Zobrazeno 1 - 10
of 183
pro vyhledávání: '"David E. Lee"'
Autor:
Akshay Bareja, David E. Lee, Tricia Ho, Greg Waitt, Lauren H. McKay, Sarah A. Hannou, Melissa C. Orenduff, Kristen M. McGreevy, Alexandra Binder, Calen P. Ryan, Erik J. Soderblom, Daniel W. Belsky, Luigi Ferrucci, Jayanta Kumar Das, Nirad Banskota, Virginia B. Kraus, Janet L. Huebner, William E. Kraus, Kim M. Huffman, Gurpreet S. Baht, Steve Horvath, Robert J. Parmer, Lindsey A. Miles, James P. White
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113881- (2024)
Summary: An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilize
Externí odkaz:
https://doaj.org/article/427aacba1e9c45278727a51ef1f744a6
Autor:
David E. Lee, Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, James P. White
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Lee et al. demonstrate the protein Meteorin-like can rejuvenate the body’s immune system to enhance muscle regeneration in old age – in part by inducing the death of pro-fibrotic mesenchymal progenitor cells within the muscle.
Externí odkaz:
https://doaj.org/article/8fcfebcc8c834ce3ab90df115f69407e
Autor:
Tyrone A. Washington, Wesley S. Haynie, Eleanor R. Schrems, Richard A. Perry, Jr., Lemuel A. Brown, Breanna M. Williams, Megan E. Rosa-Caldwell, David E. Lee, Jacob L. Brown
Publikováno v:
Sports Medicine and Health Science, Vol 4, Iss 3, Pp 198-208 (2022)
The ability of skeletal muscle to regenerate from injury is crucial for locomotion, metabolic health, and quality of life. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1A) is a transcriptional coactivator required for mitochondri
Externí odkaz:
https://doaj.org/article/dbef22a1cf4f4ed99f07d4477019e67f
Autor:
Megan E. Rosa‐Caldwell, Seongkyun Lim, Wesley S. Haynie, Jacob L. Brown, David E. Lee, Kirsten R. Dunlap, Lisa T. Jansen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 2056-2068 (2021)
Abstract Background Disuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse‐induced muscle atrophy. Little data exist on early mechanisms cont
Externí odkaz:
https://doaj.org/article/c078e7da58e44ab58e7d90e1f6efbd14
Autor:
Megan E. Rosa‐Caldwell, Seongkyun Lim, Wesley A. Haynie, Jacob L. Brown, John William Deaver, Francielly Morena Da Silva, Lisa T. Jansen, David E. Lee, Michael P. Wiggs, Tyrone A. Washington, Nicholas P. Greene
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 717-730 (2021)
Abstract Background Muscle atrophy is a common pathology associated with disuse, such as prolonged bed rest or spaceflight, and is associated with detrimental health outcomes. There is emerging evidence that disuse atrophy may differentially affect m
Externí odkaz:
https://doaj.org/article/700d34c0af274608a96bc412768a4479
Autor:
David E. Lee, Jacob L. Brown, Megan E. Rosa‐Caldwell, Richard A. Perry, Lemuel A. Brown, Wesley S. Haynie, Tyrone A. Washington, Michael P. Wiggs, Narasimhan Rajaram, Nicholas P. Greene
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 1, Pp 3-15 (2021)
Abstract Background Cachexia presents in 80% of advanced cancer patients; however, cardiac atrophy in cachectic patients receives little attention. This cardiomyopathy contributes to increased occurrence of adverse cardiac events compared with age‐
Externí odkaz:
https://doaj.org/article/94dc1db4c6c24897bcaf27c79362f0c1
Autor:
Jacob L. Brown, David E. Lee, Megan E. Rosa‐Caldwell, Lemuel A. Brown, Richard A. Perry, Wesley S. Haynie, Kendra Huseman, Kavithalakshmi Sataranatarajan, Holly Van Remmen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 5, Pp 987-1002 (2018)
Abstract Background Cancer cachexia occurs in approximately 80% of cancer patients and is a key contributor to cancer‐related death. The mechanisms controlling development of tumour‐induced muscle wasting are not fully elucidated. Specifically, t
Externí odkaz:
https://doaj.org/article/34e2fe6cc5db40f29d728458fc6773bb
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a
Externí odkaz:
https://doaj.org/article/12da4e8aab0a4b238d07084513342ee6
Autor:
Richard A. Perry, Jr., Lemuel A. Brown, David E. Lee, Jacob L. Brown, Jamie I. Baum, Nicholas P. Greene, Tyrone A. Washington
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 1426-1432 (2016)
The data described herein is related to the article “Differential Effects of Leucine Supplementation in Young and Aged Mice at the Onset of Skeletal Muscle Regeneration” [1]. Aging is associated with a decreased ability of skeletal muscle to rege
Externí odkaz:
https://doaj.org/article/1d72dd9500f2442da1f0be22e22d3e81
Autor:
Megan E. Rosa-Caldwell, Conner A. Benson, David E. Lee, Jacob L. Brown, Tyrone A. Washington, Nicholas P. Greene, Michael P. Wiggs
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7841 (2020)
It is established that cancer cachexia causes limb muscle atrophy and is strongly associated with morbidity and mortality; less is known about how the development of cachexia impacts the diaphragm. The purpose of this study was to investigate cellula
Externí odkaz:
https://doaj.org/article/178242f455744cb9a6404adb26d5eff2