Zobrazeno 1 - 10
of 113
pro vyhledávání: '"David E. Ray"'
Autor:
Mabruka H. Tarhoni, Vasanthy Vigneswara, Marie Smith, Susan Anderson, Peter Wigmore, John E. Lees, David E. Ray, Wayne G. Carter
Publikováno v:
Molecules, Vol 16, Iss 10, Pp 8535-8551 (2011)
Organophosphorus (OP) compounds are a diverse chemical group that includes nerve agents and pesticides. They share a common chemical signature that facilitates their binding and adduction of acetylcholinesterase (AChE) within nerve synapses to induce
Externí odkaz:
https://doaj.org/article/c28efa82d2e24131b7c435f57c783e51
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61442 (2013)
Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of
Externí odkaz:
https://doaj.org/article/bd4901aa710d4234a1cc6185ab57c939
Autor:
Si Qin, Mark Epping-Jordan, David A. Kendall, Charles A. Marsden, Ben H.C. Westerink, David E. Ray, Emmanuel Le Poul, Kevin C. F. Fone, Nektaria Papadopoulou, Nisha Kurian, Tyson V. Sharp, Madeleine V. King, Thomas I. F. H. Cremers
Publikováno v:
Neuropsychopharmacology, 39(2), 464-476. Nature Publishing Group
Glutamate is the principle excitatory neurotransmitter in the mammalian brain, and dysregulation of glutamatergic neurotransmission is implicated in the pathophysiology of several psychiatric and neurological diseases. This study utilized novel lenti
Publikováno v:
Journal of Neurochemistry. 116:996-1004
We have previously shown that systemic administration of S(+)3-chloropropanediol (3-CPD) produces a morphological loss of astrocytes in specific nuclei of the rodent brain that precedes loss of both neurones and endothelial tight junctions. Here, we
Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides
Autor:
Steve Symington, Larry R. Holden, J. Marshall Clark, Larry P. Sheets, Nicholas C. Sturgess, Charles B. Breckenridge, Jin-Sung Choi, David M. Soderlund, Myra L. Weiner, Steve Burr, Dana Sargent, David E. Ray
Publikováno v:
NeuroToxicology. 30:S17-S31
Neurotoxicity and mechanistic data were collected for six alpha-cyano pyrethroids (beta-cyfluthrin, cypermethrin, deltamethrin, esfenvalerate, fenpropathrin and lambda-cyhalothrin) and up to six non-cyano containing pyrethroids (bifenthrin, S-bioalle
Autor:
Kevin Bailey, David E. Ray, Vasanthy Vigneswara, Anna U. Newlaczyl, Benita L. McVicker, Dean J. Tuma, Wayne G. Carter, Kusum K. Kharbanda
Publikováno v:
Biochemical and Biophysical Research Communications
We employed a proteomic profiling strategy to examine the effects of ethanol and betaine diet supplementation on major liver protein level changes. Male Wistar rats were fed control, ethanol or betaine supplemented diets for 4weeks. Livers were remov
Publikováno v:
Journal of Neurochemistry. 79:400-406
In humans and other vertebrates, reaction of organophosphates with a neuronal membrane protein, neuropathy target esterase (NTE), initiates events which culminate in axonal degeneration. The initiation process appears to involve modification of a pro
Autor:
Andriani Athanasiou, David A. Kendall, Robert Layfield, Paul A. Smith, Andrew D. Westwell, David E. Ray, Amy E. Turner, De-an Guo, Kenneth A. Muir, Timothy E. Bates, Nethia M. Kumaran, Stephen P.H. Alexander, Dimitra Bagiokou, Sara Vakilpour, Dileep N. Lobo, Susan A. Watson, Artitaya Lophatanon
Publikováno v:
Biochemical and Biophysical Research Communications. 354:50-55
Time-lapse photomicroscopy of human H460 lung cancer cells demonstrated of the transient receptor potential V1 (TRPV1) channel agonists, (E)-capsaicin and resiniferatoxin, and the TRPV1 antagonists, capsazepine, and SB366791, were able to bring about
Autor:
Colin L. Willis, David E. Ray
Publikováno v:
NeuroToxicology. 28:161-167
Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases and may result from excessive free radical production due to increased local metabolism. Non-competitive N-methyl-D-aspartate (NMDA) antagonists (MK-801 an
Publikováno v:
Toxicology and Applied Pharmacology. 216:354-362
The default assumption that different pyrethroid insecticides, sharing a common mode of action, will show additivity of toxicity has not always been supported by in vitro measures, some of which have indicated antagonism. Our intention was to see whe