Zobrazeno 1 - 10
of 154
pro vyhledávání: '"David F Wozniak"'
Autor:
Rachel A Idol, David F Wozniak, Hideji Fujiwara, Carla M Yuede, Daniel S Ory, Stuart Kornfeld, Peter Vogel
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109768 (2014)
UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is an α2β2γ2 hexameric enzyme that catalyzes the synthesis of the mannose 6-phosphate targeting signal on lysosomal hydrolases. Mutations in the α/β subunit precursor gene caus
Externí odkaz:
https://doaj.org/article/2c86718f77f3467eb9dd19a43ebee97a
Autor:
David F Wozniak, Kelly A Diggs-Andrews, Sara Conyers, Carla M Yuede, Joshua T Dearborn, Jacquelyn A Brown, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F Zorumski, David H Gutmann
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66024 (2013)
Children with neurofibromatosis type 1 (NF1) frequently have cognitive and behavioral deficits. Some of these deficits have been successfully modeled in Nf1 genetically-engineered mice that develop optic gliomas (Nf1 OPG mice). In the current study,
Externí odkaz:
https://doaj.org/article/53ca7f9a2d8f4fef890d35d461b66817
Autor:
Chihiro Sato, Mustafa Turkoz, Joshua T Dearborn, David F Wozniak, Raphael Kopan, Matthew R Hass
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48180 (2012)
Previous studies suggest that loss of γ-secretase activity in postnatal mouse brains causes age-dependent memory impairment and neurodegeneration. Due to the diverse array of γ-secretase substrates, it remains to be demonstrated whether loss of cle
Externí odkaz:
https://doaj.org/article/866e48f701074e758bca789c28719da6
Autor:
Carla M Yuede, David F Wozniak, Catherine E Creeley, George T Taylor, John W Olney, Nuri B Farber
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11374 (2010)
Exposure to NMDA glutamate antagonists during the brain growth spurt period causes widespread neuroapoptosis in the rodent brain. This period in rodents occurs during the first two weeks after birth, and corresponds to the third trimester of pregnanc
Externí odkaz:
https://doaj.org/article/1aa4e09181e140a0bb0aa3a5d7b1eed2
Autor:
Coy D Heldermon, Anne K Hennig, Kevin K Ohlemiller, Judith M Ogilvie, Erik D Herzog, Annalisa Breidenbach, Carole Vogler, David F Wozniak, Mark S Sands
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e772 (2007)
Mucopolysaccharidosis (MPS) IIIB (Sanfilippo Syndrome type B) is caused by a deficiency in the lysosomal enzyme N-acetyl-glucosaminidase (Naglu). Children with MPS IIIB develop disturbances of sleep, activity levels, coordination, vision, hearing, an
Externí odkaz:
https://doaj.org/article/d5e720ff5f7c4bf9810d566bd4f57c79
Autor:
Teresa C Leone, John J Lehman, Brian N Finck, Paul J Schaeffer, Adam R Wende, Sihem Boudina, Michael Courtois, David F Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O Holloszy, Denis M Medeiros, Robert E Schmidt, Jeffrey E Saffitz, E Dale Abel, Clay F Semenkovich, Daniel P Kelly
Publikováno v:
PLoS Biology, Vol 3, Iss 4, p e101 (2005)
The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice. PGC-1alpha null (PGC-1alpha(-/-)) mice were viable. However, extensive phenotyping revealed multi
Externí odkaz:
https://doaj.org/article/16bb1d9b02ff480aa13aad3087d82569
Autor:
Hong-Jin Shu, Luke H. Ziolkowski, Sofia V. Salvatore, Ann M. Benz, David F. Wozniak, Carla M. Yuede, Steven M. Paul, Charles F. Zorumski, Steven Mennerick
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 254 (2024)
Brain cholesterol metabolic products include neurosteroids and oxysterols, which play important roles in cellular physiology. In neurons, the cholesterol oxidation product, 24S-hydroxycholesterol (24S-HC), is a regulator of signaling and transcriptio
Externí odkaz:
https://doaj.org/article/8f64cddbe0f843c7a857f9ccbff220df
Autor:
Brittany A. Townley, Luke Buerer, Albino Bacolla, Timur Rusanov, Nicolas Schmidt, Sridhar N. Srivatsan, Nathanial E. Clark, Fadhel Mansoori, Reilly A. Sample, Joshua R. Brickner, Drew McDonald, Miaw-Sheue Tsai, Matthew J. Walter, David F. Wozniak, Alex S. Holehouse, John A. Tainer, William G. Fairbrother, Nima Mosammaparast
SummaryThe pre-mRNA life cycle requires intron processing; yet, how intron processing defects influence splicing and gene expression is unclear. Here, we find TTDN1, which is frequently mutated in non-photosensitive trichothiodystrophy (NP-TTD), func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0503367ec9efd5d220936eb37c95bca
https://doi.org/10.1101/2022.11.03.515106
https://doi.org/10.1101/2022.11.03.515106
Autor:
Sruthi Ramagiri, Shelei Pan, Dakota DeFreitas, Peter H. Yang, Dhvanii K. Raval, David F. Wozniak, Prabagaran Esakky, Jennifer M. Strahle
Publikováno v:
Translational Stroke Research.
Autor:
Lane C. Porter, Yo Sasaki, Subhadra Gunawardana, Michael Wong, David W. Piston, Michael P Franczyk, Jun Yoshino, Kelly L Stromsdorfer, Nicholas Rensing, Nathan Qi, Samuel Klein, Shintaro Yamaguchi, David F. Wozniak, Maria Chondronikola
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 47
Nicotinamide adenine dinucleotide (NAD + ) is a critical coenzyme for cellular energy metabolism. The aim of the present study was to determine the importance of brown and white adipose tissue (BAT and WAT) NAD + metabolism in regulating whole-body t