Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David E. Weinberg"'
In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing
Publikováno v:
eLife, Vol 6 (2017)
Ribosomes can stall during translation due to defects in the mRNA template or translation machinery, leading to the production of incomplete proteins. The Ribosome-associated Quality control Complex (RQC) engages stalled ribosomes and targets nascent
Externí odkaz:
https://doaj.org/article/146abd0c3170436d8c7cea4a37aa3e87
Publikováno v:
eLife, Vol 5 (2016)
HAC1 encodes a transcription factor that is the central effector of the unfolded protein response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an unspliced isoform in the cytoplasm and no Hac1 protein is detectable. Intron
Externí odkaz:
https://doaj.org/article/c69f067ba1a44c28be21ce95efbf52da
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613733
Methods Mol Biol
Methods Mol Biol
The family of radical SAM RNA-methylating enzymes comprises a large group of proteins that contains only a few functionally characterized members. Several enzymes in this family have been implicated in the regulation of translation and antibiotic sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51b636c7e996a90a735ce3fc4461b86
https://doi.org/10.1007/978-1-0716-1374-0_7
https://doi.org/10.1007/978-1-0716-1374-0_7
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa468⟩
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa468⟩
RNA interference (RNAi) is a gene-silencing pathway that can play roles in viral defense, transposon silencing, heterochromatin formation and post-transcriptional gene silencing. Although absent from Saccharomyces cerevisiae, RNAi is present in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0024943251f93b26d33529f2e292268
https://hal.archives-ouvertes.fr/hal-03064992
https://hal.archives-ouvertes.fr/hal-03064992
RNA interference (RNAi) is a gene-silencing pathway that can play roles in viral defense, transposon silencing, heterochromatin formation, and post-transcriptional gene silencing. Although absent fromSaccharomyces cerevisiae, RNAi is present in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cee64aca4e3a3776b98a9cab9b6dac
https://doi.org/10.1101/2019.12.12.873604
https://doi.org/10.1101/2019.12.12.873604
Autor:
Abraham Tzou, Jennifer Pecson, Tzu-Yu Liu, Signe Fransen, John St. John, David E. Weinberg, Riley Ennis, Yaping Liu, Brandon J. Rice, Daniel Delubac, Nathan Boley, Marvin Bertin, Katherine E. Niehaus, Leilani Young, Aarushi Sharma, Girish Putcha, Adam Drake, James Cregg, Erik Gafni, Nathan Wan, Catherina Tang, Derek Bowen, Brandon White, Imran S. Haque, Ajay Kannan, Mitch Bailey, Gabriel E. Sanderson, Eric A. Ariazi, Gabriel Otte, Loren Hansen
Publikováno v:
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
BackgroundBlood-based methods using cell-free DNA (cfDNA) are under development as an alternative to existing screening tests. However, early-stage detection of cancer using tumor-derived cfDNA has proven challenging because of the small proportion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ac7ac8fea1c37b4c91bf798c0a4eff
https://pubmed.ncbi.nlm.nih.gov/31443703
https://pubmed.ncbi.nlm.nih.gov/31443703
Autor:
Krishnan K. Palaniappan, Mitch Bailey, David E. Weinberg, Tzu-Yu Liu, Anne-Marie Martin, Nancy Krunic, C. Jimmy Lin, Peter Ulz, Irving Wang, Hayley Warsinske, Riley Ennis, Francesco Vallania, Karen Assayag
Publikováno v:
Cancer Research. 80:2433-2433
Blood-based markers can be used to non-invasively predict cancer progression after treatment. Here, cell-free DNA (cfDNA) and plasma proteins were evaluated to explore biological signatures of progression in non-small cell lung cancer (NSCLC). Baseli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d55a8fed912b46a3aaccd4a4dbfee9e
https://doi.org/10.1158/1538-7445.am2020-2433
https://doi.org/10.1158/1538-7445.am2020-2433
Publikováno v:
J Am Chem Soc
Although present across bacteria, the large family of radical SAM RNA methylating enzymes is largely uncharacterized. Escherichia coli RlmN, the founding member of the family, methylates an adenosine in 23S rRNA and several tRNAs to yield 2-methylade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51909d0ed38b2394c37175fbd682e51
https://europepmc.org/articles/PMC7207077/
https://europepmc.org/articles/PMC7207077/
Publikováno v:
RNA (New York, N.Y.), vol 24, iss 2
Changes in the 5′ leader of an mRNA can have profound effects on its translational efficiency with little effect on abundance. Sequencing-based methods to accurately map the 5′ leader by identifying the first transcribed nucleotide rely on enzyma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c986501a452b65301cebc937ceab47
https://escholarship.org/uc/item/1hk6p2n0
https://escholarship.org/uc/item/1hk6p2n0
Publikováno v:
Bio-protocol
The efficiency with which proteins are produced from mRNA molecules can vary widely across transcripts, cell types, and cellular states. Methods that accurately assay the translational efficiency of mRNAs are critical to gaining a mechanistic underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab76428fd89e410899d01b1ca4e974de
https://pubmed.ncbi.nlm.nih.gov/29170751
https://pubmed.ncbi.nlm.nih.gov/29170751