Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David E. Mortenson"'
Autor:
Maria Livia Sassano, Alexander R. van Vliet, Hery Urra, Alfredo Sagredo, David E. Mortenson, Geert Bultynck, Patrizia Agostinis, Nibaldo C. Inestrosa, Angie K. Torres, Amado Carreras-Sureda, Claudio Hetz, R. Luke Wiseman, Sylvère Durand, Galdo Bustos, Christian Gonzalez-Billault, Cheril Tapia-Rojas, Younis Hazari, Felipe A. Court, Fabián Jaña, Eva Ramos-Fernández, Rubén Vicente, Martijn Kerkhofs, Guido Kroemer, Randal J. Kaufman, J César Cárdenas, Matías González-Quiroz, Philippe Pihán
Publikováno v:
Nat Cell Biol
Nature Cell Biology
Nature Cell Biology
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected function of the endoplasmic reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b86404bc67f8fe50110855ff94df40
https://europepmc.org/articles/PMC7246037/
https://europepmc.org/articles/PMC7246037/
Autor:
Rachel C. Botham, K. Barry Sharpless, David E. Mortenson, Christophe Morisseau, Hua Wang, Bruce D. Hammock, Jeffery W. Kelly, Suhua Li, Gencheng Li, Luke T Nelson, Gabriel J. Brighty
Publikováno v:
Nature chemistry. 12(10)
Drug candidates that form covalent linkages with their target proteins have been underexplored compared with the conventional counterparts that modulate biological function by reversibly binding to proteins, in part due to concerns about off-target r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd66c8cd18eb8b13ce9456a57915a55
https://pubmed.ncbi.nlm.nih.gov/32978603
https://pubmed.ncbi.nlm.nih.gov/32978603
Autor:
Benjamin R. Travis, Dale F. Kreitler, Zhihui Yao, Lijun Huang, Jay D. Steinkruger, Katrina T. Forest, Ritesh Mittal, David E. Mortenson, Samuel H. Gellman
The structural principles that govern interactions between l- and d-peptides are not well understood. Among natural proteins, coiled-coil assemblies formed between or among α-helices are the most regular feature of tertiary and quaternary structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902034d4d1b2c45090c76bc3df823acf
https://europepmc.org/articles/PMC6500429/
https://europepmc.org/articles/PMC6500429/
Autor:
B. Lachele Foley, David A. Case, Jeffery W. Kelly, Che-Hsiung Hsu, Evan T. Powers, Sangho Park, Chi-Huey Wong, David E. Mortenson, H. Jane Dyson, Xiaocong Wang, Robert J. Woods
Publikováno v:
Journal of the American Chemical Society. 138:7636-7648
Interactions between proteins and carbohydrates are ubiquitous in biology. Therefore, understanding the factors that determine their affinity and selectivity are correspondingly important. Herein, we have determined the relative strengths of intramol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d868b294119734259b7ed8b5ae34ac5
https://doi.org/10.1021/jacs.6b02879
https://doi.org/10.1021/jacs.6b02879
Autor:
Katrina T. Forest, Kenneth A. Satyshur, Nicole C. Thomas, David E. Mortenson, Samuel H. Gellman, Bernard Weisblum, Zvi Hayouka
Publikováno v:
Journal of the American Chemical Society. 137:11884-11887
Quasiracemic crystallography has been used to explore the significance of homochiral and heterochiral associations in a set of host-defense peptide derivatives. The previously reported racemic crystal structure of a magainin 2 derivative displayed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eea2fb6f2859e7019e0eac493720f9f
https://doi.org/10.1021/jacs.5b07206
https://doi.org/10.1021/jacs.5b07206
Autor:
Ian A. Wilson, Gabriel J. Brighty, K. Barry Sharpless, Stefano Forli, Hua Wang, Suhua Li, Wentao Chen, Jeffery W. Kelly, Benjamin F. Cravatt, Lars Plate, Evan T. Powers, David E. Mortenson, Grant A. L. Bare
Publikováno v:
Journal of the American Chemical Society. 140(1)
Drug candidates are generally discovered using biochemical screens employing an isolated target protein or by utilizing cell-based phenotypic assays. Both noncovalent and covalent hits emerge from such endeavors. Herein, we exemplify an "Inverse Drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda856191968c40956e8665044f9ce06
https://pubmed.ncbi.nlm.nih.gov/29265822
https://pubmed.ncbi.nlm.nih.gov/29265822
Autor:
Katrina T. Forest, Dale F. Kreitler, Nicole C. Thomas, Samuel H. Gellman, David E. Mortenson, Ilia A. Guzei
Publikováno v:
Chembiochem : a European journal of chemical biology. 19(6)
β-Amino acids have a backbone that is expanded by one carbon atom relative to α-amino acids, and β residues have been widely investigated as subunits in protein-like molecules that adopt discrete and predictable conformations. Two classes of β re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fe1d4cd57a3633545b6fdc25bdc178
https://pubmed.ncbi.nlm.nih.gov/29272560
https://pubmed.ncbi.nlm.nih.gov/29272560
Autor:
Ian A. Wilson, Stephen Connelly, Sungwook Choi, Evan T. Powers, David E. Mortenson, Jeffery W. Kelly, Steven M. Johnson
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochemical and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d691b399bea63c119736e53746d2804
https://pubmed.ncbi.nlm.nih.gov/28625364
https://pubmed.ncbi.nlm.nih.gov/28625364
Autor:
Amado Carreras-Sureda, David E. Mortenson, Guido Kroemer, Patrizia Agostinis, Randal J. Kaufman, Philippe Pihán, Galdo Bustos, Hery Urra, Alfredo Sagredo, Sylvère Durand, Matías González-Quiroz, R. Luke Wiseman, Maria Livia Sassano, Christian Gonzalez-Billault, J César Cárdenas, Cheril Tapia-Rojas, Younis Hazari, Angie K. Torres, Geert Bultynck, Alexander R. van Vliet, Claudio Hetz, Nibaldo C. Inestrosa, Martijn Kerkhofs, Rubén Vicente, Felipe A. Court, Fabián Jaña, Eva Ramos-Fernández
Publikováno v:
Nat Cell Biol
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected function of the endoplasmic reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e6efe6c849a70c6942a4c6a53235df
https://doi.org/10.1038/s41556-019-0355-9
https://doi.org/10.1038/s41556-019-0355-9
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 69:2506-2512
The human Pin1 WW domain is a small autonomously folding protein that has been useful as a model system for biophysical studies of β-sheet folding. This domain has resisted previous attempts at crystallization for X-ray diffraction studies, perhaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e57ba229e23178ee708348ef55bf866
https://doi.org/10.1107/s090744491302444x
https://doi.org/10.1107/s090744491302444x