Zobrazeno 1 - 10
of 270
pro vyhledávání: '"David F. Jarrard"'
Autor:
Tamara S. Rodems, Erika Heninger, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Kristin N. Carlson, Madison R. Kircher, Anupama Singh, Timothy E. G. Krueger, David J. Beebe, David F. Jarrard, Douglas G. McNeel, Michael C. Haffner, Joshua M. Lang
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Loss of HLA-I gene expression in prostate cancer is associated with repressive chromatin states, which can be reversed by pharmacological DNMT and HDAC inhibition leading to increased activation of co-cultured tumor-specific CD8+ T-cells.
Externí odkaz:
https://doaj.org/article/1153e9cc0b6a481e85909d4a3f28af7d
Autor:
Jonathan H. Wang, Pablo Sierra, Kyle A. Richards, E. Jason Abel, Glen O. Allen, Tracy M. Downs, David F. Jarrard
Publikováno v:
BMC Urology, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background To assess factors that can predict active surveillance (AS) failure on serial transrectal ultrasound guided biopsies in patients with low-risk prostate cancer. Methods We evaluated the records of 144 consecutive patients enrolled
Externí odkaz:
https://doaj.org/article/85707b218bca44779c2ac3ed99b25dbb
Autor:
Tyler Etheridge, Shivashankar Damodaran, Adam Schultz, Kyle A. Richards, Joseph Gawdzik, Bing Yang, Vincent Cryns, David F. Jarrard
Publikováno v:
Asian Journal of Urology, Vol 6, Iss 1, Pp 57-64 (2019)
Androgen deprivation therapy (ADT) has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer (PCa). However, this approach is rarely curative. Recent clinical trials have demonstrated that ADT combined with o
Externí odkaz:
https://doaj.org/article/e0c83ab6063445e6bd152cd6075daf92
Autor:
Anthony J. Cesnik, Bing Yang, Andrew Truong, Tyler Etheridge, Michele Spiniello, Maisie I. Steinbrink, Michael R. Shortreed, Brian L. Frey, David F. Jarrard, Lloyd M. Smith
Publikováno v:
Translational Oncology, Vol 11, Iss 3, Pp 808-814 (2018)
INTRODUCTION: The molecular mechanisms underlying aggressive versus indolent disease are not fully understood. Recent research has implicated a class of molecules known as long noncoding RNAs (lncRNAs) in tumorigenesis and progression of cancer. Our
Externí odkaz:
https://doaj.org/article/946ec19bd6de47cfb548eee57a882295
Autor:
Brian P. Johnson, Ross A. Vitek, Peter G. Geiger, Wei Huang, David F. Jarrard, Joshua M. Lang, David J. Beebe
Publikováno v:
BioTechniques, Vol 64, Iss 1, Pp 13-19 (2018)
Cellular heterogeneity within the tissue microenvironment may underlie chemotherapeutic resistance and response, enabling tumor evolution; however, this heterogeneity it is difficult to characterize. Here, we present a new approach—pathology-guided
Externí odkaz:
https://doaj.org/article/381f3c1fdb2449d1af2a4c733b9224c9
Autor:
Nathan A. Damaschke, Bing Yang, Michael L. Blute, Jr., Chee Paul Lin, Wei Huang, David F. Jarrard
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 12, Pp 1018-1027 (2014)
Abnormal expression and function of chromatin regulators results in the altered chromatin structure seen in cancer. The chromatin regulator CTCF, its cofactor CHD8, and antagonistic paralogue BORIS have wide-ranging effects on gene regulation. Their
Externí odkaz:
https://doaj.org/article/7acaa64e4f8e4b7e83ad0053ed96090f
Autor:
Bing Yang, Sachin Bhusari, Jessica Kueck, Pushpa Weeratunga, Jennifer Wagner, Glen Leverson, Wei Huang, David F. Jarrard
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 399-408 (2013)
Prostate cancer (PCa) is typically found as a multifocal disease suggesting the potential for molecular defects within the morphologically normal tissue. The frequency and spatial extent of DNA methylation changes encompassing a potential field defec
Externí odkaz:
https://doaj.org/article/729fc07f6a3e46289ccc47c1544f6f73
Autor:
Steven R. Schwarze, Vivian X. Fu, Joshua A. Desotelle, Michelle L. Kenowski, David F. Jarrard
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 9, Pp 816-823 (2005)
Classic mechanisms of tumor response to chemotherapy include apoptosis, mitotic catastrophe. Recent studies have suggested that cellular senescence, a terminal proliferation arrest seen in vitro, may be invoked during the exposure of cancer cells to
Externí odkaz:
https://doaj.org/article/05d0bced55db428a9e412a53360a2d78
Autor:
William Lowrance, Robert Dreicer, David F. Jarrard, Kristen R. Scarpato, Sennett K. Kim, Erin Kirkby, David I. Buckley, Jessica C. Griffin, Michael S. Cookson
Publikováno v:
Journal of Urology. 209:1082-1090
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae4e3cc2053e092ad20e3406dc77fc0e
https://doi.org/10.1097/ju.0000000000003452
https://doi.org/10.1097/ju.0000000000003452
Autor:
David F. Jarrard, Vincent L. Cryns, Kyle A. Richards, Dmitry Malin, Tyler Etheridge, Joseph Gawdzik, Adam Schultz, Mikolaj J. Filon, Tariq A. Khemees, Shivashankar Damodaran, Bing Yang
The initiation of androgen-deprivation therapy (ADT) induces susceptibilities in prostate cancer cells that make them vulnerable to synergistic treatment and enhanced cell death. Senescence results in cell-cycle arrest, but cells remain viable. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a68edb553efee842491ff4568a7673
https://doi.org/10.1158/1535-7163.c.6542298
https://doi.org/10.1158/1535-7163.c.6542298
