRE5) is the most promi
Externí odkaz:
https://doaj.org/article/e954f101e34e4454841a124bf6a6e405
Autor:
Kritika Srinivasan Rajsri, Michael P. McRae, Nicolaos J. Christodoulides, Isaac Dapkins, Glennon W. Simmons, Hanover Matz, Helen Dooley, David Fenyö, John T. McDevitt
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 670 (2023)
As COVID-19 pandemic public health measures are easing globally, the emergence of new SARS-CoV-2 strains continue to present high risk for vulnerable populations. The antibody-mediated protection acquired from vaccination and/or infection is seen to
Externí odkaz:
https://doaj.org/article/61bc8e1cdb2c491db96d366b554d286c
Autor:
Heyi Yang, Erin R. Butler, Samantha A. Monier, Jennifer Teubl, David Fenyö, Beatrix Ueberheide, Donald Siegel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Proteogenomics is an increasingly common method for species identification as it allows for rapid and inexpensive interrogation of an unknown organism’s proteome—even when the proteome is partially degraded. The proteomic method typicall
Externí odkaz:
https://doaj.org/article/f72890fc2a914052b3c97c1744bba3b2
Autor:
Kuan-lin Huang, Adam D. Scott, Daniel Cui Zhou, Liang-Bo Wang, Amila Weerasinghe, Abdulkadir Elmas, Ruiyang Liu, Yige Wu, Michael C. Wendl, Matthew A. Wyczalkowski, Jessika Baral, Sohini Sengupta, Chin-Wen Lai, Kelly Ruggles, Samuel H. Payne, Benjamin Raphael, David Fenyö, Ken Chen, Gordon Mills, Li Ding
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associa
Externí odkaz:
https://doaj.org/article/f38865e7329d4929ad5179de6e149dde