Zobrazeno 1 - 10
of 53
pro vyhledávání: '"David F. Kashatus"'
Autor:
Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109451- (2021)
Summary: Lipid droplets (LDs) are dynamic organelles that undergo dynamic changes in response to changing cellular conditions. During nutrient depletion, LD numbers increase to protect cells against toxic fatty acids generated through autophagy and p
Externí odkaz:
https://doaj.org/article/7d1ca44d34e043e18caedbea8c3d9b61
Autor:
Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Syed S. Hussain, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer, David F. Kashatus
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1845-1859.e5 (2019)
Summary: Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk
Externí odkaz:
https://doaj.org/article/3897e3f059e04a41b0a0865493500ca3
Autor:
Christopher M. Counter, Diana M. Cardona, Susan B. Gurley, Rebekah R. White, David F. Kashatus, Matthew S. Crowe, Katharine S. Barrientos, Michael J. Shealy, Meghan M. Morrison, Brooke B. Ancrile, S. DiSean Kendall, Benjamin L. Lampson
PDF file - 164K, L-NAME has minimal effects on cellular proliferation in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e17cfdfae344cf5c77f491738088563
https://doi.org/10.1158/0008-5472.22393610
https://doi.org/10.1158/0008-5472.22393610
Autor:
Christopher M. Counter, Diana M. Cardona, Susan B. Gurley, Rebekah R. White, David F. Kashatus, Matthew S. Crowe, Katharine S. Barrientos, Michael J. Shealy, Meghan M. Morrison, Brooke B. Ancrile, S. DiSean Kendall, Benjamin L. Lampson
PDF file - 243K, eNOS is upregulated in human pancreatic cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca3f72198ac2d5aba9489faf5f2dc2b
https://doi.org/10.1158/0008-5472.22393616
https://doi.org/10.1158/0008-5472.22393616
Autor:
Christopher M. Counter, Diana M. Cardona, Susan B. Gurley, Rebekah R. White, David F. Kashatus, Matthew S. Crowe, Katharine S. Barrientos, Michael J. Shealy, Meghan M. Morrison, Brooke B. Ancrile, S. DiSean Kendall, Benjamin L. Lampson
PDF file - 57K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4a9ff9b22978e40de1771ed1db078d
https://doi.org/10.1158/0008-5472.22393607
https://doi.org/10.1158/0008-5472.22393607
Autor:
Christopher M. Counter, Diana M. Cardona, Susan B. Gurley, Rebekah R. White, David F. Kashatus, Matthew S. Crowe, Katharine S. Barrientos, Michael J. Shealy, Meghan M. Morrison, Brooke B. Ancrile, S. DiSean Kendall, Benjamin L. Lampson
PDF file - 243K, Tumorigenic growth of human pancreatic cancer cell lines treated with L-NAME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7175db537a95e438d4e2faf2b2047167
https://doi.org/10.1158/0008-5472.22393613.v1
https://doi.org/10.1158/0008-5472.22393613.v1
Autor:
Yu Zhang, Caroline P. Riedstra, Sarah Wang, Sonia Patel, Tobias Bald, Pankaj Kumar, Ali Rohani, David F. Kashatus, Stergios J. Moschos, Andrew C. Dudley
Post brain colonization, cancer cells may adhere to and spread along the abluminal surface of the vasculature providing advantageous access to oxygen, nutrients, and vessel-derived paracrine factors. For example, brain-tropic melanoma cells are well-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bde3d6d240dedc1d42fe39dd3364d81
https://doi.org/10.1101/2022.07.15.500231
https://doi.org/10.1101/2022.07.15.500231
Autor:
Dane T. Sessions, Kee-Beom Kim, Jennifer A. Kashatus, Nikolas Churchill, Kwon-Sik Park, Marty W. Mayo, Hiromi Sesaki, David F. Kashatus
SummaryOncogenic KRas activates mitochondrial fission through Erk-mediated phosphorylation of the mitochondrial fission GTPase Drp1. Drp1 deletion inhibits tumorigenesis of KRas-driven pancreatic cancer, but the role of mitochondrial dynamics in othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::135b605fd53498f28cf95463805e4b2b
https://doi.org/10.1101/2022.06.01.494337
https://doi.org/10.1101/2022.06.01.494337
Autor:
Dane T. Sessions, David F. Kashatus
Publikováno v:
Cellular and Molecular Life Sciences. 78:3803-3816
Many tumors are now understood to be heterogenous cell populations arising from a minority of epithelial-like cancer stem cells (CSCs). CSCs demonstrate distinctive metabolic signatures from the more differentiated surrounding tumor bulk that confer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::910f8c50eae2bef8dc46b4a9000d32aa
https://doi.org/10.1007/s00018-021-03773-2
https://doi.org/10.1007/s00018-021-03773-2
Autor:
Dane T, Sessions, Kee-Beom, Kim, Jennifer A, Kashatus, Nikolas, Churchill, Kwon-Sik, Park, Marty W, Mayo, Hiromi, Sesaki, David F, Kashatus
Publikováno v:
Cell reports. 41(11)
Oncogenic KRas activates mitochondrial fission through Erk-mediated phosphorylation of the mitochondrial fission GTPase Drp1. Drp1 deletion inhibits tumorigenesis of KRas-driven pancreatic cancer, but the role of mitochondrial dynamics in other Ras-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2cb8e15c89ee095ebebaa382b3cd16e9
https://pubmed.ncbi.nlm.nih.gov/36516772
https://pubmed.ncbi.nlm.nih.gov/36516772