Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David F. Nickerson"'
Publikováno v:
Therapeutic innovationregulatory science. 47(2)
The quality of a clinical trial can be assessed by whether the trial meets the needs of its various customers, as well as by its freedom from critical deficiencies or errors. In order to ensure the quality of a clinical trial, it is therefore importa
Autor:
Oicheng Ng, John Inthavongsay, Theresa C. Wilson, Bruce Allen Lefker, Anthony Michael Campeta, Ann S. Wright, Hada William Andrew, John R. Hadcock, David A. Tess, Lydia C. Pan, K.L. Chidsey-Frink, F.Michael Mangano, Steven M. Toler, Colin R. Rose, Ewell R. Cook, Li Yu, C.M. Pirie, David F. Nickerson, Shari L. DeNinno, Joseph DiBrino, John A. Ragan, Paul DaSilva-Jardine, Michelle A. Mullins, David D. Thompson, Philip A. Carpino, Michael P. Zawistoski
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:581-590
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin ( 5 , CP-424391-18, hGHS-R1a K i =7 nM, rat pituicyte EC 50 =3 nM) and the des-methyl analogue 5c (
Autor:
John Inthavongsay, Theresa C. Wilson, Li Yu, Colin R. Rose, Hada William Andrew, Oicheng Ng, John R. Hadcock, David D. Thompson, David F. Nickerson, Michelle A. Mullins, Steven M. Toler, F.Michael Mangano, Paul DaSilva-Jardine, Ewell R. Cook, Bruce Allen Lefker, C.M. Pirie, David A. Tess, Lydia C. Pan, Lewis Sharon K, Michael P. Zawistoski, Ann S. Wright, Joseph DiBrino, K.L. Chidsey-Frink, Murray Marianne C, Philip A. Carpino, Shari L. DeNinno, John C. Pettersen, John A. Ragan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3279-3282
New tert -butyl, picolyl and fluorinated analogues of capromorelin ( 3 ), a short-acting growth hormone secretagogue (GHS), were prepared as part of a program to identify long-acting GHSs that increase 24-h plasma IGF-1 levels. Compounds 4c and 4d (A
Autor:
Bihong Lu, C.M. Pirie, David B. MacLean, David D. Thompson, David F. Nickerson, K.L. Chidsey-Frink, Steven M. Toler, Oicheng Ng, John C. Pettersen, Bruce Allen Lefker, John A. Ragan, Paul DaSilva-Jardine, David A. Tess, Lydia C. Pan, Philip A. Carpino, Michelle A. Mullins, David Nettleton
Publikováno v:
Endocrine. 14:121-132
Growth hormone secretagogues (GHSs) represent attractive therapeutic alternatives to recombinant growth hormone (GH), given their ability to amplify pulsatile hormone secretion in a relatively physiologic manner. CP-424,391 (391) is a novel, orally a
Autor:
Nancy C. Elliott, D.T. Crawford, Thomas A. Brown, Lydia C. Pan, Hua Zhu Ke, Christina M. Tjoa, George T. Tkalcevic, M. J. Cole, D.D. Thompson, C.M. Pirie, Anthony R. Reinhold, Brad Newhouse, P. M. Sweetnam, Robert L. Rosati, Steven M. Toler, Hong Qi, J. W. Gauthier, P. Da Silva Jardine, M. W. Arriola, C. F. Ebbinghaus, Kimberly O. Cameron, H.A. Simmons, David F. Nickerson
Publikováno v:
Journal of Medicinal Chemistry. 41:2928-2931
Autor:
Steven M. Toler, David F. Nickerson
Publikováno v:
Xenobiotica. 27:627-632
1. Employing droloxifene as a probe substrate, we have compared the use of intraperitoneal injection and intraportal infusion, where the rate and duration of intraportal drug administration were designed to approximate those observed after oral drug
Publikováno v:
Xenobiotica. 27:257-264
1. Utilizing a validated ultrasensitive hplc assay (lower limit of quantitation 25 pg/ml), we characterized the disposition profile of droloxifene in the female Sprague-Dawley rat following intravenous, oral and intraportal administration. 2. The sit
Autor:
Cynthia R Zacharias, Judith M. Kramer, Joan Harley, An Liu, David F. Nickerson, Cynthia F Kleppinger, Chrissy J. Cochran, Jennifer Giangrande White, Jules T Mitchel, James D. Neaton, Briggs W. Morrison
Publikováno v:
Clinical trials (London, England). 8(3)
Background There is a little empirical evidence to determine which, if any, monitoring practices best achieve the goals of trial monitoring set forth in ICH E6 under the variable circumstances of different clinical trial settings. Purpose The purpose
Autor:
Philip A, Carpino, Bruce A, Lefker, Steven M, Toler, Lydia C, Pan, John R, Hadcock, Ewell R, Cook, Joseph N, DiBrino, Anthony M, Campeta, Shari L, DeNinno, Kristin L, Chidsey-Frink, William A, Hada, John, Inthavongsay, F Michael, Mangano, Michelle A, Mullins, David F, Nickerson, Oicheng, Ng, Christine M, Pirie, John A, Ragan, Colin R, Rose, David A, Tess, Ann S, Wright, Li, Yu, Michael P, Zawistoski, Paul A, DaSilva-Jardine, Theresa C, Wilson, David D, Thompson
Publikováno v:
Bioorganicmedicinal chemistry. 11(4)
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin (5, CP-424391-18, hGHS-R1a K(i)=7 nM, rat pituicyte EC(50)=3 nM) and the des-methyl analogue 5c (hG
Publikováno v:
Pharmaceutical Research. :1515-1517