Zobrazeno 1 - 10
of 196
pro vyhledávání: '"David Eliezer"'
Autor:
Kathryn E. Carnazza, Lauren E. Komer, Ying Xue Xie, André Pineda, Juan Antonio Briano, Virginia Gao, Yoonmi Na, Trudy Ramlall, Vladimir L. Buchman, David Eliezer, Manu Sharma, Jacqueline Burré
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114280- (2024)
Externí odkaz:
https://doaj.org/article/92f1178b930f40d6a128c73a29fb7909
Autor:
Meraj Ramezani, Alice Wagenknecht-Wiesner, Tong Wang, David A. Holowka, David Eliezer, Barbara A. Baird
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-18 (2023)
Abstract Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson’s disease (PD). Despite the biomedical importance and extensive studies, th
Externí odkaz:
https://doaj.org/article/cd9587de17e542339557bedbf39af0c3
Autor:
Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/8849caad15a2425b9a9463a3e1b93bff
Autor:
Mustafa T. Ardah, Simona S. Ghanem, Sara A. Abdulla, Guohua Lv, Mohamed M. Emara, Katerina E. Paleologou, Nishant N. Vaikath, Jia-Hong Lu, Min Li, Konstantinos Vekrellis, David Eliezer, Omar M. A. El-Agnaf
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-21 (2020)
Abstract Background Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson’s disease (PD), multiple system atrophy, and dementia with
Externí odkaz:
https://doaj.org/article/20d1bd5274794f01b0343a5862a81e46
Autor:
Tapojyoti Das, Meraj Ramezani, David Snead, Cristian Follmer, Peter Chung, Ka Yee Lee, David A. Holowka, Barbara A. Baird, David Eliezer
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1816 (2022)
Alpha-synuclein is a presynaptic protein linked to Parkinson’s disease with a poorly characterized physiological role in regulating the synaptic vesicle cycle. Using RBL-2H3 cells as a model system, we earlier reported that wild-type alpha-synuclei
Externí odkaz:
https://doaj.org/article/f60c6c30da694b5eb9dac1e470eda639
Autor:
Anqesha Murray, Lufeng Yan, James M. Gibson, Jian Liu, David Eliezer, Guy Lippens, Fuming Zhang, Robert J. Linhardt, Jing Zhao, Chunyu Wang
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1573 (2022)
(1) Background: Prion-like transcellular spreading of tau pathology in Alzheimer’s disease (AD) is mediated by tau binding to the cell-surface glycan heparan sulfate (HS). However, the structural determinants for tau–HS interaction are not well u
Externí odkaz:
https://doaj.org/article/f08da5c8279344e89925ab74160bfd28
Autor:
Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A. Lashuel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligom
Externí odkaz:
https://doaj.org/article/a9accbe2206844e88e73f54fa7b62a03
Publikováno v:
eLife, Vol 8 (2019)
Previously we identified Lam/GramD1 proteins, a family of endoplasmic reticulum membrane proteins with sterol-binding StARkin domains that are implicated in intracellular sterol homeostasis. Here, we show how these proteins exchange sterol molecules
Externí odkaz:
https://doaj.org/article/b6f15e33191b4cdfb4c28e5054182cec
Autor:
Mustafa T. Ardah, Katerina E. Paleologou, Guohua Lv, Sindhu A. Menon, Salema B. Abul Khair, Jia-Hong Lu, Bared Safieh-Garabedian, Abdulmonem A. Al-Hayani, David Eliezer, Min Li, Omar M.A. El-Agnaf
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 89-101 (2015)
Compelling evidence indicates that α-synuclein (α-syn) aggregation plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. Identification of compounds that inhibit or reverse the aggregation process may thu
Externí odkaz:
https://doaj.org/article/91b2330bcb1a4318823c42817abb03d5
Autor:
David Eliezer
Publikováno v:
eLife, Vol 6 (2017)
A disordered region at the N-terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an allosteric mechanism.
Externí odkaz:
https://doaj.org/article/0fbb8b42a982417b9fd5137746f5b620