Výsledky vyhledávání - "David F Stern"

Akademický článek

Treatment scheduling effects on the evolution of drug resistance in heterogeneous cancer cell populations

Autor: Gauri A. Patwardhan, Michal Marczyk, Vikram B. Wali, David F. Stern, Lajos Pusztai, Christos Hatzis

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)

Abstract The effect of scheduling of targeted therapy combinations on drug resistance is underexplored in triple-negative breast cancer (TNBC). TNBC constitutes heterogeneous cancer cell populations the composition of which can change dynamically dur

Externí odkaz: https://doaj.org/article/2761058a831d4c5bb0c7d0fdb6e51e5e

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Akademický článek

Identifying modules of cooperating cancer drivers

Autor: Michael I Klein, Vincent L Cannataro, Jeffrey P Townsend, Scott Newman, David F Stern, Hongyu Zhao

Publikováno v: Molecular Systems Biology, Vol 17, Iss 3, Pp 1-28 (2021)

Abstract Identifying cooperating modules of driver alterations can provide insights into cancer etiology and advance the development of effective personalized treatments. We present Cancer Rule Set Optimization (CRSO) for inferring the combinations o

Externí odkaz: https://doaj.org/article/6019ff0ef7ef483ab82c56178e4ef11f

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Akademický článek

GRAPE: a pathway template method to characterize tissue-specific functionality from gene expression profiles

Autor: Michael I. Klein, David F. Stern, Hongyu Zhao

Publikováno v: BMC Bioinformatics, Vol 18, Iss 1, Pp 1-16 (2017)

Abstract Background Personalizing treatment regimes based on gene expression profiles of individual tumors will facilitate management of cancer. Although many methods have been developed to identify pathways perturbed in tumors, the results are often

Externí odkaz: https://doaj.org/article/05e8cc4f685c4a1b967e01bd9a2f5686

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Data from BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume

Autor: Marcus W. Bosenberg, David F. Stern, Richard A. Scolyer, Georgina V. Long, Goran Micevic, Katrina M. Meeth, Alexander Marzuka-Alcala, Matthew A. Held, Nicholas Theodosakis

BRAF kinase inhibitors have dramatically affected treatment of BRAFV600E/K-driven metastatic melanoma. Early responses assessed using [18F]fluorodeoxyglucose uptake-positron emission tomography (FDG-PET) have shown dramatic reduction of radiotracer s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5f41ce50384eb3dfebaf45da23b722
https://doi.org/10.1158/1535-7163.c.6537120

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Supplementary Figures 1-7 from Genotype-Selective Combination Therapies for Melanoma Identified by High-Throughput Drug Screening

Autor: David F. Stern, Marcus W. Bosenberg, Jonathan W. Haskins, Andrew Koo, Antonella Bacchiocchi, Ashok Chakraborty, Zongzhi Liu, Tisheeka Graham-Steed, James T. Platt, Casey G. Langdon, Matthew A. Held

PDF file - 1.1MB, Figure S1. Single agent concentration-effect curves, related to Figure 1; Figure S2. Drug class and concentration choices for combinatorial drug screening, related to Figure 2; Figure S3, Mutant BRAF and mutant RAS selective drug pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eae7527ca5c5d876d8e33fa33b99f5d
https://doi.org/10.1158/2159-8290.22528706.v1

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