Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David F. Gebhard"'
Publikováno v:
ASSAY and Drug Development Technologies. 17:3-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c860dbb71644be66537b7c7a8b6d491
https://doi.org/10.1089/adt.2018.29085.col
https://doi.org/10.1089/adt.2018.29085.col
Autor:
Ann F. Hoffman, Debra Nickischer, Wienand A. Omta, David F. Gebhard, John Nolan, Judi Wardwell-Swanson, Sam Cooper, Myles Fennell, Sharon Presnell
Publikováno v:
Assay and drug development technologies. 16(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fc14dd7648689f86ca2cb608855b9a
https://pubmed.ncbi.nlm.nih.gov/29345980
https://pubmed.ncbi.nlm.nih.gov/29345980
Autor:
Boris A. Chrunyk, Vincent Mascitti, Michael M. Baksh, Robert Dullea, Marc D. Roy, David Price, Cathy Préville, Carlos A. Sanhueza, Wen Lin, Elnaz Menhaji-Klotz, Meihua Tu, Amanda King-Ahmad, David F. Gebhard, Benjamin A. Thuma, Mark Ammirati, James E. Finley, Christopher T. Salatto, Spiros Liras, Sanjay Dutta, Shenping Liu, Benjamin Reidich, Kevin Beaumont, Ingrid A. Stock, Karen Atkinson, Rajesh Kumar, M. G. Finn
Publikováno v:
Journal of the American Chemical Society. 139(9)
A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were revealed by the first X-ray crystal structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960308770c3c39141859f247dd5ef639
https://pubmed.ncbi.nlm.nih.gov/28230359
https://pubmed.ncbi.nlm.nih.gov/28230359
Autor:
Jitesh P. Jani, Gerrit Los, Kajiji Shama M, Bruce D. Cohen, Green Larry L, Kevin Coleman, Mary Campbell, Jinghai J. Xu, Elsa G. Barbacci-Tobin, Vahe Bedian, Konstantinos Tsaparikos, Jean-Martin Lapointe, Patrick Vincent, Boris A. Chrunyk, Neil R. Michaud, Stephen M. Hillerman, David F. Gebhard, Tim M. Coskran, George A. Karam, Margaret C. Dunn, Elisabeth Knauth, Stefan J. Steyn, Henry Putz, Gary Borzillo
Publikováno v:
mAbs. 4:710-723
The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by its ligand, hepatocyte growth factor (HGF), to induce cell growth, motility and morphogenesis. Dysregulation of c-Met function, through mutational activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7724a3acb9187edf4bc1c797bd35ec1f
https://doi.org/10.4161/mabs.22160
https://doi.org/10.4161/mabs.22160
Publikováno v:
European Journal of Gastroenterology & Hepatology. 24:563-574
Tumor recurrence and metastasis is the most common cause of mortality in hepatocellular carcinoma (HCC) patients. Despite positive results with vascular endothelial growth factor (VEGF) inhibitors in preclinical studies using HCC xenograft models, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d48ea17b578dbd20385678792194f23
https://doi.org/10.1097/meg.0b013e328350916f
https://doi.org/10.1097/meg.0b013e328350916f
Autor:
Hui Zhang, Russ Smith, Caroline A. Lee, Manthena V.S. Varma, Matthew D. Troutman, Charles J. Rotter, James Federico, Theodore E. Liston, Sarah Kempshall, Katherine S. Fenner, Ralph E. Davidson, Xun Zhang, John P. Umland, Carrie Whitney-Pickett, Li Di, Bo Feng, Yurong Lai, Ayman El-Kattan, Eric L. Reyner, David F. Gebhard
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4974-4985
Permeability is an important property of drug candidates. The Madin-Darby canine kidney cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK cells is the presence of endogenous transporters of nonhuman origin. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3a981abdfe2a87c8847b6b6db20f3f
https://doi.org/10.1002/jps.22674
https://doi.org/10.1002/jps.22674
Publikováno v:
Toxicology in Vitro. 25:715-723
Lysosomes are acidic organelles that are essential for the degradation of old organelles and engulfed microbes. Furthermore, lysosomes play a key role in cell death. Lipophilic or amphiphilic compounds with a basic moiety can become protonated and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606038e8fb4efd734c3f6037fec38422
https://doi.org/10.1016/j.tiv.2010.12.010
https://doi.org/10.1016/j.tiv.2010.12.010
Publikováno v:
SLAS Discovery. 15:937-948
Compounds that interfere with the synthesis of either mitochondrial DNA or mtDNA-encoded proteins reduce the levels of 13 proteins essential for oxidative phosphorylation, leading to a decrease in mitochondrial adenosine triphosphate (ATP) production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c5496b8b1f323e92847bdff161ca98
https://doi.org/10.1177/1087057110373547
https://doi.org/10.1177/1087057110373547
Publikováno v:
Current Protocols in Toxicology
Compounds that impair the synthesis of either mitochondrial DNA (mtNDA) or mtDNA-encoded proteins reduce the levels of 13 proteins essential for oxidative phosphorylation, leading to a decrease in mitochondrial ATP production. Toxicity caused by thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e25d51ea18918881b6c914f5c369c7
https://doi.org/10.1002/0471140856.tx0311s48
https://doi.org/10.1002/0471140856.tx0311s48
Autor:
Lydia C. Pan, Vishwas M. Paralkar, D.T. Crawford, Thomas A. Owen, Thomas A. Brown, Kelly R. Long, Steven L. Smock, John E. Hambor, Mei Li, Peter C. Bonnette, Leonard Buckbinder, John Charles Kath, W. Gregory Roberts, David F. Gebhard, Hollis A. Simmons, Angel Guzman-Perez, Michael Joseph Luzzio, Catherine Angela Hulford, Hua Zhu Ke, Amy P. Baumann, Lisa M. Olson, Hong Qi, William A. Grasser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(25)
Bone is accrued and maintained primarily through the coupled actions of bone-forming osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that proline-rich tyrosine kinase 2 (PYK2) is a positive mediator of osteoclast fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bced4831fc4cac3ea1ee6f697503c8c4
https://pubmed.ncbi.nlm.nih.gov/17581868
https://pubmed.ncbi.nlm.nih.gov/17581868