Zobrazeno 1 - 10
of 67
pro vyhledávání: '"David Falck"'
Autor:
Steven W. de Taeye, Angela I. Schriek, Jeffrey C. Umotoy, Marloes Grobben, Judith A. Burger, Rogier W. Sanders, Gestur Vidarsson, Manfred Wuhrer, David Falck, Neeltje A. Kootstra, Marit J. van Gils
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have the capacity to delay viral rebound when administered to people with HIV-1 (PWH) during anti-retroviral therapy (ART) interruption. To further enhan
Externí odkaz:
https://doaj.org/article/bd55cd58e2634a59b51fc88dc6c76b5f
Autor:
Christoph Gstöttner, Steffen Lippold, Michaela Hook, Feng Yang, Markus Haberger, Manfred Wuhrer, David Falck, Tilman Schlothauer, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The antibody- FcγRIIIa interaction triggers key immunological responses such as antibody dependent cellular cytotoxicity (ADCC), making it highly important for therapeutic mAbs. Due to the direct glycan-glycan interaction with FcγRIIIa receptor, di
Externí odkaz:
https://doaj.org/article/17823215efd24dc59d0603caae56befe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmunoglobulin G (IgG) contains a conserved N-glycan in the fragment crystallizable (Fc), modulating its structure and effector functions. In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) alterations of IgG Fc-gl
Externí odkaz:
https://doaj.org/article/bac6bdbd6bbd4472a110c6ef734320f7
Autor:
Róisín O’Flaherty, Manuela Amez Martín, Richard A. Gardner, Patrick M. Jennings, Pauline M. Rudd, Daniel I. R. Spencer, David Falck
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 125 (2024)
Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. EPO N-glycosylation influences important pharmacological parameters, pr
Externí odkaz:
https://doaj.org/article/7761628facb24ab8a1a57ca707d15dcd
Autor:
David Falck, Martin Lechmann, Ana Momčilović, Marco Thomann, Carolien A. M. Koeleman, Cordula Jany, Sebastian Malik, Manfred Wuhrer, Dietmar Reusch
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, whic
Externí odkaz:
https://doaj.org/article/968dcd0ed8d74a8d99c692168604e66f
Autor:
Iwona Wojcik, David E. Schmidt, Lisa A. de Neef, Minke A. E. Rab, Bob Meek, Okke de Weerdt, Manfred Wuhrer, C. Ellen van der Schoot, Jaap J. Zwaginga, Masja de Haas, David Falck, Gestur Vidarsson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract As a lymphoid organ, the spleen hosts a wide range of immune cell populations, which not only remove blood-borne antigens, but also generate and regulate antigen-specific immune responses. In particular, the splenic microenvironment has been
Externí odkaz:
https://doaj.org/article/be3e529ee6ca40edb4e9c9d2fe655c33
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b8689c4c6d90448f8e050b27a1073d6d
Autor:
Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Immunoglobulin A (IgA) has two subclasses, IgA1 and IgA2, but differential effects on inflammation are unclear. Here the authors show that IgA2, when compared with IgA1, has stronger pro-inflammatory functions associated with changed glycosylation an
Externí odkaz:
https://doaj.org/article/10d5aea8f2dd4168b05d11de004c1d68
Autor:
Steffen Lippold, Simone Nicolardi, Elena Domínguez-Vega, Anna-Katharina Heidenreich, Gestur Vidarsson, Dietmar Reusch, Markus Haberger, Manfred Wuhrer, David Falck
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1191-1196 (2019)
Determination of the impact of individual antibody glycoforms on FcɣRIIIa affinity, and consequently antibody-dependent cell-mediated cytotoxicity (ADCC) previously required high purity glycoengineering. We hyphenated FcɣRIIIa affinity chromatograp
Externí odkaz:
https://doaj.org/article/29cf8fc232b146ef88ded0217ad4cb13
Autor:
Guinevere S. M. Lageveen-Kammeijer, Noortje de Haan, Pablo Mohaupt, Sander Wagt, Mike Filius, Jan Nouta, David Falck, Manfred Wuhrer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan composition
Externí odkaz:
https://doaj.org/article/77741c56da574b2796a64fd252a00dda