Zobrazeno 1 - 10
of 17
pro vyhledávání: '"David E. Scheim"'
Publikováno v:
Gynecologic Oncology Reports, Vol 51, Iss , Pp 101324- (2024)
Up to 30 % of COVID-infected patients may develop post-acute sequelae of COVID-19 (PASC), also known as Long COVID (LC), a syndrome characterized by a variety of debilitating symptoms lasting for more than 3 months after the acute infection. While th
Externí odkaz:
https://doaj.org/article/b9c2e6db927c46d0abad4bbc55e50e26
Autor:
David E. Scheim, Peter I. Parry, David J. Rabbolini, Colleen Aldous, Morimasa Yagisawa, Robert Clancy, Thomas J. Borody, Wendy E. Hoy
Publikováno v:
Viruses, Vol 16, Iss 4, p 647 (2024)
Consistent with the biochemistry of coronaviruses as well established over decades, SARS-CoV-2 makes its initial attachment to host cells through the binding of its spike protein (SP) to sialylated glycans (containing the monosaccharide sialic acid)
Externí odkaz:
https://doaj.org/article/0bb652d4f1a34038bc2285f03ffa90f2
Publikováno v:
BioMedInformatics, Vol 2, Iss 4, Pp 553-564 (2022)
Omicron is the dominant strain of COVID-19 in the United States and worldwide. Although this variant is highly transmissible and may evade natural immunity, vaccines, and therapeutic antibodies, preclinical results in animal models and clinical data
Externí odkaz:
https://doaj.org/article/6224b96a11304c988037fbf9b4310f82
Autor:
Jaqueline C. Stone, Pisirai Ndarukwa, David E. Scheim, Barry M. Dancis, Jerome Dancis, Martin G. Gill, Colleen Aldous
Publikováno v:
Biologics, Vol 2, Iss 3, Pp 196-210 (2022)
The emergence of COVID-19 in March 2020 challenged Zimbabwe to respond with limited medical facilities and therapeutic options. Based on early clinical indications of efficacy for the macrocyclic lactone, Ivermectin (IVM), against COVID-19, IVM-based
Externí odkaz:
https://doaj.org/article/4a148ef3173942e0bace4d34d8c7a008
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 17039 (2023)
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus’s pathology. SARS-CoV-2 SP attaches to and aggregates red blood cells
Externí odkaz:
https://doaj.org/article/95b1145981b141de86f5de3334c0381b
Autor:
Paola Vottero, Scott Tavernini, Alessandro D. Santin, David E. Scheim, Jack A. Tuszynski, Maral Aminpour
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11449 (2023)
Hypercoagulability and formation of extensive and difficult-to-lyse microclots are a hallmark of both acute COVID-19 and long COVID. Fibrinogen, when converted to fibrin, is responsible for clot formation, but abnormal structural and mechanical clot
Externí odkaz:
https://doaj.org/article/4ed924aba1134abd9e9e8f50e3209b5c
Autor:
Celine Boschi, David E. Scheim, Audrey Bancod, Muriel Militello, Marion Le Bideau, Philippe Colson, Jacques Fantini, Bernard La Scola
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15480 (2022)
Experimental findings for SARS-CoV-2 related to the glycan biochemistry of coronaviruses indicate that attachments from spike protein to glycoconjugates on the surfaces of red blood cells (RBCs), other blood cells and endothelial cells are key to the
Externí odkaz:
https://doaj.org/article/58abb17709494fb08af270873a7fa8d8
Autor:
Maral Aminpour, Marco Cannariato, Jordane Preto, M. Ehsan Safaeeardebili, Alexia Moracchiato, Domiziano Doria, Francesca Donato, Eric Adriano Zizzi, Marco Agostino Deriu, David E. Scheim, Alessandro D. Santin, Jack Adam Tuszynski
Publikováno v:
Computation, Vol 10, Iss 4, p 51 (2022)
Some clinical studies have indicated activity of ivermectin, a macrocyclic lactone, against COVID-19, but a biological mechanism initially proposed for this anti-viral effect is not applicable at physiological concentrations. This in silico investiga
Externí odkaz:
https://doaj.org/article/e6955eea9d134214b507a187472c4042
Autor:
David E. Scheim
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2558 (2022)
Rouleaux (stacked clumps) of red blood cells (RBCs) observed in the blood of COVID-19 patients in three studies call attention to the properties of several enveloped virus strains dating back to seminal findings of the 1940s. For COVID-19, key such p
Externí odkaz:
https://doaj.org/article/926da05770e744e5a8bdd0fea06e7578
Publikováno v:
Journal of Clinical Medicine. 12:3625
Under exceptional circumstances, including high rates of protocol non-compliance, per-protocol (PP) analysis can better indicate the real-world benefits of a medical intervention than intention-to-treat (ITT) analysis. Exemplifying this, the first ra