Zobrazeno 1 - 10
of 277
pro vyhledávání: '"David F Schaeffer"'
Autor:
Basile Tessier‐Cloutier, Jasleen K Grewal, Martin R Jones, Erin Pleasance, Yaoqing Shen, Ellen Cai, Chris Dunham, Lynn Hoang, Basil Horst, David G Huntsman, Diana Ionescu, Anthony N Karnezis, Anna F Lee, Cheng Han Lee, Tae Hoon Lee, David DW Twa, Andrew J Mungall, Karen Mungall, Julia R Naso, Tony Ng, David F Schaeffer, Brandon S Sheffield, Brian Skinnider, Tyler Smith, Laura Williamson, Ellia Zhong, Dean A Regier, Janessa Laskin, Marco A Marra, C Blake Gilks, Steven JM Jones, Stephen Yip
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 4, Pp 395-407 (2022)
Abstract In this study, we evaluate the impact of whole genome and transcriptome analysis (WGTA) on predictive molecular profiling and histologic diagnosis in a cohort of advanced malignancies. WGTA was used to generate reports including molecular al
Externí odkaz:
https://doaj.org/article/a901dba17e554a43930f20607375541d
Autor:
Brian G Feagan, Vipul Jairath, Reetesh K Pai, Rish K Pai, Amitabh Srivastava, Christopher Ma, Christophe Rosty, David F Schaeffer, Roger M Feakins, Gregory Y Lauwers, Jonathan Krell, Richard Kirsch, Leonardo Guizzetti, John K MacDonald, Won-Tak Choi, Stefanie C McFarlane, Joanna C. Walsh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Immune checkpoint inhibitor-associated colitis (ICIC) affects approximately 15% of cancer patients treated with immunotherapy. Although histological evaluation is potentially valuable for both the diagnosis of ICIC and evaluation of disease activity,
Externí odkaz:
https://doaj.org/article/68c745c8e80e44898d2db6645e7a63b2
Publikováno v:
Biomarker Insights, Vol 16 (2021)
Biobanking efforts, to establish and grow the pool of available tissue from which evidence on aetiology, therapeutic susceptibility and prognosis of various diseases, have been underway for decades. This is illustrated nowhere better than in cancer.
Externí odkaz:
https://doaj.org/article/b91ee6ed509344bab1b5753ed55e0e5f
Autor:
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tu
Externí odkaz:
https://doaj.org/article/a2c84c9d9241460d889b4c891a5bea32
Autor:
Leah M Prentice, Ruth R Miller, Jeff Knaggs, Alborz Mazloomian, Rosalia Aguirre Hernandez, Patrick Franchini, Kourosh Parsa, Basile Tessier-Cloutier, Anna Lapuk, David Huntsman, David F Schaeffer, Brandon S Sheffield
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196434 (2018)
Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies, this tissue processing approach remains the
Externí odkaz:
https://doaj.org/article/6f3c52d52f0d4361bc038bbf1bfffd51
Autor:
Brandon S Sheffield, Anna V Tinker, Yaoqing Shen, Harry Hwang, Hector H Li-Chang, Erin Pleasance, Carolyn Ch'ng, Amy Lum, Julie Lorette, Yarrow J McConnell, Sophie Sun, Steven J M Jones, Allen M Gown, David G Huntsman, David F Schaeffer, Andrew Churg, Stephen Yip, Janessa Laskin, Marco A Marra
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119689 (2015)
Peritoneal mesothelioma is a rare and sometimes lethal malignancy that presents a clinical challenge for both diagnosis and management. Recent studies have led to a better understanding of the molecular biology of peritoneal mesothelioma. Translation
Externí odkaz:
https://doaj.org/article/4f3de692f9ac46a2bc63032e438a5210
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 28, Iss 4, Pp 183-183 (2014)
Externí odkaz:
https://doaj.org/article/fcf3e28a6e53424ebf1147e4c9374d90
Autor:
Kiyoshi Saeki, Ian S. Wood, Wei Chuan Kevin Wang, Shilpa Patil, Yanping Sun, David F. Schaeffer, Gloria H. Su, Janel L. Kopp
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 5, Pp 101387- (2024)
Background & Aims: Pancreatic ductal adenocarcinoma can develop from precursor lesions, including pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm (IPMN). Previous studies indicated that loss of Acvr1b accelerates the
Externí odkaz:
https://doaj.org/article/c27ef1153cab422c94a5c4539953f4d7
Autor:
Erica S. Tsang, Veronika Csizmok, Laura M. Williamson, Erin Pleasance, James T. Topham, Joanna M. Karasinska, Emma Titmuss, Intan Schrader, Stephen Yip, Basile Tessier-Cloutier, Karen Mungall, Tony Ng, Sophie Sun, Howard J. Lim, Jonathan M. Loree, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. We reviewed whole genome (WGS) and transcriptomic (RNA-Seq) data
Externí odkaz:
https://doaj.org/article/94cf2e36a62f41e6b8a8f4c6c8888bcf
Autor:
Jannat Pervin, Mohammad Asad, Shaolong Cao, Gun Ho Jang, Nikta Feizi, Benjamin Haibe-Kains, Joanna M. Karasinska, Grainne M. O’Kane, Steven Gallinger, David F. Schaeffer, Daniel J. Renouf, George Zogopoulos, Oliver F. Bathe
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by a diverse tumor microenvironment. The heterogeneous cellular composition of PDAC makes it challenging to study molecular features of tumor cells using extracts f
Externí odkaz:
https://doaj.org/article/ec92d12728a044ddbf9be245d2f7b7e0