Zobrazeno 1 - 10
of 159
pro vyhledávání: '"David E. Martin"'
Publikováno v:
Viruses, Vol 16, Iss 7, p 1087 (2024)
Human metapneumovirus (HMPV) is an important cause of acute respiratory tract infection and causes significant morbidity and mortality. There is no specific antiviral drug to treat HMPV or vaccine to prevent HMPV. This study determined if probenecid,
Externí odkaz:
https://doaj.org/article/3aa158ab962b40498e9c110209287ab8
Autor:
Jackelyn Murray, David E. Martin, Sarah Hosking, Nichole Orr-Burks, Robert J. Hogan, Ralph A. Tripp
Publikováno v:
Viruses, Vol 16, Iss 1, p 152 (2024)
Avian influenza (AI) viruses cause infection in birds and humans. Several H5N1 and H7N9 variants are highly pathogenic avian influenza (HPAI) viruses. H5N1 is a highly infectious bird virus infecting primarily poultry, but unlike other AIs, H5N1 also
Externí odkaz:
https://doaj.org/article/c244c4c82587489cad1b76cb4dbc4d7e
Publikováno v:
Viruses, Vol 15, Iss 12, p 2366 (2023)
Influenza can cause respiratory infections, leading to significant morbidity and mortality in humans. While current influenza vaccines offer varying levels of protection, there remains a pressing need for effective antiviral drugs to supplement vacci
Externí odkaz:
https://doaj.org/article/a8f0fb5536f24a7c8c246d5097690d88
Autor:
Ralph A. Tripp, David E. Martin
Publikováno v:
Viruses, Vol 15, Iss 11, p 2254 (2023)
In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements. These assays are designed to evaluate the effectiveness of new and know
Externí odkaz:
https://doaj.org/article/aa64655e37624cf690f76cffb35f0479
Autor:
Jackelyn Murray, Robert J. Hogan, David E. Martin, Kathy Blahunka, Fred D. Sancilio, Rajiv Balyan, Mark Lovern, Richard Still, Ralph A. Tripp
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show pro
Externí odkaz:
https://doaj.org/article/d191ef95cc404745a8ce8416434d12ad
Autor:
David E. Martin, Neelam Pandey, Purvi Chavda, Gurpreet Singh, Rakesh Sutariya, Frederic Sancilio, Ralph A. Tripp
Publikováno v:
Viruses, Vol 15, Iss 7, p 1508 (2023)
Probenecid is an orally bioavailable, uricosuric agent that was first approved in 1951 for the treatment of gout, but was later found to have potent, broad-spectrum antiviral activity against several respiratory viruses including SARS-CoV-2. We condu
Externí odkaz:
https://doaj.org/article/49bcba3c8a2d4627be3330b12557bf3a
Autor:
Jackelyn Murray, Harrison C. Bergeron, Les P. Jones, Zachary Beau Reener, David E. Martin, Fred D. Sancilio, Ralph A. Tripp
Publikováno v:
Viruses, Vol 14, Iss 5, p 912 (2022)
RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are dependent on host genes for replication. We investigated if probenecid, an FDA-approved and safe urate-lowering drug that inhibits organic anion transporters (OAT
Externí odkaz:
https://doaj.org/article/1c44e9709c554a5ea640bb450efa08af
Autor:
Ralph A. Tripp, David E. Martin
Publikováno v:
Viruses, Vol 14, Iss 3, p 612 (2022)
Viral replication and transmissibility are the principal causes of endemic and pandemic disease threats. There remains a need for broad-spectrum antiviral agents. The most common respiratory viruses are endemic agents such as coronaviruses, respirato
Externí odkaz:
https://doaj.org/article/64f66a23f1574bc092d90c19d1785b97
Autor:
Tripp, David E. Martin, Neelam Pandey, Purvi Chavda, Gurpreet Singh, Rakesh Sutariya, Frederic Sancilio, Ralph A.
Publikováno v:
Viruses; Volume 15; Issue 7; Pages: 1508
Probenecid is an orally bioavailable, uricosuric agent that was first approved in 1951 for the treatment of gout, but was later found to have potent, broad-spectrum antiviral activity against several respiratory viruses including SARS-CoV-2. We condu