Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David E. Lenz"'
Autor:
Mohosin Sarkar, Christina Keventzidis Harsch, George T. Matic, Kathryn Hoffman, Joseph R. Norris, Tamara C. Otto, David E. Lenz, Douglas M. Cerasoli, Thomas J. Magliery
Publikováno v:
Journal of Lipids, Vol 2012 (2012)
Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, and it is a possible lead molecule
Externí odkaz:
https://doaj.org/article/35be391fb4584692816b53e50b774e5a
Autor:
Tamara C. Otto, Sean M. Hodgins, Douglas M. Cerasoli, Benedict R. Capacio, Robyn B. Lee-Stubbs, David E. Lenz, C. Linn Cadieux, Stuart J. Armstrong, Tony E. Reeves, Shane A. Kasten
Publikováno v:
Biochemical pharmacology. 171
Human butyrylcholinesterase (E.C. 3.1.1.8) purified from blood plasma has previously been shown to provide protection against up to five and a half times the median lethal dose of an organophosphorus nerve agent in several animal models. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c33ce0a3135f70c40f82a482a17a538
https://pubmed.ncbi.nlm.nih.gov/31628910
https://pubmed.ncbi.nlm.nih.gov/31628910
Publikováno v:
Chemical Warfare Agents ISBN: 9781498769235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555553603e53a674e2fdec87722d123d
https://doi.org/10.1201/9781498769235-18
https://doi.org/10.1201/9781498769235-18
Autor:
Tamara C. Otto, David C. Davis, Zhi Liu, J. Richard Smith, Robert Balcerzak, Marita Tolosa, Elena S. Kovaleva, Douglas M. Cerasoli, Shane A. Kasten, David E. Lenz, George W. Buchman
Publikováno v:
Chemico-Biological Interactions. 187:388-392
Human serum paraoxonase-1 (HuPON1) is difficult to either purify from plasma or functionally express in high yield from recombinant sources. Here, we describe the characterization of functional HuPON1 expressed and purified from Trichoplusia ni (T. n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe6a4f6efa8e45fa585d24ede461122
https://doi.org/10.1016/j.cbi.2010.02.022
https://doi.org/10.1016/j.cbi.2010.02.022
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 75:486-498
Human paraoxonase (HuPON1) is a serum enzyme that exhibits a broad spectrum of hydrolytic activities including the hydrolysis of various organophosphates esters, and recently identified lactone substrates. Despite intensive site-directed mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2bcb1b0780fa75a0a1f8f6fcfd9e9a
https://doi.org/10.1002/prot.22264
https://doi.org/10.1002/prot.22264
Autor:
Douglas M. Cerasoli, David E. Lenz, C. Linn Cadieux, Taylor Phillips, John G. Bruno, Maria P. Carrillo
Publikováno v:
Journal of Molecular Recognition. 22:197-204
Twelve rounds of systematic evolution of ligands by exponential enrichment (SELEX) were conducted against a magnetic bead conjugate of the para-aminophenylpinacolylmethylphosphonate (PAPMP) derivative of the organophosphorus (OP) nerve agent soman (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d151b8393429d8c9152da190625765
https://doi.org/10.1002/jmr.932
https://doi.org/10.1002/jmr.932
Autor:
David T Yeung, David E. Lenz, Lucille A. Lumley, Richard E. Sweeney, J. Richard Smith, Douglas M. Cerasoli
Publikováno v:
Toxicology. 233:31-39
Currently fielded treatments for nerve agent intoxication promote survival, but do not afford complete protection against either nerve agent-induced motor and cognitive deficits or neuronal pathology. The use of human plasma-derived butyrylcholineste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672b3297cadba29bceb5f0170c973028
https://doi.org/10.1016/j.tox.2006.11.066
https://doi.org/10.1016/j.tox.2006.11.066
Publikováno v:
FEBS Journal. 274:1183-1191
Human serum paraoxonase 1 (HuPON1; EC 3.1.8.1) is a calcium-dependent six-fold β-propeller enzyme that has been shown to hydrolyze an array of substrates, including organophosphorus (OP) chemical warfare nerve agents. Although recent efforts utilizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eb45055ade8e2a2fb6d2113bb812277
https://doi.org/10.1111/j.1742-4658.2006.05650.x
https://doi.org/10.1111/j.1742-4658.2006.05650.x
Autor:
Lydia Aldaz-Carroll, James H. Campbell, Jae Sly, Huan Lou, Douglas M. Cerasoli, Al Toledo, Kim Love, Roselyn J. Eisenberg, Richard W. Welch, J C Whitbeck, Helen Latzgo, David E. Lenz, Dave Davis, Pinal Patel, Gary H. Cohen, Gary Haupt
Publikováno v:
BioProcessing Journal. 5:63-70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a6c687a39972c0fa73d09687ba2020e
https://doi.org/10.12665/j52.welch
https://doi.org/10.12665/j52.welch
Autor:
Ashima Saxena, Chunyuan Luo, Bhupendra P. Doctor, David E. Lenz, Wei Sun, Irwin Koplovitz, Todd M. Myers
Publikováno v:
Journal of Molecular Neuroscience. 30:145-148
Current antidotal regimens for organophosphorus compound (OP) poisoning consist of a combination of pretreatment with a spontaneously reactivating AChE inhibitor such as pyridostigmine bromide, and postexposure therapy with anticholinergic drugs such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6426856a534740816da77085afdd21ab
https://doi.org/10.1385/jmn:30:1:145
https://doi.org/10.1385/jmn:30:1:145